Academic Organization


http://www.dent.niigata-u.ac.jp/material/material.html




- Identification and characterization of an oral keratinocyte progenitor/stem cell subpopulation

We explore biology of an oral keratinocyte progenitor/stem cell subpopulation by conducting a comprehensive approach including detection of potential biological markers of progenitor/stem cells and their intraepithelial localization. Subsequently, we attempt to develop an optimal in vitro condition to maintain an oral keratinocyte progenitor/stem cell subpopulation.

- Development of non-invasive approaches to evaluate a tissue-engineered oral mucosa

We develop multiple, more biologically specific and non-invasive approaches to evaluate a tissue-engineered oral mucosa for intraoral grafting. These novel approaches can be utilized as release criteria of the grafts to assure their quality during manufacturing tissue-engineered oral mucosa on clinical applications in our University hospital.

- Pharmacological manipulations to fabricate a more consistent tissue-engineered oral mucosa
- Application of fish scale collagen as a scaffold for tissue regeneration
- Constructing a 3D in vitro model to elucidate histological changes of oral mucosa by - Bisphosphonates - Denture-wearing
- By harnessing our platform technique of culturing oral mucosa keratinocytes and fibroblasts, we develop 3D in vitro models to elucidate the patho-physiological mechanism of oral mucosa lesions and to analyze normal biological phenomena in healthy environment on molecular base.
- Research on investment for dental titanium casting

Research on the reaction layer between investment and titanium during the casting process, and its influence to some properties of casting.

- Research on the surface treatments and the biocompatibility of titanium

Improvement of biocompatibility by performing electrochemical treatment to the titanium surface.

- Research on the corrosion properties of various dental alloys
- Research on setting expansion pressure of dental plaster and stone
- Influence of grinding and polishing dust of dental materials on human body

Extensive research on the influence of the fine particles on hyumann health.





Kenji IZUMIProfessordepartment of oral anatomy, faculty of dentistry
Seigo OKAWAAssociate professordepartment of dental materials and technology, faculty of dentistry
Mitsugu KANATANIAssistant professordepartment of dental materials and technology, faculty of dentistry
Hiroko KATOAssistant professordivision of reconstructive surgery for oral and maxillofacial





Smith MH, Izumi K, Feinberg SE / Chapter 2.11, Tissue engineering. / Eds by John Langdon, Mohan Patel, Robert Ord, Peter Brennan / Operative Oral and Maxillofacial Surgery / 3rd Ed / CPC Press / London / 2016 / in press / in press /

Smith MH, Izumi K, Feinberg SE / Chapter 2.11, Tissue engineering. / Eds by John Langdon, Mohan Patel, Robert Ord, Peter Brennan / Operative Oral and Maxillofacial Surgery / 3rd Ed / Hodder Arnold Health Sciences / London / 2014 / 137 / 146 /

Izumi K, Kato H, Feinberg SE / Chapter 53, Three-dimensional reconstruction of oral mucosa; Tissue engineering strategies. / Eds by Vishwakarma A, Sharpe P, Shi S, Wang X-P, Ramalingam M / Stem Cell Biology and Tissue Engineering in Dental Science / / Academic Press/Elsevier / Waltham, MA, USA / 2014 / 721 / 731 /



Uenoyama A, Kakizaki I, Shiomi A, Saito N, Hara Y, Saito T, Ohnuki H, Kato H, Takagi R, Maeda T, Izumi K. / Effects of C-xylopyranoside derivative on epithelial regeneration in an in vitro 3D oral mucosa model / Biosci Biotechnol Biochem / / in press / in press / 2016 / Online Journal

Kato H, Lo A, Kuo S, Nie S, Marcelo CL, Lubman DM, Feinberg SE / Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration. / MOJ Proteomics Bioinform / 2 / / / 2015 / Online Journal

Kato H, Marcelo CL, Washington JB, Bingham EL, Feinberg SE / Fabrication of Large Size Ex Vivo-Produced Oral Mucosal Equivalents for Clinical Application / Tissue Eng Part C Methods / 21 / 872 / 880 / 2015 / Online Journal

Kato H, Izumi K, Uenoyama A, Shiomi A, Kuo S, Feinberg SE / Hypoxia induces undifferentiated phenotype of oral keratinocytes in vitro / Cells Tissues Organs / 199 / 393 / 404 / 2015 / Online Journal

Shiomi A, Izumi K, Uenoyama A, Saito T, Saito N, Ohnuki H, Kato H, Kanatani M, Nomura S, Egusa H, Maeda T / Cyclic mechanical pressure-loading alters epithelial homeostasis in a three-dimensional in vitro oral mucosa model: Clinical implications for denture-wearers / J Oral Rehabil / 42 / 192 / 201 / 2015 / Online Journal

Kuo S, Zhou Y, Kim HM, Kato H, Kim RY, Bayar GR, Marcelo CL, Kennedy RT, Feinberg SE / Biochemical indicators of implantation success of tissue-engineered oral mucosa / J Dent Res / 94 / 78 / 84 / 2015 / Online Journal

Yamaga Y, Kanatani M, Nomura S / Usefulness of a rotation-revolution mixer for mixing powder-liquid reline material / J Prosthodont Res / 59 / 71 / 78 / 2015 / Online Journal

Winterroth F, Kato H, Kuo S, Feinberg SE, Hollister SJ, Fowlkes BJ, Hollman KW / High-frequency ultrasonic imaging of growth and development in manufactured engineered oral mucosal tissue surfaces / Ultrasound Med Biol / 40 / 2244 / 2251 / 2014 / Online Journal

Saito T, Izumi K, Shiomi A, Uenoyama A, Ohnuki H, Kato H, Terada M, Nozawa-Inoue K, Kawano Y, Takagi R, Maeda T / Zoledronic acid impairs re-epithelialization through down-regulation of integrin αvβ6 and transforming growth factor beta signalling in a three-dimensional in vitro wound healing model. / Int J Oral Maxillofac Surg / 43 / 373 / 380 / 2014 / Online Journal

Izumi K, Neiva RF, Feinberg SE / Intraoral grafting of tissue-engineered human oral mucosa. / Int J Oral Maxillofac Implants / 28 / 295 / 303 / 2013 / Online Journal

Kato H, Izumi K, Saito T, Ohnuki H, Terada M, Kawano Y, Nozawa-Inoue K, Saito C, Maeda T / Distinct expression patterns and roles of aldehyde dehydrogenases in normal oral mucosa keratinocytes: differential inhibitory effects of a pharmacological inhibitor and RNAi-mediated knockdown on cellular phenotype and epithelial morphology. / Histochem Cell Biol / 139 / 847 / 862 / 2013 / Online Journal

Khmaladze A, Ganguly A, Kuo S, Raghavan M, Kainkaryam R, Cole JH, Izumi K, Marcelo CL, Feinberg SE, Morris MD / Tissue-engineered constructs of human oral mucosa examined by Raman spectroscopy. / Tissue Eng Part C Methods / 19 / 299 / 306 / 2013 / Online Journal

Watanabe K, Okawa S, Kanatani M / Surface analysis of commercially pure titanium implant retrieved from rat bone Part 2: Biomolecular adsorption influenced by surface texture. / Niigata Dent J / 43 / 13 / 25 / 2013 / Online Journal

Izumi K, Marcelo CL, Feinberg SE / Enrichment of oral mucosa and skin keratinocyte progenitor/stem cells. / SKIN STEM CELLS Methods and Protocols / 989 / 293 / 303 / 2013 / Online Journal

Seigo Okawa, Kouichi Watanabe, Mitsugu Kanatani / Calcium phosphates deposited on titanium electrode surface-Part 1: Effect of the electrode polarity and oxide film on the deposited materials / Dent Mater J / 32 / 281 / 288 / 2013 / Online Journal

Han L, Okiji T, Okawa S / Morphological and chemical analysis of different precipitates on mineral trioxide aggregate immersed in different fluids / Dent Mater J / 29 / 512 / 517 / 2010 / Online Journal

Otawara Y, Ogasawara K, Kashimura H, Kubo Y, Ogawa A, Watanabe K / Mechanical characteristics and surface elemental composition of a Yasargil titanium aneurysm clips after long-term implantation / J Neurosurg / 112 / 1260 / 1262 / 2010 / Online Journal

Kaneko Y, Kikuchi N, Ishii Y, Kawabata Y, Moriyama H, Terada M, Suzuki E, Kobayashi M, Watanabe K and Hizawa N / Upper Lobe-Dominant Pulmonary Fibrosis Showing Deposits of Hard Metal Component in the Fibrotic Lesions / Internal Medicine / 49 / 2143 / 2145 / 2010 / Online Journal

Kimura I, Kanatani M, Watanabe K / Adhesion of hollow calcium-deficient hydroxyapatite microspheres onto titanium / Dent Mater J / 28 / 700 / 707 / 2009 / Online Journal

Okawa S, Homma K, Kanatani M, Watanabe K / Characterization of calcium phosphate deposited on valve metal by anodic oxidation with polarity inversion / Dent Mater J / 28 / 513 / 518 / 2009 / Online Journal

Otawara Y, Ogasawara K, Kubo Y, Kashimura H, Ogawa A, Watanabe K / Mechanical and surface properties of Yasargil Phynox aneurysm clips after long-term implantation in a patient with cerebral aneurysm / Neurosurg Rev / 32 / 193 / 197 / 2009 / Online Journal

Watanabe K., Okawa S., Kanatani M., Homma K. / Surface analysis of commercially pure titanium implant retrieved from rat bone. Part 1: Initial biological response of sandblasted surface. / Dent Mater J / 28 / 178 / 193 / 2009 / Online Journal

Okawa S., Watanabe K. / Chemical mechanical polishing of titanium with colloidal silica containing hydrogen peroxide – mirror polishing and surface properties. / Dent Mater J / 28 / 68 / 74 / 2009 / Online Journal

Shimizu H., Inoue S., Miyauchi H., Watanabe K., Takahashi Y. / Mould filling of Ag-Pd-Cu-Au and Ag-Zn-Sn-In alloy castings made using a rapidly prepared gypsum-bonded investment material. / Eur J Prosthodont Restor Dent / 16 / 177 / 180 / 2008 / Online Journal

Moriyama, H., Kobayashi, M., Takada, T., Shimizu, T., Terada, M., Narita, J., Maruyama, M., Watanabe, K., Suzuki, E., Gejyo, F., / Two-dimensional analysis of elements and mononuclear cells / Am J Respir Crit Care Med / 176 / 70 / 77 / 2007 / Online Journal

Hossain,A., Okawa,S., and Miyakawa,O. / Surface texture and composition of titanium brushed with toothpaste slurries of different pHs. / Dent Mater: / 23 / 186 / 192 / 2007 / Online Journal

Otawara, Y., Endo, M.M., Ogasawara, K.., Kubo, Y., Ogawa, A.., Watanabe, K. / Reliability of cobalt-chromium alloy aneurysm clips after long-term implantations in patients with cerebral aneurysms. / J Neurosurg / 105 / 713 / 716 / 2006 / Online Journal

Hayashi, Y., Kobayashi, H., Yamada, Y., Miyakawa, O., Tsujimoto, Y. / Effects of heat treatment on fatigue strength of occlusal rests cast with Ag-Pd-Cu-Au alloy. / Prosthodont Res Pract / 5 / 195 / 202 / 2006 /

Miyakawa,O., Okawa,S., and Kobayashi,M. / Abrading increases oxygen and hardness of titanium surface. / Dent Mater J / 25 / 13 / 19 / 2006 / Online Journal

Hossain,A., Okawa,S., and Miyakawa,O. / Effect of toothbrushing on titanium surface: An approach to understanding surface properties of brushed titanium. / Dent Mater / 22 / 346 / 352 / 2006 / Online Journal

Stegaroiu,R., Watanabe,N., Tanaka,M., Ejiri,S., Nomura,S., and Miyakawa,O. / Peri-mplant stress analysis in simulation models with or without trabecular bone structure. / Int J Prosthodont / 19 / 40 / 42 / 2006 / Online Journal

Hossain,A., Okawa,S., and Miyakawa,O. / Surface composition and texture of titanium polished with colloidal silica suspension and chromic oxide slurry. / Dent Mater J / 24 / 409 / 413 / 2005 / Online Journal

Keanini,RG., Watanabe,K., and Okabe,T. / Theoretical model of the two-chamber pressure casting process. / Metall & Mater Trans B / 36B / 283 / 292 / 2005 /

Baltag,I., Watanabe,K., and Miyakawa,O. / Internal porosity of cast titanium removable partial dentures ¾ Influence of sprue direction and diameter on porosity in simplified circumferential clasps. / Dent Mater / 21 / 530 / 537 / 2005 / Online Journal

Kitamura,E., Stegaroiu,R., Nomura,S., and Miyakawa,O. / Influence of marginal bone resorption on stress around an implant ¾ a three-dimensional finite element analysis. / J Oral Rehabili / 32 / 279 / 286 / 2005 / Online Journal

Okawa,S., Hossain,A., Kanatani,M., Watanabe,K., and Miyakawa,O. / Surface properties of electrochemically buffed titanium casting. / Dent Mater J / 23 / 504 / 511 / 2004 / Online Journal

Watanabe,K., Hashimoto,H., and Endo,MM. / Trace elements on the surface of titanium implants extracted from rat bone. / Biomed Res Trace Elements / 15 / 262 / 264 / 2004 /

Stegaroiu,R., Khraisat,A., Nomura,S., and Miyakawa,O. / Influence of superstructure materials on strain around an implant under 2 loading conditions. / Internat J Oral & Maxillofac Impl / 19 / 735 / 742 / 2004 / Online Journal

Shimizu,H., Watanabe,K., Okabe,T., and Takahashi,Y. / Mold filling of titanium castings using a 45° marginal edge. Internat / Chin J Dent / 4 / 67 / 71 / 2004 /

Mimura K., Watanabe K., Okawa S., Kobayashi M., and Miyakawa, O. / Morphological and chemical characterizations of the interface of a hydroxyapatite-coated implant. / Dent Mater J / 22 / 353 / 360 / 2004 / Online Journal

Kitamura,E., Stegaroiu,R., Nomura,S., and Miyakawa,O. / Biomechanical aspects of marginal bone resorption around osseointegrated implants: considerations based on a three-dimensional finite element analysis. / Clin Oral Impl Res / 15 / 401 / 412 / 2004 / Online Journal

Watanabe,K. and Okabe,T. / Casting pressure in two types of titanium casting equipment. / Mater Trans / 45 / 1653 / 1659 / 2004 /

Khraisat,A., Hashimoto,A., Nomura,S., and Miyakawa O. / Effect of lateral loading on abutment screw loosening of an external hexagon implant system. / J Prosthet Dent / 91 / 326 / 334 / 2004 / Online Journal

Hotta,N., Kanatani,M., Yonezawa,R., Yanagita,K., Tobitsuka,T., and Watanabe,T. / Properties of AlN powders synthesized by rapid nitridation of Al powder in floating system. / Mater Sci Forum / 426-432 / 4245 / 4250 / 2003 /

Gapido,CG., Kobayashi,H., Miyakawa,O., and Kohno,S. / Fatigue resistance of cast occlusal rests using Co-Cr and Ag-Pd-Cu-Au alloys. / The J Prosthet Dent. / 90 / 261 / 269 / 2003 / Online Journal

Tada,S., Stegaroiu,R., Kitamura,E., Miyakawa,O., and Kusakari,H. / Influence of Implant Design and Bone Quality on Stress/Strain Distribution in Bone Around Implant: A 3-dimensional Finite Element Analysis / Int J Oral Maxillofac Implants / 18 / 357 / 368 / 2003 / Online Journal

Kanatni,M., Miyakawa,O., and Hotta,N. / Prospective Demand for Fixed and Removable Dentures for Elderly and Dependent Elderly People in Japan / Dent in Jpn / 39 / 63 / 66 / 2003 /

Watanabe,K., Miyakawa,O., Takada,T., Okuno,O. and Okabe,T. / Casting behavior of titanium alloys in a centrifugal casting machine. / Biomater / 24 / 1737 / 1743 / 2003 / Online Journal

Khraisat,A., Stegaroiu,R., Nomura,S., and Miyakawa,O. / Fatigue resistance of two implant/abutment joint designs. / The J Prosthet Dent. / 88 / 604 / 610 / 2002 / Online Journal

Baltag,I., Watanabe,K., Kusakari,H., and Miyakawa,O. / Internal porosity of cast titanium removable partial dentures: Influence of sprue direction on porosity in circumferential clasps of a clinical framework design. / The J Prosthet Dent. / 88 / 151 / 158 / 2002 / Online Journal

Shimizu,H., Habu,T., Takada,Y., Watanabe,K., Okuno,O. and Okabe,T. / Mold filling of titanium alloys in two different wedge-shaped molds. / Biomater / 23 / 2275 / 2281 / 2002 / Online Journal

Watanabe,K., Miyakawa,O., and Kobayashi,M. / New method for quantitative mapping of metallic elements in tissue sections by electron probe microanalyzer with wavelength dispersive spectrometers / J Electron Microscopy / 50 / 77 / 82 / 2001 / Online Journal

Watanabe,I., Woldou,M., Watanabe,K., and Okabe,T. / Effect of casting method on castability of titanium and dental alloys / J Mater Sci: Mater in Med / 11 / 547 / 553 / 2000 / Online Journal

Watanabe,K., Okawa,S., Kanatani,M., Nakano,S., Miyakawa,O., and Kobayashi,M. / New Partition Technique for Two-chamber Pressure Casting Unit for Titanium / Dent Mater J / 19 / 307 / 316 / 2000 / Online Journal

Akhter,R., Okawa,S., Nakano,S., Kobayashi,M., and Miyakawa,O. / Surface Composition and Structure of Titanium Polished with Aqueous Slurry of Ferric Oxide / Dent Mater J / 19 / 10 / 21 / 2000 / Online Journal

Baltag,I., Watanabe,K., Kusakari,H., Taguchi,N., Miyakawa,O., Kobayashi,M., and Ito,N. / Long-term Changes of Hydroxyapatite-Coated Dental Implants / J Biomed Mater Res.(Appl Biomater) / 53 / 76 / 85 / 2000 / Online Journal






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