Academic Organization


http://www.dent.niigata-u.ac.jp/perio/perio.html




- The genetic background to periodontal disease (various genetic polymorphisms)
- Immunopathological approach for onset and progression of periodontal diseases
- Regenaration and reconstruction for periodontal tissues by tissue engineering
- Development of Immuno-therapy for periodontal disese by human monoclonal antibodies
- Application of matrixmetalloproteinase-inhibitors for periodontal therapy
- Relationship between periodontal disease and cigaret smoking: clinical and molecular biological study
- Systemic diseases and Periodontal desease




Hiromasa, YoshieProfessorDepartment of Periodontology, faculty of dentistry
Kazuhisa, Yamazaki ProfessorDepartment of Periodontology, faculty of dentistry
Kazuhiro, Okuda Associate ProfessorDepartment of Periodontology, faculty of dentistry
Tetsuo, Kobayashi ProfessorDepartment of Periodontology, faculty of dentistry
Noriko, Sugita Assistant ProfDepartment of Periodontology, faculty of dentistry
Takako, Nakajima Associate ProfessorDepartment of Periodontology, faculty of dentistry
Takehiko, Kubota Associate ProfessorDepartment of Periodontology, faculty of dentistry
Koichi, Tabeta Assistant ProfDepartment of Periodontology, faculty of dentistry
Toshiya, Morozumi Assistant ProfDepartment of Periodontology, faculty of dentistry
Harue, Ito Assistant ProfDepartment of Periodontology, faculty of dentistry
Yasutaka, KomatsuAssistant Prof
Tomoki, MaekawaAssistant Prof
Naoki,TakahashiAssistant Prof
Yukari, NonakaClinical Instructor
Sayuri, MiyauchiPostdoctoral fellow
Makoto, HorimizuClinical Instructor
Haruna, Miyazawa Clinical Instructor
Mayuka, Nakajima
Atsushi, ShimadaGraduate Student
Yumi, MatsudaGraduate Student
Ayumi, KurokiGraduate Student
Keisuke, SatoGraduate Student
Arata, NezuGraduate Student
Takahiro, HokariGraduate Student
Che YulanGraduate Student
Mai, YokojiGraduate Student
Miki, YamadaGraduate Student
Yasuko, NemotoGraduate Student
Yasuhito, OfujiAdjunct Instructor
Hideaki,TaiAdjunct Instructor
Takao, SodeyamaAdjunct Instructor
Masashi, Murata Adjunct Instructor
Koji, YamamotoAdjunct Instructor
Yu, NakajimaAdjunct Instructor
Mana, KamiyaAdjunct Instructor
Mito, KobayashiAdjunct Instructor
Tomomi, MeguroSecretary





Kobayashi T, Yoshie H / 1. Genetic predisposition to periodontitis. / Yoshie Hiromasa / AT THE FOREFRONT. Illustrated Topics in Dental Research and Clinical Practice / / Quintessence / Chicago, USA / 2012 / 3 / 6 /

Tabeta K, Yamazaki K / Molecular Techniques and Applications Analysis of Immune Responses to Purified Recombinant Antigens of Periodontal Pathogens. / Seymour GJ, Cullinan MP, Heng NCK / Oral Biology / / Springer / Oxford, UK / 2010 / 354 / 357 /

Yamazaki K, Ito H / Molecular Techniques and Applications Single-Strand Conformation Polymorphism Analysis for the Diagnosis of T-Cell Clonality in Periodontal Disease. / Seymour GJ, Cullinan MP, Heng NCK / Oral Biology / / Springer / Oxford, UK / 2010 / 359 / 372 /

Seymour GJ, Gemmell E, Yamazaki K / T cell responses in periodontitis. / Henderson B, Curtis M, Seymour RA, Donos N. / In: Periodontal Medicine and Systems Biology. / / Wiley-Blackwell / Oxford, UK / 2009 /

Kobayashi T., Yamamoto K., Sugita N., W-L van der Pol, N.A.C. Westerdaal, Yasuda K., Kaneko S., J. G. J. van de Winkel, Yoshie H. / The Fcg Receptor Genotype as a Marker for Early-Onset Periodontitis Risk and Adult Periodontitis Severity. / / / / / Italy / 2001 / 16 / 19 /

Kobayashi T, van der Pol W-L, Hara K, van de Winkel JGJ / IgG Fc receptor polymorphisms: genetic risk factors for periodontal disease / B.Guggenheim & S.Shapiro / ORAL BIOLOGY AT THE TURN OF THE CENTURY / / / / 1998 / 151 / 158 /



Morozumi T, Nakagawa T, Nomura Y, Sugaya T, Kawanami M, Suzuki F, Takahashi K, Abe Y, Sato S, Makino-Oi A, Saito A, Takano S, Minabe M, Nakayama Y, Ogata Y, Kobayashi H, Izumi Y, Sugano N, Ito K, Sekino S, Numabe Y, Fukaya C, Yoshinari N, Fukuda M, Noguchi T, Kono T, Umeda M, Fujise O, Nishimura F, Yoshimura A, Hara Y, Nakamura T, Noguchi K, Kakuta E, Hanada N, Takashiba S, Yoshie H / Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-month prospective multicenter cohort study / J Periodont Res / / / / in press / Online Journal

Wang Y, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yosie H / PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women. / Gerodontology / / / / in press / Online Journal

Kojima A, Kobayashi T, Ito S, Murasawa A, Nakazono K, Yoshie H / Tumor necrosis factor-alpha gene promoter methylation in Japanese adults with chronic periodontitis and rheumatoid arthritis / J Periodontal Res / 51(3) / 350 / 358 / 2016 / Online Journal

Kitamura M, Akamatsu M, Kawanami M, Furuichi Y, Fujii T, Mori M, Kunimatsu K, Shimauchi H, Ogata Y, Yamamoto M, Nakagawa T, Sato S, Ito K, Ogasawara T, Izumi Y, Gomi K, Yamazaki K, Yoshie H, Fukuda M, Noguchi T, Takashiba S, Kurihara H, Nagata T, Hamachi T, Maeda K, Yokota M, Sakagami R, Hara Y, Noguchi K, Furuuchi T, Sasano T, Imai E, Ohmae M, Koizumi H, Watanuki M, Murakami S / Randomized placebo-controlled and controlled non-inferiority phase III trials comparing trafermin, a recombinant human fibroblast growth factor 2, and enamel matrix derivative in periodontal regeneration in intrabony defects / J Bone Miner Res / 31(4) / 806 / 814 / 2016 / Online Journal

Nakajima T, Okui T, Ito H, Nakajima M, Honda T, Shimada Y, Tabeta K, Akazawa K, Yamazaki K / Microbiological and clinical effects ofssitafloxacinand azithromycin in periodontitis patients receiving supportive periodontaltherapy / Antimicrob Agents Chemother / 60(3) / 1779 / 1787 / 2016 / Online Journal

Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y / Anti-biofilm and bactericidal effects of Magnolia bark-derived magnolol and honokiol on Streptococcus mutans / Microbiol Immunol / 60(1) / 10 / 16 / 2016 / Online Journal

Shimada A, Kobayashi T, Ito S, Okada M, Murasawa A, Nakazono K, Yoshie H / Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis / J Periodont Res / 51(2) / 103 / 111 / 2016 / Online Journal

Shimizu T, Kubota T, Iwasaki M, Morozumi T, Yoshie H / Changes in biomarkers after initial periodontal treatment in gingival crevicular fluid from patients with chronic periodontitis presenting with drug-induced gingival overgrowth / Open Journal of Stomatology / 6 / 64 / 72 / 2016 / Online Journal

Abe T, AlSarhan M, Benakanakere MR, Maekawa T, Kinane DF, Cancro MP, Korostoff JM, Hajishengallis G / The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis / J Immunol / 195(4) / 1427 / 1435 / 2015 / Online Journal

Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD / Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches / Adv Exp Med Biol / 865 / 57 / 74 / 2015 / Online Journal

Hanai Y, Sugita N, Wang Y, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H / Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women / Arch Oral Biol / 60(4) / 533 / 539 / 2015 / Online Journal

Imamura K, Takayama S, Saito A, Inoue E, Nakayama Y, Ogata Y, Shirakawa S, Nagano T, Gomi K, Morozumi T, Akiishi K, Watanabe K, Yoshie H / Evaluation of a novel immunochromatographic device for rapid and accurate clinical detection of Porphyromonas gingivalis in subgingival plaque / J Microbiol Methods / 117 / 4 / 10 / 2015 / Online Journal

Kawase T, Kamiya M, Kobayashi M, Tanaka T, Okuda K, Wolff LF, Yoshie H / The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation / J Biomed Mater Res B Appl Biomater / 103(3) / 825 / 831 / 2015 / Online Journal

Kawase T, Tanaka T, Okuda K, Tuchimochi M, Oda M, Hara T / Quantitative Single-Cell Motility Analysis of Platelet-Rich Plasma-Treated Endothelial Cells In Vitro / Cytoskeleton / 72 / 246 / 255 / 2015 / Online Journal

Kobayashi M, Kawase T, Okuda K, Wolff LF, YoshieH / In vitro immunological and biological evaluations of the angiogenic potential of platelet-rich fibrin preparations: a standardized comparison with PRP preparations / International Journal of Implant Dentistry / 1 / 31 / / 2015 / Online Journal

Kobayashi T, Ito S, Kobayashi D, Kojima A, Shimada A, Narita I, Murasawa A, Nakazono K, Yoshie H / Interleukin-6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors / Clinical and Experimental Dental Research / 1(2) / 63 / 73 / 2015 / Online Journal

Kubo M, Nishikawa Y, Harada K, Oda M, Huang JM, Domon H, Terao Y, Fukuyama Y / Tetranorsesquiterpenoids and santalane-type sesquiterpenoids from Illicium lanceolatum and their antimicrobial activity against the oral pathogen Porphyromonas gingivalis / J Nat Prod / 78 / 1466 / 1469 / 2015 / Online Journal

Kurosawa M, Oda M, Domon H, Saitoh I, Hayasaki H, Terao Y / Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells / Microb Infect / 18(2) / 118 / 127 / 2015 / Online Journal

Maekawa T, Hosur K, Abe T, Kantarci A, Van Dyke TE, Chavakis T, Hajishengallis G / Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway / Nature Commun / 6 / 8272 / / 2015 / Online Journal

Minagawa T, Okui T, Takahashi N, Nakajima T, Tabeta T, Murakami S, Yamazaki K / Resveratrol suppresses the inflammatory responses of human gingival epithelial cells in a SIRT1-independent manner / J Periodont Res / 50(5) / 586 / 593 / 2015 / Online Journal

Nakajima M, Arimatsu K, Kato T, Matsuda Y, Minagawa T, Takahashi N, Ohno H, Yamazaki K / Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver / PLoS One / 10(7) / e0134234 / / 2015 / Online Journal

Okuda K, Nakajima Y, Kawase T, Kobayashi M, Kamiya M, Horimizu M, Wolff LF, Yoshie H / Platelet-rich fibrin membrane combined with beta-tricalcium phosphate for treatment of infrabony defects in chronic periodontitis: a case series / J J Dent Res / 2(3) / 22 / / 2015 / Online Journal

Shin J*, Maekawa T*, Abe T, Hajishengallis E, Hosur K, Chavakis T, Hajishengallis G / The homeostatic factor Del-1 restrains osteoclastogenesis and inhibits bone loss in non-human primates / Science Transl Med / 7(307) / 307ra155 / / 2015 / Online Journal

Yamada H, Nakajima T, Domon H, Honda T, Yamazaki K / ER stress response and bone loss in experimental periodontitis in mice / J Periodont Res / 50(4) / 500 / 508 / 2015 / Online Journal

Yoshihara A, Sugita N, Iwasaki M, Wang Y, Miyazaki H, Yoshie H, Nakamura K / The Interaction Between β-3 Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor Gamma Gene Polymorphism to Periodontal Disease in Community-Dwelling Elderly Japanese / J Periodontol / 86(8) / 955 / 963 / 2015 / Online Journal

Abe D, Kubota T, Morozumi T, Yoshie H / Upregulated genes in toll-like receptor (TLR) signaling pathway in periodontitis-affected gingival tissue. / Open Journal of Stomatology / 4(1) / 22 / 28 / 2014 / Online Journal

Aoki-Nonaka Y, Nakajima T, Miyauchi S, Miyazawa H, Yamada H, Domon H, Tabeta K, Yamazaki K / Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis. / J Periodontal Res / 49 / 69 / 76 / 2014 / Online Journal

Domon H, Tabeta K, Nakajima T, Yamazaki K / Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis. / J Periodontal Res / 49(4) / 536 / 543 / 2014 / Online Journal

Hagiwara M, Kurita-Ochiai T, Kobayashi R, Hashizume-Takizawa T, Yamazaki K, Yamamoto M / Sublingual Vaccine with GroEL Attenuates Atherosclerosis. / J Dent Res / 93 / 382 / 387 / 2014 / Online Journal

Kawase T, Uematsu K, Kamiya M, Nagata M, Okuda K, Burns DM, Nakata K, Yoshie H / Real-time quantitative PCR and flow-cytometric analyses of cell adhesion molecules expressed in human cell-multilayered periosteal sheets in vitro. / Cytotherapy / 16(5) / 653 / 661 / 2014 / Online Journal

Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H / Assessment of Interleukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Chronic Periodontitis. / J Periodontol / 85(1) / 57 / 67 / 2014 / Online Journal

Kobayashi T, Okada M, Ito S, Kobayashi D, Shinhara A, Muramatsu T, Kobayashi T, Narita I, Nakazono K, Murasawa A, Yoshie H / Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis / Open Journal of Stomatology / 4(2) / 49 / 55 / 2014 / Online Journal

Kubota T, Maruyama S, Abe D, Tomita T, Morozumi T, Nakasone N, Saku T, Yoshie H / Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues / Arch Oral Biol / 59(6) / 586 / 594 / 2014 / Online Journal

Maekawa T, Hajishengallis G / Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. / J Periodontal Res / 49(6) / 785 / 791 / 2014 / Online Journal

Maruyama S, Itagaki M, Ida-Yonemochi H, Kubota T, Yamazaki M, Abe T, Yoshie H, Cheng J, Saku T / Perlecan-enriched intercellular space of junctional epithelium provides primary infrastructure for leukocyte migration through squamous epithelial cells. / Histochem Cell Biol / 142(3) / 297 / 305 / 2014 / Online Journal

Nakajima M, Honda T, Miyauchi S, Yamazaki K / Th2 cytokines efficiently stimulate periostin production in gingival fibroblasts but periostin does not induce inflammatory response in gingival epithelial cells / Arch Oral Biol / 59 / 93 / 101 / 2014 / Online Journal

Okui T, Aoki-Nonaka Y, Nakajima T, Yamazaki K / The role of distinct T cell subsets in periodontitis - Studies from humans and rodent models / Curr Oral Health Rep / 1 / 114 / 123 / 2014 / Online Journal

Yokoyama T, Kobayashi T, Ito S, Yamagata A, Ishida K, Okada M, Oofusa K, Murasawa A, Yoshie H / Comparative Analysis of Serum Proteins in Relation to Rheumatoid Arthritis and Chronic Periodontitis. / J Periodontol / 85(1) / 103 / 112 / 2014 / Online Journal

Yoshihara A, Sugita N, Iwasaki M, Miyazaki H, Nakamura K / The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese. / J Clin Periodontol / 41(5) / 460 / 466 / 2014 / Online Journal

Horimizu M, Kawase T, Nakajima Y, Okuda K, Nagata M, LF. Wolff, Yoshie H / An improved freeze-dried PRP-coated biodegradable material suitable for connective tissue regenerative therapy. / Cryobiology / 66(3) / 223 / 232 / 2013 / Online Journal

Horimizu M, Kawase T, Tanaka T, Okuda K, Nagata M, Burns DM, Yoshie H / Biomechanical evaluation by AFM of cultured human cell-multilayered periosteal sheets. / Microns / 48 / 1 / 10 / 2013 / Online Journal

Huang H, Zhao P, Arimatsu K, Tabeta K, Yamazaki K, Krieg L, Fu E, Zhang T, Du X / A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice. / G3 (Bethesda) / 3(10) / 1687 / 1695 / 2013 / Online Journal

Kouya T, Tada S, Minbu H, Nakajima Y, Horimizu M, Kawase T, Lloyd DR, Tanaka T / Microporous membranes of PLLA/PCL blends for periosteal tissue scaffold. / Mater Lett / 95 / 103 / 106 / 2013 / Online Journal

Morozumi T, Kubota T, Abe D, Shimizu T, Nohno K, Yoshie H / Microbiological effect of essential oils in combination with subgingival ultrasonic instrumentation and mouthrinsing in chronic periodontitis patients. / Int J Dent / Epub / / / 2013 / Online Journal

Nakasone N, Ishida K, Yokoyama T, Okada M, Komatsu Y, Yoshie H / The change of HERS cell number and gene expression profile by occlusion during root development in rat molars / Open Journal of Stomatology / 3 / 8 / 14 / 2013 / Online Journal

Okuda K, Kawase T, Nagata M, Yamamiya K, Nakata K, Wolff LF, Yoshie H / Tissue engineered cultured periosteum sheet application to treat infrabony defects: case series and 5-year results. / Int J Periodontics Restorative Dent / 33 / 281 / 287 / 2013 / Online Journal

Shimada Y, Tabeta K, Sugita N, Yoshie H / Profiling biomarkers in gingival crevicular fluid using multiplex bead immunoassay. / Arch Oral Biol / 58(6) / 724 / 730 / 2013 / Online Journal

Tabeta K, Hoebe K, Janssen EM, Xia Y, Beutler B / Respond to No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice. / Nat Immunol / 14(11) / 1102 / 1103 / 2013 / Online Journal

Tomita T, Kubota T, Nakasone N, Morozumi T, Abe D, Maruyama S, Shimizu T, Horimizu M, Saku T, Yoshie H / Gene and protein localisation of Tumor Necrosis Factor (TNF) -α converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth. / Arch Oral Biol / 58(8) / 1014 / 1020 / 2013 / Online Journal

Uematsu K, Kawase T, Nagata M, Suzuki K, Okuda K, Yoshie H, Burns DM, Takagi R / Tissue culture of human alveolar periosteal sheets using a stem-cell culture medium (MesenPRO-RS™): In vitro expansion of CD146-positive cells and concomitant upregulation of osteogenic potential in vivo. / Stem Cell Res / 10 / 1 / 19 / 2013 / Online Journal

Wang Y, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H / Peroxisome proliferator-activated receptor (PPAR) g polymorphism, vitamin D, bone mineral density and periodontitis in postmenopausal women. / Oral Diseases / 19(5) / 501 / 506 / 2013 / Online Journal

Hagiwara M, Kurita-Ochiai T, Hashizume-Takizawa T, Suemitsu M, Kuyama K, Yamamoto H, Yamazaki K, Akimoto Y, Yamamoto M / Serum antibodies against Porphyromonas gingivalis GroEL are insufficient to induce P. gingivalis-accelerated atherosclerosis. / J Periodont Res / 11(4) / 291 / 299 / 2012 / Online Journal

Hirano E, Sugita N, Kikuchi A, Shimada Y, Sasahara J, Iwanaga R, Tanaka K, Yoshie H / The association of Aggregatibacter actinomycetemcomitans with preeclampsia in a subset of Japanese pregnant women. / J Clin Periodontol. / 39 / 229 / 238 / 2012 / Online Journal

Honda T, Takahashi N, Miyauchi S, Yamazaki K / Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines. / Biochem Biophys Res Commun / 4 / 918 / 925 / 2012 / Online Journal

Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, Abe A, Murasawa A, Yoshie H / Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis. / J Periodontol. / 83 / 917 / 925 / 2012 / Online Journal

Kamiya M, Kawase T, Kobayashi M, Sekine Yu, Okuda K, Nagata M, Fuse I, Nakata K, Wolff LF, Yoshie H / A short-term preservation of human cultured periosteal sheets, osteogenic grafting materials, using a commercial preservation solution containing epigallocatechin-3-gallate (Theliokeep) under chilled conditions. / Biopreserv Biobank / 10 / 245 / 252 / 2012 / Online Journal

Kobayashi M, Kawase T, Horimizu M, Okuda K, Wolff LF, Yoshie H / A proposed protocol for the standardized preparation of PRF membranes for clinical use. / Biologicals / 40 / 323 / 329 / 2012 / Online Journal

Komatsu Y, Morozumi T, Abe D, Okada M, Nakasone N, Okuda K, Yoshie H / Effects of Erbium-Doped: Yttrium Aluminum Garnet (Er: YAG) Laser on Bacteremia due to Scaling and Root Planing. / J Lasers Med Sci / 3 / 175 / 184 / 2012 / Online Journal

Kudo C, Naruishi K, Maeda H, Abiko Y, Hino T, Iwata M, Mitsuhashi C, Murakami S, Nagasawa T, Nagata T, Yoneda S, Nomura Y, NoguchiT, NumabeY, OgataY, Sato T, Shimauchi H, Yamazaki K, Yoshimura A, Takashiba S / Assessment of use of Plasma/Serum IgG Test to Screen for Periodontitis. / J Dent Res / 91(12) / 1190 / 1195 / 2012 / Online Journal

Miyashita H, Honda T, Maekawa T, Takahashi N, Aoki Y, Nakajima T, Tabeta K, Yamazaki K / Relationship between serum antibody titers to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis. / Archs oral Biol. / 57 / 820 / 829 / 2012 / Online Journal

Miyauchi S, Maekawa T, Aoki Y, Miyazawa H, Tabeta K, Nakajima T, Yamazaki K / Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR -ApoEshl mice. / J Periodont Res. / 1 / 402 / 408 / 2012 / Online Journal

Miyazawa H, Tabeta K, Miyauchi S, Aoki Y, Domon H, Honda T, Nakajima T, Yamazaki K / Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice. / Lipids in Health and Disease / 11 / 121 / / 2012 / Online Journal

Nagata M, Hoshina H, Li M, Arasawa M, Uematsu K, Ogawa S, Yamada K, Kawase T, Suzuki K, Ogose A, Amizuka N, Fuse I, Okuda K, Uoshima K, Nakata K, Yoshie H, Takagi R / A clinical study of the alveolar bone tissue engineering with cultured autogenous periosteal cells: coordinated activation of bone formation and resorption. / Bone / 50 / 1123 / 1129 / 2012 / Online Journal

Nakajima T, Okui T, Miyauchi S, Honda T, Shimada Y, Ito H, Akazawa K, Yamazaki K / The effects of systemic sitafloxacin on periodontal infection control in elderly patients. / Gerodontology. / 29 / e1024 / e1032 / 2012 / Online Journal

Nakajima Y, Kawase T, Kobayashi M, Okuda K, Wolff LF, Yoshie H / Bioactivity of freeze-dried platelet-rich plasma in an adsorbed form on a biodegradable polymer material. / Platelets. / 23 / 594 / 603 / 2012 / Online Journal

Nomura Y, Shimada Y, Hanada N, Numabe Y, Kamoi K, Sato T, Gomi K, Arai T, Inagaki K, Fukuda M, Noguchi T and Yoshie H / Salivary biomarkers for predicting the progression of chronic periodontitis. / Arch Oral Biol. / 57 / 413 / 420 / 2012 / Online Journal

Okui T, Aoki Y, Ito H, Honda T, Yamazaki K / The presence of IL-17+/FOXP3+ double-positive cells in periodontitis. / J Dent Res / 1 / 574 / 579 / 2012 / Online Journal

Shirai Y, Okuda K, Kubota T, Wolff LF, Yoshie H / The comparative effectiveness of granules or blocks of superporous hydroxyapatite for the treatment of intrabony periodontal defects. / Open Journal of Stomatology / 2 / 81 / 87 / 2012 / Online Journal

Sugita N, Iwanaga R, Kobayashi T, Yoshie H / Association of the FcγRIIB-nt645+25A/G polymorphism with the expression level of the FcγRIIb receptor, the antibody response to Porphyromonas gingivalis and the severity of periodontitis. / J Periodontal Res / 47 / 105 / 113 / 2012 / Online Journal

Sugita N, Kobayashi T, Kikuchi A, Shimada Y, Hirano E, Sasahara J, Tanaka K, Yoshie H / Immunoregulatory gene polymorphisms in Japanese women with preterm births and periodontitis. / J Reprod Immunol / 93 / 94 / 101 / 2012 / Online Journal

Wang Y, Sugita N, Kikuchi A, Iwanaga R, Hirano E, Shimada Y, Sasahara J, Tanaka K, Yoshie H / FcgRIIB-nt645+25A/G gene polymorphism and periodontitis in Japanese women with preeclampsia. / Int J Immunogenet / 39 / 492 / 500 / 2012 / Online Journal

Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H / Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. / J Periodont Res. / 46(3) / 345 / 353 / 2011 / Online Journal

Kawase T, Kogami H, Nagata M, Uematsu K, Okuda K, Burns DM, Yoshie H / Manual cryopreservation of human alveolar periosteal tissue segments: Effects of pre-culture on recovery rate. / Cryobiol . / 62 / 202 / 209 / 2011 / Online Journal

Kawase T, Tanaka T, Nishimoto T, Okuda K, Nagata M, Burns DM, Yoshie H / An osteogenic grafting complex composed of human periosteal sheet and a porous poly(L-lactic acid) membrane scaffold: Biocompatibility, biodegradability, and cell fate in vivo. / J Bioact Compat Polym, / 27(2) / 107 / 121 / 2011 / Online Journal

Kawase T, Tanaka T, Nishimoto T, Okuda K, Nagata M, Burns DM, Yoshie H / Improved adhesion of human cultured periosteal sheets to a porous poly (L-lactic acid) membrane scaffold without the aid of exogenous adhesion biomolecules. / J Biomed Mater Res A. / 98 / 100 / 113 / 2011 / Online Journal

Maekawa T, Tabeta K, Kajita-Okui K, Nakajima T, Yamazaki K / Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-6. / Arch Oral Biol. / 56 / 1312 / 1318 / 2011 / Online Journal

Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, Miyazawa H, Nakajima T, Yamazaki K / Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. / PLoS One. / 6 / 20240 / / 2011 / Online Journal

Miyazawa H, Honda T, Miyauchi S, Domon H, Okui T, Nakajima T, Tabeta K, Yamazaki K / Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration. / Clin Chim Acta. / 413 / 154 / 159 / 2011 / Online Journal

Nakasone N and Yoshie H / Occlusion regulates tooth- root elongation during root development in rat molars. / Eur J Oral Sci. / 119 / 418 / 426 / 2011 / Online Journal

Nakayama H, Kawase T, Okuda K, Wolff LF, Yoshie H / In-vivo near-infrared optical imaging of growing osteosarcoma cell lesions xenografted in mice: dual-channel quantitative evaluation of volume and mineralization. / Acta Radiol. / 52 / 978 / 988 / 2011 / Online Journal

Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H / Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults. / J Periodontol. / 82 / 1433 / 1441 / 2011 / Online Journal

Shibata Y, Okano S, Shiroza T, Tahara T, Nakazawa K, Kataoka S, Ishida I, Kobayashi T, Yoshie H, Abiko Y / Characterization of human-type monoclonal antibodies against reduced form of hemin binding protein 35 from Porphyromonas gingivalis. / J Periodont Res. / 46 / 673 / 681 / 2011 / Online Journal

Shimizu E, Kobayashi T, Wakabayashi H, Yamauchi K, Iwatsuki K, Yoshie H / Effects of orally administered lactoferrin and lactoperoxidase-containing tablets on clinical and bacteriological profiles in chronic periodontitis patients. / Int J Dent. / 405139 / / / 2011 / Online Journal

Tabeta K, Tanabe N, Yonezawa D, Miyashita H, Maekawa T, Takahashi N, Okui T, Nakajima T, Yamazaki K / Elevated antibody titers to Porphyromonas gingivalis as a possible predictor of ischemic vascular disease - results from the Tokamachi-Nakasato cohort study. / J Atheroscler Thromb. / 18 / 808 / 817 / 2011 / Online Journal

Takahashi N, Okui T, Tabeta K, Yamazaki K / Effect of interleukin-17 on the expression of chemokines in gingival epithelial cells. / Eur J Oral Sci. / 119 / 339 / 344 / 2011 / Online Journal

Yamazaki K, Tabeta K and Nakajima T / Periodontitis as a risk factor for atherosclerosis. / J Oral Biosci. / 53 / 221 / 232 / 2011 / Online Journal

Aoki Y, Tabeta K, Murakami Y, Yoshimura F, Yamazaki K / Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2. / Biochemical and Biophysical Research Communications. / 398 / 86 / 91 / 2010 / Online Journal

Hirano E, Sugita N, Kikuchi A, Shimada Y, Sasahara J, Iwanaga R, Tanaka K, Yoshie H / Peroxisome proliferator-activated receptor-gamma polymorphism and periodontitis in pregnant Japanese women. / J Periodontol. / 81 / 897 / 906 / 2010 / Online Journal

Iwanaga R, Sugita N, Hirano E, Sasahara J, Kikuchi A, Tanaka K, Yoshie H / FcgRIIB polymorphisms, periodontitis and preterm birth in Japanese pregnant women. / J Periodontal Res. / 46 / 292 / 302 / 2010 / Online Journal

Kawase T, Okuda K, Kogami H, Nakayama H, Nagata M, Sato T, Wolff LF, Yoshie H / Human periosteum-derived cells combined with superporous hydroxyapatite blocks used as an osteogenic bone substitute for periodontal regenerative therapy: Animal implantation study using nude mice. / J Periodontol. / 81 / 420 / 427 / 2010 / Online Journal

Kawase T, Yamanaka K, Suda Y, Kaneko T, Okuda K, Kogami H, Nakayama H, Nagata M, Wolff LF, Yoshie H / Collagen-coated poly(L-lactide-co-ε-caprolactone) film: A promising scaffold for cultured periosteal sheets. / J Periodontol. / 81 / 1653 / 1662 / 2010 / Online Journal

Kitamura M, Akamatsu M, Machigashira M, Hara Y, Sakagami R, Hirofuji T, Hamachi T, Maeda K, Yokota M, Kido J, Nagata T, Kurihara H, Takashiba S, Shibutani T, Fukuda M, Noguchi T, Yamazaki K, Yoshie H, Ioroi K, Arai T, Nakagawa T, Ito K, Oda S, Izumi Y, Ogata Y, Yamada S, Shimauchi H, Kunimatsu K, Kawanami M, Fujii T, Furuichi Y, Furuuchi T, Sasano T, Imai E, Omae M, Yamada S, Watanuki M, Murakami S / FGF-2 Stimulates Periodontal Regeneration: Results of a Multi-center Randomized Clinical Trial. / J Dent Res. / 90 / 35 / 40 / 2010 / Online Journal

Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H / Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults. / J Periodontol. / 81 / 650 / 657 / 2010 / Online Journal

Liang S, Hosur KB, Domon H, Hajishengallis G / Periodontal inflammation and bone loss in aged mice. / J Periodontal Res. / 45 / 574 / 578 / 2010 / Online Journal

Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G / The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. / J Immunol. / 186 / 869 / 877 / 2010 / Online Journal

Morozumi T, Kubota T, Abe D, Shimizu T, Komatsu Y, Yoshie H / Effects of irrigation with an antiseptic and oral administration of azithromycin on bacteremia caused by scaling and root planning. / J Periodontol. / 81 / 1555 / 1563 / 2010 / Online Journal

Nakajima T, Honda T, Domon H, Okui T, Kajita K, Ito H, Takahashi N, Maekawa T, Tabeta K, Yamazaki K / Periodontitis associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. / J. Periodont Res. / 45 / 116 / 122 / 2010 / Online Journal

Nakayama H, Kawase T, Kogami H, Okuda K, Inoue H, Oda T, Hayama K, Tsuchimochi M, Wolff LF / Evaluation by bone scintigraphy of osteogenic activity of commercial bioceramics (porous b-TCP and HAp particles) subcutaneously implanted in rats. / J Biomater Appl. / 24(8) / 751 / 768 / 2010 / Online Journal

Shimada Y, Ikezawa-Suzuki I, Tai H, Sugita N, Yoshie H / The effects of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. / J Periodontol. / 81 / 1118 / 1123 / 2010 / Online Journal

Shimizu T, Kubota T, Nakasone N, Abe D, Morozumi T, Yoshie H / Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients. / Arch Oral Biol. / 56 / 277 / 284 / 2010 / Online Journal

Takahashi N, Honda T, Domon H, Nakajima T, Tabeta K, Yamazaki K / IL-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. / J Periodontal Res. / 45(4) / 512 / 519 / 2010 / Online Journal

Wakabayashi H, Kondo I, Kobayashi T, Yamauchi K, Toida T, Iwatsuki K, Yoshie H / Periodontitis, periodontopathic bacteria and lactoferrin. / Biometals. / 23 / 419 / 424 / 2010 / Online Journal

Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou M, Triantafilou K, Lambris JD, Hajishengallis G / Microbial hijacking of complement-toll-like receptor crosstalk. / Sci Signal. / 3 / / / 2010 / Online Journal

Yokoyama T, Kobayashi T, Yamamoto K, Yamagata A, Oofusa K, Yoshie H / Proteomic profiling of human neutrophils in relation to immunoglobulin G Fc receptor IIIB polymorphism. / J Periodont Res. / 45 / 780 / 787 / 2010 / Online Journal

Domon H, Takahashi N, Honda T, Nakajima T, Tabeta K, Abiko Y, Yamazaki K / Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. / Clin Chim Acta. / 401 / 134 / 140 / 2009 / Online Journal

Fujita H, Kobayashi T, Tai H, Nagata M, Hoshina H, Nishizawa R, Takagi R, Yoshie H / Assessment of 14 functional gene polymorphisms in Japanese patients with oral lichen planus: a pilot case-control study. / Int J Oral Maxillofac Surg. / 38 / 978 / 983 / 2009 / Online Journal

Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K / Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. / J Exp Med. / 206 / 1339 / 1350 / 2009 / Online Journal

Hashimoto E, Nakakura-Ohshima K, Kenmotsu S, Suzuki H, Nakasone N, Saito C, Harada H, Ohshima H / The relationship between the cusp pattern and plural stem cell compartments in Guinea pig cheek teeth by chasing BrdU-labeling. / Arch Histol Cytol. / 71 / 317 / 332 / 2009 / Online Journal

Kawase T, Okuda K, Kogami H, Nakayama H, Nagata M, Nakata K, Yoshie H / Characterization of human cultured periosteal sheets expressing bone-forming potential: in vitro and in vivo animal studies. / J Tissue Eng Regen Med / 3 / 218 / 229 / 2009 / Online Journal

Kawase T, Okuda K, Kogami H, Nakayama H, Nagata M, Yoshie H / Osteogenic activity of human periosteal sheets cultured on salmon collagen-coated ePTFE meshes. / J Mater Sci Mater Med. / 21 / 731 / 739 / 2009 / Online Journal

Kiemer AK, Senaratne RH, Hoppst?dter J, Diesel B, Riley LW, Tabeta K, Bauer S, Beutler B, Zuraw BL. / Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. / J Innate Immun. / 1 / 29 / 45 / 2009 / Online Journal

Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, Sumida T, Yoshie H / Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. / J Periodontol. / 80 / 792 / 799 / 2009 / Online Journal

Kobayashi T, Nagata T, Murakami S, Takashiba S, Kurihara H, Izumi Y, Numabe Y, Watanabe H, Kataoka M, Nagai A, Hayashi J, Ohyama H, Okamatsu Y, Inagaki Y, Tai H, Yoshie H / Genetic risk factor for periodontitis in a Japanese population. / J Dent Res. / 88 / 1137 / 1141 / 2009 / Online Journal

Maekawa T, Takahashi N, Honda T, Yonezawa D, Miyashita H, Okui T, Tabeta K, Yamazaki K / Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the upregulation of early growth response-1 transcription in human coronary artery endothelial cells. / J Vasc Res. / 47 / 346 / 354 / 2009 / Online Journal

Morozumi T, Sharma A, De Nardin E / The functional effects of the -455G/A polymorphism on the IL-6-induced expression of the b-fibrinogen gene may be due to linkage disequilibrium with other functional polymorphisms. / Immunological Investigations. / 38 / 311 / 323 / 2009 / Online Journal

Nakagawa E, Itoh T, Yoshie H, Satokata I / Odontogenic potential of post-natal oral mucosal epithelium. / J Dent Res / 88 / 219 / 223 / 2009 / Online Journal

Nakajima T, Yamazaki K / Periodontal disease and risk of atherosclerotic coronary heart disease. / Odontology. / 97 / 84 / 91 / 2009 / Online Journal

Nakasone N, Kubota T, Hoshino C, Nohno K, Itagaki M, Shimizu T, Yoshie H / Differential gene and protein expression of tissue inhibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth. / Arch Oral Biol. / 54 / 634 / 641 / 2009 / Online Journal

Okuda K, Yamamiya K, Kawase T, Mizuno H, Ueda M, Yoshie H / Treatment of human infrabony periodontal defects by grafting human cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite granules: case series. / J Int Acad of Periodontol. / 11 / 206 / 213 / 2009 / Online Journal

Sasahara J, Kikuchi A, Takakuwa K, Sugita N, Abiko Y, Yoshie H, Tanaka K / Antibody responses to Porphyromonas gingivalis outer membrane protein in the first trimester. / Aust N Z J Obstet Gynaecol / 49 / 137 / 141 / 2009 / Online Journal

Seymour GJ, Ford PJ, Cullinan MP, Leishman S, West MJ, Yamazaki K / Infection or inflammation: the link between periodontal and cardiovascular diseases. / Future Cardiol. / 5 / 5 / 9 / 2009 / Online Journal

Shimada Y, Tai H, Tanaka A, Ikezawa-Suzuki I, Takagi K, Yoshida Y, Yoshie H. / Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo. / J Periodontol. / 80 / 317 / 323 / 2009 / Online Journal

Tabeta K, Shimada Y, Tai H, Ishihara Y, Noguchi T, Soga Y, Takashiba S, Suzuki G, Kobayashi T, Kobayashi T, Yamazaki K, Inoko H, Yoshie H / Assessment of chromosome 19 for genetic association in severe chronic periodontitis. / J Periodontol. / 80 / 663 / 671 / 2009 / Online Journal

Tsutsumi A, Kobayashi T, Ito S, Goto D, Matsumoto I, Yoshie H, Sumida T / Mannose binding lectin gene polymorphism and the severity of chronic periodontitis. / Jpn J Clin Immunol. / 32 / 48 / 52 / 2009 / Online Journal

Unno H, Suzuki H, Nakakura-Ohshima K, Jung HS, Ohshima H. / Pulpal regeneration following allogenic tooth transplantation into mouse maxilla. / Anat Rec. / 292 / 570 / 579 / 2009 / Online Journal

Wakabayashi H, Yamauchi K, Kobayashi T, Yaeshima T, Iwatsuki K, Yoshie H / Inhibitory effect of lactoferrin on growth and biofilm of Porphyromonas gingivalis and Prevotella intermedia. / Antimicrob Agents Chemother. / 53 / 3308 / 3316 / 2009 / Online Journal

Domon H, Honda T, Oda T, Yoshie H, Yamazaki K. / Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis. / J Leukoc Biol. / 83 / 672 / 679 / 2008 / Online Journal

Harada M, Kenmotsu S, Nakasone N, Nakakura-Ohshima K, Ohshima H. / Cell dynamics in the pulpal healing process following cavity preparation in rat molars. / Histochem Cell Biol. / 130 / 773 / 783 / 2008 / Online Journal

Honda T, Aoki Y, Takahashi N, Maekawa T, Nakajima T, Ito H, Tabeta K, Okui T, Kajita K, Domon H, Yamazaki K. / Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. / Clin Chim Acta. / 395 / 137 / 141 / 2008 / Online Journal

Honma Y, Sugita N, Kobayashi T, Abiko Y, Yoshie H / Lower antibody response to Porphyromonas gingivalis associated with FcgammaRIIb polymorphism. / J Periodont Res. / 43 / 706 / 711 / 2008 / Online Journal

Ikezawa-Suzuki I, Shimada Y, Tai H, Komatsu Y, Tanaka A, Yoshie H. / Effects of treatment on soluble tumour necrosis factor receptor type 1 and 2 in chronic periodontitis. / J Clin Periodontol. / 35 / 961 / 968 / 2008 / Online Journal

Komatsu Y, Galicia JC, Kobayashi T, Yamazaki K, Yoshie H. / Association of interleukin-1 receptor antagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method. / Int J Immunogenet. / 35 / 165 / 170 / 2008 / Online Journal

Kubota T, Itagaki M, Hoshino C, Nagata M, Morozumi T, Kobayashi T, Takagi R, Yoshie H. / Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue. / J Periodontol. / 79 / 166 / 173 / 2008 / Online Journal

Kubota T, Itagaki M, Morozumi T, Maruyama S, Nakasone N, Saku T, Yoshie H. / A case report of multiple-drug-induced gingival overgrowth with TIMP-3 over-expression. / Oral Med and Pathol. / 12 / 127 / 134 / 2008 / Online Journal

Murata M, Okuda K, Kubo K, Kuroyanagi Y, Wolff LF, Yoshie H / Root coverage with cultured gingival dermal substitute composed of gingival fibroblasts and matrix. A case series / Int J Periodontics Restorative Dent / 28(5) / 461 / 467 / 2008 / Online Journal

Nakajima T, Amanuma R, Ueki-Maruyama K, Oda T, Honda T, Ito H, Yamazaki K / CXCL13 expression and follicular dendritic cells in relation to B-cell infiltration in periodontal disease tissues. / J Periodont Res. / 43 / 635 / 641 / 2008 / Online Journal

Okui T, Ito H, Honda T, Amanuma R, Yoshie H, Yamazaki K. / Characterization of CD4+FOXP3+ T-cell clones established from chronic inflammatory lesion. / Oral Microbiol Immunol. / 23 / 49 / 54 / 2008 / Online Journal

Suzuki H, Amizuka N, Oda K, Noda M, Ohshima H, Maeda T / Histological and elemental analyses of impaired bone mineralization in klotho- deficient mice. / J. Anat. / 212 / 275 / 285 / 2008 / Online Journal

Suzuki H, Amizuka N, Oda K, Noda M, Ohshima H, Maeda T / Involvement of the klotho protein in dentin formation and mineralization. / Anat. Rec. / 291 / 183 / 190 / 2008 / Online Journal

Takamori Y, Suzuki H, Nakakura-Ohshima K, Cai J, Cho SW, Jung HS, Ohshima H. / Capacity of dental pulp differentiation in mouse molars as demonstrated by allogenic tooth transplantation. / J Histochem Cytochem. / 56 / 1075 / 1086 / 2008 / Online Journal

Yamamiya K, Okuda K, Kawase T, Hata K, Wolff LF, Yoshie H. / Tissue engineered cultured periosteum sheets combined with platelet-rich plasma and porous hydroxyapatite graft in treating human periodontal infrabony osseous defects: a comparative controlled clinical study. / J Periodontol. / 79 / 811 / 818 / 2008 / Online Journal

Gemmell E, Yamazaki K, Seymour GJ / The role of T cells in periodontal disease: homeostasis and autoimmunity / Periodontology 2000 / 43 / 14 / 40 / 2007 / Online Journal

Hamada N, Watanabe K, Tahara T, Nakazawa K, Shibata Y, Ishida I, Kobayashi T, Yoshie H, Abiko Y, Umemoto T / The r40-kDa OMP human monoclonal antibody protects against Porphyromonas gingivalis –induced bone loss in rat. / J. Periodontol. / 78(5) / 933 / 939 / 2007 / Online Journal

Hasegawa T, Suzuki H, Yoshie H, Ohshima H / Influence of extended operation time and of occlusal force on determination of pulpal healing pattern in replanted mouse molars. / Cell Tissue Res. / 329(2) / 259 / 272 / 2007 / Online Journal

Kajita K, Honda T, Amanuma R, Domon H, Okui T, Ito H, Yoshie H, Tabeta K, Nakajima T, Yamazaki K / Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis. / Oral Microbiol Immunol. / 22(6) / 398 / 402 / 2007 / Online Journal

Kawase T, Okuda K, Yoshie H / Extracellular ATP and ATPrS suppress the proliferation of human periodontal ligament cells by different mechanisms. / J. Periodontol. / 78(4) / 748 / 756 / 2007 / Online Journal

Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, Sumida T, Gejyo F, Yoshie H / The interleukin-1 and Fcg receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis. / J. Periodontol. / 78(12) / 2311 / 2318 / 2007 / Online Journal

Kobayashi T, Ito S, Yasuda K, Kuroda T, Yamamoto K, Sugita N, Tai H, Narita I, Gejyo F, Yoshie H / The combined genotypes of stimulatory and inhibitory Fcg receptor associated with systemic lupus erythematosus and periodontitis in Japanese adults. / J. Periodontol. / 78(3) / 467 / 474 / 2007 / Online Journal

Nishizawa R, Nagata M, Noman AA, Kitamura N, Fujita H, Hoshina H, Kubota T, Itagaki M, Shingaki S, Ohnishi M, Kurita H, Katsura K, Saito C, Yoshie H, Takagi R / The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.Journal / BMC Cancer. / 7 / 187 / 187 / 2007 / Online Journal

Watanabe K, Murata M, Nagamori T, Yamaguchi T, Yoshie H / Effects of CO2 Laser Treatment Combined with Scaling and Rpt Planing on Periodontal Pockets in Chronic Periodontitis Patients. / 日本歯周病学会会誌 / 49(2) / 130 / 138 / 2007 /

Yamamoto K, Kobayashi T, Sugita N, Tai H, Yoshie H. / The FcgRIIa polymorphism influences production of interleukin-1 by mononuclear cells / Int. J. Immuno. genet. / 34 / 369 / 372 / 2007 / Online Journal

Yamazaki K, Honda T, Domon H, Okui T, Kajita K, Amanuma R, Kudoh C, Takashiba S, Kokeguchi S, Nishimura F, Kodama M, Aizawa Y, Oda H. / Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. / Clin Exp Immunol. / 149 / 445 / 452 / 2007 / Online Journal

Yoshie H, Kobayashi T, Tai H, Galicia JC / The role of genetic polymorphisms in periodontitis. / Periodontol 2000. / 43(2) / 102 / 132 / 2007 / Online Journal

Yoshie H, Tai H, Kobayashi T, Oda-Gou E, Nomura Y, Numabe Y, Ito K, Kurihara H, Kamoi K / Salivary enzyme levels after scaling and IL-1 genotypes in Japanese with chronic periodontitis. / J. Periodontol. / 78(3) / 498 / 503 / 2007 / Online Journal

Amanuma R, Nakajima T, Yoshie H, Yamazaki K / Increased infiltration of CD1d+ and natural killer T cells in periodontal disease tissues / J Periodont Res / 41(1) / 73 / 79 / 2006 / Online Journal

Casrouge A, Zhang SY, Eidenschenk C, Jouanguy E, Puel A, Yang K, Alcais A, Picard C, Mahfoufi N, Nicolas N, Lorenzo L, Plancoulaine S, Senechal B, Geissmann F, Tabeta K, Hoebe K, Du X, Miller RL, Heron B, Mignot C, de Villemeur TB, Lebon P, Dulac O, Rozenberg F, Beutler B, Tardieu M, Abel L, Casanova JL / Herpes simplex virus encephalitis in human UNC-93B deficiency / Science / 314(5797) / 308 / 312 / 2006 / Online Journal

Galicia JC, Tai H, Komatsu Y, Shimada Y, Ikezawa I, Yoshie H / Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population / J Clin Periodontol / 33(10) / 704 / 709 / 2006 / Online Journal

Honda T, Domon H, Okui T, Kajita K, Amanuma R, Yamazaki K / Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions / Clin Exp Immunol / 144(4) / 35 / 40 / 2006 / Online Journal

Janssen E, Tabeta K, Barnes MJ, Rutschmann S, McBride S, Bahjat KS, Schoenberger SP, Theofilopoulos AN, Beutler B, Hoebe K / Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway / Immunity / 24(6) / 787 / 799 / 2006 / Online Journal

Kawase T, Okuda K, Yoshie H / A hepatocyte growth factor (HGF)/receptor autocrine loop regulates constitutive self-renewal of human periodontal ligament cells but reduces sensitivity to exogenous HGF / J Periodontol / 77(10) / 1723 / 1730 / 2006 / Online Journal

Kobayashi T, Kaneko S, Tahara T, Hayakawa M, Abiko Y, Yoshie H / Antibody responses to Porphyromonas gingivalis hemagglutinin A and outer membrane protein in chronic periodontitis / J. Periodontol / 77(3) / 364 / 369 / 2006 / Online Journal

Meehan TP, Tabeta K, Du X, Woodward LS, Firozi K, Beutler B, Justice MJ / Point mutations in the melanocortin-4 receptor cause variable obesity in mice / Mamm Genome / 17(12) / 1162 / 1171 / 2006 / Online Journal

Murata M, Momose M, Okuda K, Ninagawa Y, Ueda M, Yoshie H / Immunohistochemical localization of cytokeratin 19, involucrin and proliferationg cell nuclear antigen (PCNA) in cultured human gingivalepithelial sheets / J the International Academy of Periodontology / 8 (1) / 33 / 38 / 2006 / Online Journal

Nakasone N, Yoshie H, Ohshima H / An immunohistochemical study of the expression of heat-shock protein-25 and cell proliferation in the dental pulp and enamel organ during odontogenesis in rat molars / Arch Oral Biol / 51(5) / 378 / 386 / 2006 / Online Journal

Nakasone N, Yoshie H, Ohshima H / The relationship between the termination of cell proliferation and expression of heat-shock protein-25 in the rat developing tooth germ / Eur J Oral Sci / 114(4) / 302 / 309 / 2006 / Online Journal

Yamada K, Yamaura J, Katoh M, Hata K, Okuda K, Yoshie H / Fabrication of cultured oral gingiva by tissue engineering techniques without materials of animal origin / J Periodontol / 77(4) / 672 / 677 / 2006 / Online Journal

Zhang J, Raper A, Sugita N, Hingorani R, Salio M, Palmowski MJ, Cerundolo V, Crocker PR / Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors / Blood / 107(9) / 3600 / 3608 / 2006 / Online Journal

Zhang X, Niessner A, Nakajima T, Ma-Krupa W, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM / Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque / Circ Res / 98(4) / 524 / 531 / 2006 / Online Journal

Honda T, Oda T, Yoshie H, Yamazaki K / Effects of Porphyromonas gingivalis antigens and proinflammatory cytokines on human coronary artery endothelial cells. / Oral Microbiol Immunol / 20(2) / 82 / 88 / 2005 / Online Journal

Ikezawa I, Tai H, Shimada Y, Komatsu Y, Galicia JC, Yoshie H / Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis / J Clin Periodontol / 32(10) / 1047 / 1054 / 2005 / Online Journal

Ito H, Honda T, Domon H, Oda T, Okui T, Amanuma R, Nakajima T, Yamazaki K / Gene expression analysis of the CD4 T-cell clones derived from gingival tissues of periodontitis patients / Oral Microbiol Immunol / 20(6) / 382 / 386 / 2005 / Online Journal

Kawase T, Okuda K, Burns DM / Immature oseoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that differentially respond to [Cys(Acm)2,7]-CGRP and CGRP8-37 / Am J Physiol Cell Physiol / 289 / C811 / C818 / 2005 / Online Journal

Kawase T, Okuda K, Saito Y, Amizuka N, Suzuki H, Yoshie H / Platelet-rich plasma (PRP) provides nucleus for mineralization in cultures of partially differentiated periodontal ligament cells / In Vitro Cell. Dev. Biol. / 41 / 171 / 176 / 2005 / Online Journal

Kawase T, Okuda K, Saito Y, Yoshie H / In vitro evidence that the biological effects of platelet-rich plasma on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-ß or platelet-derived growth factor / J Periodontol / 76(5) / 760 / 767 / 2005 / Online Journal

Komatsu Y, Tai H, Galicia JC, Shimada Y, Endo M, Akazawa K, Yamazaki K, Yoshie H / Interleukin-6 (IL-6) –373 A9T11 allele is associated with reduced susceptibility to chronic periodontitis in Japanese subjects and decreased serum IL-6 level. / Tissue Antigens / 65 / 110 / 114 / 2005 / Online Journal

Murata M, Momose M, Okuda K, Ninagawa Y, Ueda M, Yoshie H / Immunohistochemical localization of cytokeratin19, involucrin and PCNA in human cultured gingival epithelial sheets. / J Int Acad Periodontol / 7 (4) / 129 / 134 / 2005 / Online Journal

Nakajima T, Ueki-Maruyama K, Oda T, Ohsawa Y, Ito H, Seymour GJ, Yamazaki K / Regulatory T-cells infiltrate Periodontal Disease Tissues / J Dent Res / 84(7) / 639 / 643 / 2005 / Online Journal

Ogino M, Kido J, Bando M, Hayashi N, Wada C, Nagata T, Nishimura F, Soga Y, Takashiba S, Kubota T, Itagaki M, Shimada Y, Tai H, Yoshie H, Yamazaki N, Shinohara Y, Kataoka M / {alpha}2 Integrin +807 Polymorphism in Drug-induced Gingival Overgrowth / J Dent Res / 84(12) / 1183 / 1186 / 2005 / Online Journal

Ohshima H, Nakasone N, Hashimoto E, Sakai H, Nakakura-Ohshima K, and Harada H / The eternal tooth germ is formed at the apical end of continuously growing teeth. / Arch Oral Biol / 50(2) / 153 / 157 / 2005 / Online Journal

Okuda K, Tai H, Tanabe K, Suzuki H, Sato T, Saito Y, Wolff LF, Yoshie H / Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: a comparative controlled clinical study / J Periodontol / 76(6) / 890 / 898 / 2005 / Online Journal

Suzuki H, Amizuka N, Oda K, Li M, Yoshie H, Ohshima H, Noda M, and Maeda T / Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice / Arch Histol Cytol / 68 / 371 / 381 / 2005 / Online Journal

Takauchi A, Kobayashi T, Tahara T, Nakazawa K, Hayakawa M, Shibata Y, Ishida I, Abiko Y, Yoshie H / The trans-chromosomic mouse-derived human monoclonal antibody promotes phagocytosis of Porphyromonas gingivalis by neutrophils. / J Periodontol / 76 (5) / 18 / 23 / 2005 / Online Journal

Yamazaki K, Honda T, Oda T, Ueki-Maruyama K, Nakajima T, Yoshie Y, Seymour G.J / Effect of periodontal treatment on the CRP and proinflammatory cytokine levels in Japanese periodontitis patients. / J Periodont Res / 40(1) / 53 / 58 / 2005 / Online Journal

Yoshie H, Galicia JC, Kobayashi T, Tai H / Genetic polymorphisms and periodontitis / International Congress Series / 1284 / 131 / 139 / 2005 / Online Journal

Yoshihara A, Sugita N, Yamamoto K, Kobayashi T, Hirotomi T, Ogawa H, Miyazaki H, Yoshie H / FcgRIIIb Genotypes and Smoking in Periodontal Disease Progression among Community-Dwelling Older Adults in Japanese. / J Periodontol / 76 (2) / 250 / 255 / 2005 / Online Journal

Zhang X, Nakajima T, Goronzy JJ, Weyand CM / Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritis / Arthritis Rheum / 52(12) / 3839 / 3849 / 2005 / Online Journal

Gonzales J, Kobayashi T, Michel J, Mann M, Yoshie H, Meyle J. / Interleukin-4 gene polymorphisms in Japanese and Caucasian patients with aggressive periodontitis. / J Clin Periodontol / 31(5) / 384 / 389 / 2004 / Online Journal

Itagaki M, Kubota T, Tai H, Shimada Y, Morozumi T, Yamazaki K. / Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. / J Clin Periodontol / 31(9) / 764 / 769 / 2004 / Online Journal

Kaneko S, Kobayashi T, Yamamoto K, Jansen MD, van de Winkel JGJ, Yoshie H. / A novel polymorphism of FcaRI(CD89) associated with aggressive periodontitis. / Tissue antigen / 63(6) / 582 / 527 / 2004 / Online Journal

Okuda K, Momose M, Murata M, Saito Y, Inoie M, Shinohara C, Wolff LF, Yoshie H. / Treatment of Chronic Desquamative Gingivitis Using Tissue Engineered Human Cultured Gingival Epithelial Sheets: A Case Report. / Int J Periodontics Restorative Dent / 24(2) / 119 / 125 / 2004 / Online Journal

Shimada Y, Tai H, Endo M, Kobayashi T, Akazawa K, Yamazaki K, Yoshie H. / Association of Tumor Necrosis Factor Receptor Type 2 +587 Gene Polymorphism with Severe Chronic Periodontitis. / J Clin Periodontol. in press. / 31(5) / 463 / 469 / 2004 / Online Journal

Yamamoto K, Kobayashi T, Grossi S, Ho AW, Genco RJ, Yoshie H, De Nardin E. / Association of Fcg receptor IIa genotype with chronic periodontitis in Caucasians. / J Periodontol / 75(4) / 517 / 522 / 2004 / Online Journal

Yamazaki K, Nakajima T. / Antigen specificity and T cell clonality in periodontal disease. / Periodontology 2000 / 35 / 75 / 100 / 2004 / Online Journal

Morozumi T, Kubota T, Sato T, Okuda K, Yoshie H. / Smoking cessation increases gingival blood flow and gingival crevicular fluid. / J Clin Periodontol. / 31(4) / 267 / 272 / 2004 / Online Journal

Yamazaki K, Ueki-Maruayama K, Honda T, Nakajima T, Seymour GJ. / Effect of periodontal treatment on the serum antibody levels to heat shock proteins. / Clin Exp Immunol. / 135(3) / 478 / 482 / 2004 / Online Journal

A.Miyazaki., T.Yamaguchi., J.Nishikata., K.Okuda., S.Suda., K.Orima., T.Kobayashi., K.Yamazaki., E.Yoshikawa.and H.Yoshie. / The effect of Nd:YAG abd CO2 laser treatment and ultrasonic scaling on the periodontal pockets of chronic periodontitis patients. / J Periodontol. / 74(2) / 175 / 180 / 2003 / Online Journal

K.Okuda., T.Kawase., M.Momose., M.Murata., Y.Saito., H.Suzuki., Wolff LF. and H.Yoshie. / Platelet-rich plasma(PRP) contains high levels of PDGF and TGF-β and modulates the proliferation of periodontal related cells in vitro. / J Periodontol. / 74(6) / 849 / 857 / 2003 / Online Journal

Kawase T, Okuda K, Burns DM. / Immature human osteoblastic MG63 cells predominantly express a subtype 1-like CGRP receptor that inactivates extracellular signal response kinase by a cAMP-dependent mechanism. / Eur J Pharmacol. / 470(3) / 125 / 137 / 2003 / Online Journal

Nakajima T., Goek O., Zhang X., Kopecky S.L., Frye R.L., Goronzy J.J., Weyand C.M. / De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. / Circ Res. / 93(2) / 106 / 113 / 2003 / Online Journal

T,Kawase., K.Okuda., Wolff LF.and H.Yoshie. / Platelet-rich plasma(PRP)-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cell cultures. / J Periodontol. / 74(6) / 858 / 864 / 2003 / Online Journal

T.Kobayashi., S.Ito., K.Yamamoto., H.Hasegawa., N.Sugita., T.Kuroda., I.Narita., K.Yasuda., M.Nakano., F.Gejyo. and H.Yoshie. / Risk of Periodontitis in Systemic Lupus Erythematosus is Associated with FcγReceptor Polymorphisms. / J Periodontol. / 74(3) / 378 / 384 / 2003 / Online Journal

T.Oda., H.Yoshie.and K.Yamazaki. / Porphyromonas gingivalis antigen preferentially stimulates T cells to express Il-17 but not receptor activator of NF-κB ligand in vitro. / Oral Microbiol Immunol. / 18(1) / 30 / 36 / 2003 / Online Journal

van der Pol WL, Jansen MD, Sluiter WJ, van de Sluis B, Leppers-van de Straat FG, Kobayashi T, Westendorp RG, Huizinga TW, van de Winkel JG. / Evidence for non-random distribution of Fcγ receptor genotype combinations. / Immunogenetics. / 55(4) / 240 / 246 / 2003 / Online Journal

Yamazaki K, Ueki-Maruyama K, Oda T, Tabeta K, Shimada Y, Tai H, Nakajima T, Yoshie H, Herawati D, Seymour GJ. / Single nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population. / J Dent Res. / 82(8) / 612 / 616 / 2003 / Online Journal

Yamazaki K, Yoshie H, Seymour GJ. / T cell regulation of the immune response to infection in periodontal diseases. / Histology and Histopathology. / 18(3) / 889 / 896 / 2003 / Online Journal

Yasuda K, Sugita N, Kobayashi T, Yamamoto K, Yoshie H. / FcγRIIB Gene Polymorphisms in Japanese Periodontitis Patients. / Genes Immun. / 4(8) / 541 / 546 / 2003 / Online Journal

E.Gemmell., K.Yamazaki.and Seymour GJ. / Destructive periodontitis lesions are determined by the nature of the lymphocytic response. / Crit Rev Oral Biol Med. / 13(1) / 17 / 34 / 2002 / Online Journal

H.Itoh., Y.Ohsawa., H.Yoshie.and K.Yamazaki. / Oligoclonal accumulations of T cell clones in gingivitis and periodontal lesions. / Oral Microbiol Immunol. / 17(2) / 324 / 329 / 2002 / Online Journal

H.Suzuki, T.Inagawa, H.Yoshie , Jun Li , K.Yamabe , N.Yanaihara, Ulo Langel. and T.Maeda. / Expression of galanin receptor-1(GALR1) in the rat trigeminal ganglia and molar teeth. / Neuroscience Research / 42 / 197 / 207 / 2002 / Online Journal

H.Tai., M.Endo., Y.Shimada., E.Go., K.Orima., T.Kobayashi., K.Yamazaki.and H.Yoshie. / Association of interleukin-1 receptor antagonist gene polymorphisms with early-onset periodontitis in Japanese. / J Clin Periodontol. / 29 / 882 / 888 / 2002 / Online Journal

K.Ueki., K.Tabeta., H.Yoshie.and K.Yamazaki. / Self-heat shock protein 60 induces tumor necrosis factor-αin monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease. / Clin Exp Immunol. / 157 / 72 / 77 / 2002 / Online Journal

K.Yamazaki., Y.Ohsawa., K.Tabeta., H.Ito., K.Ueki., T.Oda., H.Yoshie. and Seymour G.J. / Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients. / Infect Immun. / 70(5) / 2492 / 2501 / 2002 / Online Journal

Kawase, T., Okuda, K., Yoshie, H. and Burns, DM. / Anti-TGF-β antibody blocks enamel matrix derivative-induced up-regulation of p21WAF1/cip1 and prevents its inhibitation of human oral epithelial cell proliferation. / J Periodontol Res. / 37(4) / 255 / 262 / 2002 / Online Journal

M.momose., M.Murata., Y.Kato., K.Okuda., K.Yamazaki., C.Shinohara. and H.Yoshie. / Vascular endothelial growth factor and transforming growth factor-α and -β released from human cultured gingival epithelial sheets by tissue engineering techniques. / J Periodontol. / 73(7) / 748 / 753 / 2002 / Online Journal

Murata, M., Tatsumi, J., Kato, Y., Suda, S., Nunokawa, Y., Kobayashi, Y., Takeda, H., Araki, H., Shin, K., Okuda, K., Miyata, T., and Yoshie, H. / Osteocalcin, Deoxypyridinoline and Interleukin-1βin peri-implant clevicular fluid of patients with peri-implantitis. / Clin Oral Implants Res. / 13(6) / 637 / 643 / 2002 / Online Journal

Nakajima T., Schulte S., Warrington K.J., Kopecky S.L., Fry R.L., Goronzy J.J.and Weyand C.M. / T-cell-mediated lysis of endothelial cells in acute coronary syndromes. / Circulation / 105(5) / 570 / 575 / 2002 / Online Journal

Saito, Y., Yoshizawa, T., Takizawa, F., Ikegame, M., Ishibashi, O., Okuda, K., Hara, K., Ishibashi, K., Obinata, M., and Kawashima, H. / A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. / J Cell Sci. / 115(Pt21) / 4191 / 4200 / 2002 / Online Journal

Endo M., Tai H., Tabeta K., Kobayashi T., Yamazaki K., and Yoshie H. / Analysis of single nucleotide polymorphisms in the 5'-flanking region of tumor necrosis factor alpha gene in Japanese patients with early-onset periodontitis / J. Periodontol / 72 / 1554 / 1559 / 2001 / Online Journal

Kawase T., Okuda K., Momose M., Kato K., Yoshie H., Burns DM. / Enamel matrix derivative (EMDOGAIN®) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. / J Periodont Res / 36 / 367 / 376 / 2001 / Online Journal

Kobayashi T., Yamamoto K., Sugita N., van der Pol W-L., Yasuda K., Kaneko S., van de Winkel J.G.J., Yoshie H. / The Fcg receptor genotype as a severity factor for adult periodontits in Japanese patients. / J Periodontol / 72 / 1324 / 1331 / 2001 / Online Journal

Kobayashi T., Yamamoto K., Sugita N., van Spriel A.B., Kaneko S., van de Winkel J.G.J., Yoshie H. / Effective in vitro clearance of Porphyromonas gingivalis by Fca Receptor I (CD89) on gingival crevicular neutrophils. / Infect Immun / 69 / 2935 / 2942 / 2001 / Online Journal

Kubota T., Morozumi T., Shimizu K., Sugita N., Kobayashi T., Yoshie H. / Differential gene expression in neutrophils from patients with generalized aggressive periodontitis. / J Periodont Res / 36 / 390 / 397 / 2001 / Online Journal

Morozumi T., Kubota T., Sugita N., Ohsawa Y., Yamazaki K., Yoshie H.: / Elevated mRNA expression for supervillin and vascular endothelial growth factor in human neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis. / J Periodont Res / 36 / 160 / 168 / 2001 / Online Journal

Okuda K., Miyazaki A., Momose M., Murata M., Nomura T., Kubota T., Wolff L.F., Yoshie H. / Levels of Tissue inhibitor of metalloproteinases-1, matrix metalloproteinases-1 and -8 levels in gingival crevicular fluid following treatment with enamel matrix derivative (EMDOGAIN®). / J Periodont Res / 36 / 309 / 316 / 2001 / Online Journal

Sugita N., Kobayashi T., Ando Y., Yoshihara A., Yamamoto K., van de Winkel J.G.J., Miyazaki H., Yoshie H. / Increased frequency of FcgRIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population. / J Dent Res / 80 / 914 / 918 / 2001 / Online Journal

Tabeta K., Yoshie H., Yamazaki K. / Characterization of serum antibody to Actinobacillus actinomycetemcomitans GroEL-like protein in periodontitis patients and healthy subjects. / Oral Microbiol Immunol / 16 / 290 / 295 / 2001 / Online Journal

Takeishi H., Irie K., Okuda K., Ozawa H., Yajima T., Ejiri S. / Molded bone augumentation by a combination of barrier membrane and recombinant human bone morphogenetic protein-2. / Oral Diseases / 7 / 281 / 286 / 2001 / Online Journal

Ueki K., Tabeta K., Yoshie H., Yamazaki K. / Self-heat shock protein 60 induces tumor necrosis facterα in monocyte-derived macrophase : possible role in chronic inflammatory periodontal desease. / Clinical and experimental immunology / 127 / 72 / 77 / 2001 / Online Journal

Yamamoto K., Sugita N., Kobayashi T., Okuda K., van de Winkel J.G.J., Yoshie H. / Evidence for a novel polymorphism affecting both N-linked glycosylation and ligand binding of the IgG receptor IIIB(CD16). / Tissue Antigens / 57 / 363 / 366 / 2001 / Online Journal

Yamazaki K., Ohsawa Y., Yoshie H. / Elevated proportion of natural killer T cells in periodontitis lesion;a common feature of chronic inflammatory diseases. / American J Pathol / 158 / 1391 / 1398 / 2001 / Online Journal

Yamazaki K., Tabeta K., Nakajima T., Ohsawa Y., Ueki K., Itoh H., Yoshie H. / Interleukin-10 gene promoter polymorphism in japanese patients with adult and early-onset periodotitis. / J Clin Periodont / 28 / 828 / 832 / 2001 / Online Journal

Yasuda K., Sugita N., Yamamoto K., Kobayashi T., and Yoshie H. / Seven single nucleotide substitutions in human Fcg receptor IIB gene. / Tissue Antigens / 58 / 339 / 342 / 2001 / Online Journal

Yoshihara A., Sugita N., Yamamoto K., Kobayashi T., Miyazaki H., Yoshie H. / Analysis of Vitamin D and Fcg Receptor Polymorphisms in in Japanese Patients with Generalized Early-Onset Periodontitis. / J. Dent. Res. / 80 / 2051 / 2054 / 2001 / Online Journal

Aoyagi T, Yamazaki K, Kabasawa-Katoh Y, Nakajima T, Yamashita N, Yoshie H, Hara K / Elevated CTLA-4 expression on CD4 T cells from periodontitis patients stimulated with Porphyromonas gingivalis outer membrane antigen. / Clin Exp Immunol / 119 / 280 / 286 / 2000 / Online Journal

Kawase T, Okuda K, Yoshie H, Burns DM / Cytostatic action of enamel matrix derivative (EMDOGAIN®) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. / J Periodont Res / 35 / 291 / 300 / 2000 / Online Journal

Kobayashi T, Sugita N, van der Pol W-L, Nunokawa Y, Westerdaal NAC, Yamamoto K, van de Winkel JGJ, Yoshie H / The Fcg receptor genotype as a risk factor for generalized early-onset periodontitis in Japanese patients. / J Periodontol / 71 / 1425 / 1432 / 2000 / Online Journal

Kobayashi T, van der Pol W-L, Sugita N, Westerdaal NAC, Yoshie H, Horigome T, van de Winkel JGJ, Hara K / Relevance of IgG receptor IIIb (CD16) polymorphism to handling of Porphyromonas gingivalis: implications for the pathogenesis of adult periodontitis. / J Periodont Res / 35 / 65 / 73 / 2000 / Online Journal

Murata M, Cheng J, Horino K, Hara K, Shimokawa H, Saku T / Enamel proteins and extracellular matrix molecules are co-localized in the pseudocystic stromal space of adenomatoid odontogenic tumor. / zx / 29 / 483 / 490 / 2000 / Online Journal

Nomura T, Ishii A, Shimizu H, Taguchi N, Yoshie H, Kusakari H, Hara K / Tissue inhibitor of metalloproteinases-1, matrix metalloproteinases-1 and -8, and collagenase activity levels in peri-implant crevicular fluid after implantation. / Clin Oral Impl Res / 11 / 430 / 440 / 2000 / Online Journal

Ohsawa Y, Yamazaki K, Nakajima T, Hara K / Clonal accumulation of T-cells bearing Vb6 T-cell receptor in chronic inflammatory periodontal disease. / Oral Microbiol Immunol / 15 / 211 / 217 / 2000 / Online Journal

Okuda K, Miyazaki A, Momose M, Murata M, Yokoyama S, Yonezawa Y, Nomura T, Wolff LF, Yoshie H / Enamel matrix derivative(EMD) in the treatment of human infrabony periodontal osseous defects. 2000 Annual meeting abstracts: Meeting Reports. / J Periodontol / 71 / 1913 / / 2000 /

Okuda K, Miyazaki A, MomoseM, Murata M, Nomura T, Kubota T, Wolff LF, Yoshie H / Tissue inhibitor of metalloproteinases-1, matrix metalloproteinases-1 and -8 levels in gingival crevicular fluid following treatment with enamel matrix derivative (EMDOGAIN®). / J Periodont Res / 36 / 309 / 316 / 2000 / Online Journal

Okuda K, Momose M, Miyazaki A, Murata M, Yokoyama S, Yonezawa Y, Wolff LF, Yoshie H / Enamel matrix derivative in the treatment of human infrabony periodontal osseous defects. / J Periodontol / 71 / 1821 / 1828 / 2000 / Online Journal

Tabeta K, Yamazaki K, Akashi S, Miyake K, Kumada H, Umemoto T, Yoshie H / Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts. / Infect Immun / 68 / 3731 / 3735 / 2000 / Online Journal

Tabeta K, Yamazaki K, Hotokezaka H, Yoshie H, Hara K / Elevated humoral immune response to heat shock protein 60 family in periodontitis patients. / Clin Exp Immunol / 120 / 285 / 293 / 2000 / Online Journal

van de Straat FGJL, van der Pol W-L, Jansen MD, Sugita N, Yoshie H, Kobayashi T, van de Winkel JGJ / A novel PCR-based method for direct Fcg receptor IIIa(CD16) allotyping. / J Immunol Methods / 242 / 127 / 132 / 2000 / Online Journal

Yamazaki K, Nakajima T, Ohsawa Y, Tabeta K, Yoshie H, Sakurai K, Seymour GJ / Selective expansion of T cells in gingival lesions of patients with chronic inflammatory peirodontal disease. / Clin Exp Immunol / 120 / 154 / 161 / 2000 / Online Journal

Izumi K, Nakajima T, Maeda T, Irie T, Murata M, Saku T / Polypoid mass of the gingiva. / Oral Surg Oral Med Oral Pathol Oral Radiol Endod / 88 / 117 / 121 / 1999 / Online Journal

Kawase T, Okuda K, Wu C-H, Yoshie H, Hara K, Burns DM / Calcitonin gene-related peptide acts as a mitogen for human Gin-1 gingival fibroblasts by activating the MAP kinase signalling pathway. / J Periodont Res / 34 / 160 / 168 / 1999 / Online Journal

Kubota T, Morozumi T, Yoshie H / Differential gene expression of human neutrophils induced by lipopolysaccharide from Porphyromonas gingivalis using RAP-PCR. / Dent Jpn / 35 / 109 / 112 / 1999 / Online Journal

Orima K, Yamazaki K, Aoyagi T, Hara K / Differential expression of costimulatory molecules in chronic inflammatory periodontal disease tissue. / Clin Exp Immunol / 115 / 153 / 160 / 1999 / Online Journal

Suda S, Machida N, Momose M, Yamaki M, Seki Y, Yoshie H, Hanada K, Hara K / A multiparametric analysis of occlusal and periodontal jaw reflex characteristics in adult skeletal mandibular protrusion before and after orthognathic surgery. / J Oral Rehabil / 26 / 686 / 690 / 1999 / Online Journal

Sugita N, Yamamoto K, Kobayashi T, van der Pol W-L, Horigome T, Yoshie H, van de Winkel JGJ, Hara K / Relevance of FcgRIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients. / Clin Exp Immunol / 117 / 350 / 354 / 1999 / Online Journal

Kabasawa Y, Ejiri S, Matsuki Y, Hara K, Ozawa H / Immunoreactive localization of transforming growth factor-b type II receptor-positive cells in rat tibiae. / Bone / 22 / 93 / 98 / 1998 / Online Journal

Nakajima T, Yamazaki K, Sakurai K, Gemmell E, Seymoour GJ, Hara K / Detection of clonotypic changes of T cells after stimulation with Porphyromonas gingivalis. / Oral Microbiol Immunol / 13 / 238 / 245 / 1998 / Online Journal

Nomura T, Ishii A, Oishi Y, Kohma H, Hara K / Tissue inhibitors of metalloproteinases level and collagenase activity in gingival crevicular fluid: the relevance to periodontal diseases. / Oral Diseases / 4 / 231 / 240 / 1998 / Online Journal

Okuda K, Murata M, Sugimoto M, Nomura T, Wu C-H, Hara K / Comparison of guided tissue regeneration procedure to conventional flap surgery in treating intrabony and class II furcation defects, and analysis of factors affecting the prognosis following GTR. / J Japan Soc Periodont / 40 / 358 / 370 / 1998 / Online Journal

Okuda K, Murata M, Sugimoto M, Saito Y, Kabasawa Y, Yoshie H, Saku T, Hara K / TGF-b1 influences early gingival wound healing in rats: an immunohistochemical evaluation of stromal remodelling by extracellular matrix molecules and PCNA. / J Oral Pathol Med / 27 / 463 / 469 / 1998 / Online Journal

Sugita N, Kimura A, Matsuki Y, Yamanoto T, Yoshie H, Hara K / Activation of transcription factors and IL-8 expression in neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis. / Inflammation / 22 / 253 / 267 / 1998 / Online Journal






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