Academic Organization

Microbiology and Infectious Diseases

http://www.dent.niigata-u.ac.jp/microbio/microbio.html




- ・ Bioimaging analysis of host-pathogen interactions
- → Applied research of a novel immune system as a infection control candidate
- → Construction of chimera-immunoglobulins against broad-range of bacteria
- ・ Nanoscale and structural analyses of microbial DNA
- → Development of novel DNA-based adjuvants by using a nano technology
- → Development of molecular-targeting DNA-based antibiotics
- ・ Molecular analyses and characterizations of pathogenic streptococci (Streptococcus mutans/ S. pyogenes/ S. pneumoniae)
- → Investigation of anti-streptococcal biofilms
- ・ Molecular analysis of pneumococcal virulence factors in the severity pneumonia
- ・ Investigation of osteoimmunology in periodontal disease




Yutaka TERAOProfessorDepartment of Oral Microbiology, Faculty of Dentistry
Hisanori DOMONAssistant ProfessorDepartment of Oral Microbiology, Faculty of Dentistry







Nagai K, Domon H, Oda M, Shirai T, Ohsumi T, Terao Y, Arai Y. / Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria. / Dent Mater J. / in press. / / / 2017 /

Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H. / Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers. / Arch Oral Biol. / 81 / 110 / 120 / 2017 /

Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G. / Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis. / J Dent Res. / 96 / 571 / 577 / 2017 /

Domon H, Oda M, Maekawa T, Nagai K, Takeda W, Terao Y. / Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis. / Sci Rep. / 6 / 38013 / / 2016 /

Takenaka S, Oda M, Domon H, Ohsumi T, Suzuki Y, Ohshima H, Yamamoto H, Terao Y, Noiri Y. / Vizantin inhibits bacterial adhesion without affecting bacterial growth and causes Streptococcus mutans biofilm to detach by altering its internal architecture. / Biochem Biophys Res Commun. / 480 / 173 / 179 / 2016 /

Yamamoto H, Oda M, Kanno M, Tamashiro S, Tamura I, Yoneda T, Yamasaki N, Domon H, Nakano M, Takahashi H, Terao Y, Kasai Y, Imagawa H. / Chemical hybridization of Vizantin and Lipid A to generate a novel LPS antagonist. / Chem Pham Bull. / 64 / 246 / 257 / 2016 /

Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y. / Anti-biofilm and bactericidal effects of Magnolia bark-derived magnolol and honokiol on Streptococcus mutans. / Microbiol Immunol. / 60 / 10 / 16 / 2016 /

Kurosawa M, Oda M, Domon H, Saitoh I, Hayasaki H, Terao Y. / Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells. / Microb Infect. / 18 / 118 / 127 / 2016 /

Domon H, Uehara Y, Oda M, Seo H, Kubota N, Terao Y. / Poor survival of Methicillin-resistant Staphylococcus aureus on inanimate objects in the public spaces. / MicrobiologyOpen. / 5 / 39 / 46 / 2016 /

Oda M, Terao Y, Sakurai J, Nagahama M. / Membrane-binding mechanism of Clostridium perfringens alpha-toxin. / Toxins / 7 / 5268 / 5275 / 2015 /

Namba K, Takeuchi K, Kaihara Y, Oda M, Nakayama A, Nakayama A, Yoshida M, Tanino K. / Total synthesis of palau'amin. / Nat Commun. / 6 / 8731 / / 2015 /

Miyamoto K, Seike S, Takagishi T, Okui K, Oda M, Takehara M, Nagahama M. / Identification of the replication region in pBCNF5603, a bacteriocin-encoding plasmid, in the enterotoxigenic Clostridium perfringens strain F5603. / BMC Microbial. / 15 / 118 / / 2015 /

Kubo M, Nishikawa Y, Harada K, Oda M, Huang JM, Domon H, Terao Y, Fukuyama Y. / Tetranorsesquiterpenoids and santalane-type sesquiterpenoids from Illicium lanceolatum and their antimicrobial activity against the oral pathogen Porphyromonas gingivalis. / J Nat Prod. / 78 / 1466 / 1469 / 2015 /

Yamada H, Nakajima T, Domon H, Honda T, Yamazaki K. / Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice. / J. Periodontal Res. / 50 / 500 / 508 / 2015 /

Takagishi, T., Oda, M., Kabura, M., Kurosawa, M., Tominaga, K., Urano, S., Ueda, Y.,Kobayashi, K., Kobayashi, T., Sakurai, J., Terao, Y., and Nagahama, M. / Clostridium perfringens alpha-toxin induces GM1a clustering and TrkA phosphorylation in the host cell membrane. / PLoS one / 10 / e0120497 / / 2015 /

Nagahama M., Ochi S., Oda M., Miyamoto K., Takehara M., and Kobayashi K. / Recent insights into Clostridium perfringens beta-toxin. / Toxins / 7 / 396 / 406 / 2015 /

Ohsumi, T., Takenaka, S., Wakamatsu, R., Sakaue, Y., Narisawa, N., Senpuku, H., Ohshima, H., Terao, Y., and Okiji, T. / Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development. / PLoS one / 10 / e0116647 / / 2015 /

Oda, M., Yamamoto, H., Shibutani, M., Nakano, M., Yabiku, K., Tarui, T., Kameyama, N., Shirakawa, D., Obayashi, S., Watanabe, N., Nakase, H., Suenaga, M., Matsunaga, Y., Nagahama, M., Takahashi, H., Imagawa, H., Kurosawa, M., Terao, Y., Nishizawa, M., and / Vizantin inhibits endotoxin-mediated immune responses via the Toll-like receptor 4/MD-2 complex. / J. Immunol. / 193 / 4507 / 4514 / 2014 /

Domon, H., Nakajima, T., Tabeta, K., and Yamazaki, K. / Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis. / J. Periodontal Res. / 49 / 536 / 543 / 2014 /

Oda, M., Imagawa, H., Kato, R., Yabiku, K., Yoshikawa, T., Takemoto, T., Takahashi, H., Yamamoto, H., Nishizawa, M., Sakurai, J., Nagahama, M. / Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis. / J. Enz. Inhib. Med. Chem. / 29 / 303 / 310 / 2014 /

Aoki-Nonaka, Y., Nakajima, T., Miyauchi, S., Miyazawa, H., Yamada, H., Domon, H., Tabeta, K., Yamazaki, K. / Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis. / J. Periodontal Res. / 49 / 536 / 543 / 2014 /

Wakamatsu, R., Takenaka, S., Ohsumi, T., Terao, Y., Ohshima, H., Okiji, T. / Penetration kinetics of four mouthrinses into Streptococcus mutans biofilms analyzed by direct time-lapse visualization. / Clin. Oral Investig. / 18 / 625 / 634 / 2014 /

Nohara, F., Nagaya, K., Asai, H., Tsuchida, E., Okamoto, T., Hayashi, T., Sakata, H., Terao, Y., and Azuma, H. / Neonatal pleural empyema caused by emm type 6 group A Streptococcus. / Pediatirics International / 55 / 519 / 521 / 2013 /

Chakraborty, S., Rendon-Ramirez, A., Asgeirsson, B., Dutta, M., Ghosh, A., Oda, M., Venkatramani, R., Rao, B., Dandekar, A., Goni, F. / Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. / F1000Research / 2 / 286 / / 2013 /

Murakami, T., Saitoh, I., Inada, E., Kurosawa, M., Iwase, Y., Noguchi, H., Terao, Y., Yamasaki, Y., Hayasaki, H., and Sato, M. / STO feeder cells are useful for propagation of primarily cultured human deciduous dental pulp cells in view of elimination of contaminated bacteria and promotion of cellular outgrowth. / Cell Medicine / 6 / 75 / 81 / 2013 /

Yamaguchi, M., Terao, Y., Mori-Yamaguchi, M., Domon, H., Sakaue, Y., Yagi, T., Nishino, K., Yamaguchi, A., Nizet, V., and Kawabata, S. / Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. / PLoS one / 8 / e77282 / / 2013 /

Nagahama, M., Shibutani, M., Seike, S., Yonezaki, M., Takagishi, T., Oda, M., Kobayashi, K., Sakurai, J. / The p38 MAPK and JNK pathways protect host cells against Clostridium perfringens beta-toxin. / Infect. Immun. / 81 / 3703 / 3708 / 2013 /

Ramirez, A.R., Shukla, M., Oda, M., Chakraborty, S., Minda, R., Asgeirsson, B., Goni, FM., Rao, BJ. / Computational module assembled from different protease family motifs identifiesPI PLC from Bacillus cereus as a putative prolyl peptidase having a serine protease scaffold. / PLoS one / 8 / e70923 / / 2013 /

Nagahama, M., Oda, M., Kobayashi, K., Ochi, S., Takagishi, T., Shibutani, M., Sakurai, J. / A recombinant carboxy-terminal domain of alpha-toxin protects mice against Clostridium perfringens. / Microbiol. Immunol. / 57 / 340 / 345 / 2013 /

Yamamoto, H., Oda, M., Nakano, M., Watanabe, N., Yabiku, K., Shibutani, M., Nakanishi, T., Suenaga, M., Inoue, M., Imagawa, H., Nagahama, M., Matsunaga, Y., Himeno, S., Setsu, K., Sakurai, J., Nishizawa, M. / Concise Synthesis of a Probe Molecule Enabling Analysis and Imaging of Vizantin. / Chem. Pharm. Bull. / 61 / 452 / 459 / 2013 /

Tsurumura, T., Tsumori, Y., Qiu, H., Oda, M., Sakurai, J., Nagahama, M., Tsuge, H. / Arginine ADP-ribosylation Mechanism Based on Structural Snapshots of Iota-toxin and Actin Complex. / Proc. Natl. Acad. Sci. U S A. / 110 / 4267 / 4272 / 2013 /

Oda, M., Fujita, A., Okui, K., Miyamoto, K., Shibutani, M., Takagishi, T., Kobayashi, K., Nagahama, M. / Bacillus cereus sphingomyelinase recognizes ganglioside GM3. / Biochem. Biophys. Res. Commun. / 431 / 164 / 168 / 2013 /

Yamamoto, H., Oda, M., Nakano, M., Watanabe, N., Yabiku, K., Shibutani, M., Inoue, M., Imagawa, H., Nagahama, M., Himeno, S., Setsu, K., Sakurai, J., Nishizawa, M. / Development of Vizantin, a safe immunostimulant, based on the structure-activity relationship of Treharose-6,6'-Dicorynomycolate. / J. Med. Chem. / 56 / 381 / 385 / 2013 /

Fatmawati, N.N.D., Sakaguchi, Y., Suzuki, T., Oda, M., Shimizu, K., Yamamoto, Y., Sakurai, J., Matsushita, O., Oguma, K. / Phospholipase C produced by Clostridium botulinum types C and D: comparison of gene, enzymatic, and biological activities with those of Clostridium perfringens alpha-toxin. / Acta Med. Okayama / 67 / 9 / 18 / 2013 /

Yamaguchi M., Terao Y., and Kawabata S. / Pleiotropic virulence factor - Streptococcus pyogenes fibronectin-binding proteins. / Cell. Microbiol / 15 / 503 / 511 / 2013 /

Honda-Ogawa, M., Ogawa, T., Terao, Y., Sumitomo, T., Nakata, N., Ikebe, K., Maeda, Y., and Kawabata, S. / Cysteine proteinase from Streptococcus pyogenes enables to evade innate immunity via degradation of complement factors. / J. Biol. Chem / 288 / 15854 / 15864 / 2013 /

Sumitomo, T., Nakata, M., Higashino, M., Terao, Y., and Kawabata, S. / Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation. / J. Biol. Chem / 288 / 13317 / 13324 / 2013 /

Okahashi, N., Nakata, M., Sumitomo, T., Terao, Y., and Kawabata, S. / Hydrogen peroxide produced by oral streptococci induces macrophage cell death. / PLoS one / 8 / e62563 / / 2013 /

Ogawa T., Terao Y., Honda-Ogawa M., Hashimoto S., Ikebe K., Maeda Y., and Kawabata S. / MicroRNA fragments derived from Streptococcus pyogenes enable activation of neutrophil phagocytosis: in vitro study. / Microb. Infect. / 15 / 212 / 218 / 2013 /

Murakami, J., Terao, Y., Morisaki, I., Hamada, S., and Kawabata, S / Group A streptococcus adheres to pharyngeal epithelial cells with salivary proline-rich proteins via GrpE chaperone protein. / J. Biol. Chem. / 287 / 22266 / 22275 / 2012 /

Mori, Y., Yamaguchi, M., Terao, Y., Hamada, S., Ooshima, T., and Kawabata, S. / α-enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular traps. / J. Biol. Chem. / 287 / 10472 / 10481 / 2012 /

Ogawa, T., Yamasaki, S., Honda, M., Terao, Y., Kawabata, S., and Maeda, Y. / Long-term survival of salivary streptococci on dental devices made of EVA. / Int. J. Oral Science / 4 / 14 / 18 / 2012 /

Kimura, K. R., Nakata, M., Sumitomo, T., Kreikemeyer, B., Podbielski, A., Terao, Y., and Kawabata, S. / Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes. / J. Bacteriol. / 194 / 804 / 812 / 2012 /

Sumitomo, T., Nakata, M., Yamaguchi, M., Terao, Y., and Kawabata S. / S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. / J. Med. Microbiol. / 61 / 101 / 108 / 2012 /

Nakata, M., Kimura, K. R., Sumitomo, T., Wada, S., Sugauchi, A., Oki, E., Higashino, M., Kreikemeyer, B., Podbielski, A., Okahashi, N., Hamada, S., Isoda, R., Terao, Y., and Kawabata, S. / Assembly Mechanism of FCT Type 1 Pili in Serotype M6 Streptococcus pyogenes. / J. Biol. Chem. / 286 / 37566 / 37577 / 2011 /

Okahashi, N., Okinaga T., Sakurai, A., Terao Y., Nakata M. Nakashima K., Shintani S., Kawabata S., Ooshima T., and Nishihara T. / Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species. / FEMS Microbiol. Lett. / 323 / 164 / 170 / 2011 /

Hoshino, T., Kondo, Y., Saito, K., Terao, Y., Okahashi, N., Kawabata, S., and Fujiwara, T. / Novel Epitopic Region of Glucosyltransferase B from Streptococcus mutans. / Clin. Vaccine Immunol. / 18 / 1552 / 1561 / 2011 /

Baatarjav, T, Kataoka, K, Gilbert, R. S, Terao, Y, Fukui, M, Goto, M, Kawabata, S, Yamamoto, M, Fujihashi, K, and Ito, HO / Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination. / Vaccine / 79 / 2819 / 2828 / 2011 /

Ogawa, T., Terao, Y., Okuni, H., Ninomiya, K., Sakata, H., Ikebe, K., Maeda, Y., and Kawabata, S. / Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis. / Microb. Pathog. / 51 / 58 / 68 / 2011 /

Ogawa, T., Terao, Y., Sakata, H., Okuni, H., Ninomiya, K., Ikebe, K., Maeda, Y., and Kawabata, S. / Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. / FEMS Microbiol. Lett. / 318 / 143 / 151 / 2011 /

Kataoka,K., Fujihashi, K., Terao, Y., Gilbert, R. S., Sekine, S., Kobayashi, R., Fukuyama, Y., Kawabata, S., and Fujihashi, K. / Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cells. / PLoS one / 6 / e25396 / / 2011 /

16. Okahashi, N., Nakata, M., Sakurai, A., Terao, Y., Hoshino, T., Yamaguchi, Y., Isoda, R., Sumitomo, T., Nakano, K., Kawabata, S., and Ooshima, T. / Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. / Microb. Pathog. / 50 / 148 / 154 / 2011 /

Sumitomo, T., Nakata, M., Higashino, M., Jin Y., Terao, Y., Fujinaga, Y., and Kawabata, S. / Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. / J. Biol. Chem. / 286 / 2750 / 2761 / 2011 /

Nakagaki, H., Sekine, S., Terao, Y., Toe, M., Tanaka, M., Shizukuishi, S., Ito, H., Kawabata, S., McGhee, JR., Fujihashi, K., and Kataoka, K. / Fusobacterium nucleatum envelope protein, FomA, is immunogenic and binds to salivary statherin-derived peptide. / Infect. Immun. / 78 / 1185 / 1192 / 2010 /

Okahashi, N., Nakata, M., Sakurai, A., Terao, Y., Hoshino, T., Yamaguchi, Y., Isoda, R., Sumitomo, T., Nakano, K., Kawabata, S., and Ooshima, T / Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. / Biochem. Biophys. Res. Commun. / 391 / 1192 / 1196 / 2010 /

Yamaguchi, M., Minamide, M., Terao, Y., Isoda, R., Ogawa, T., Yokota, S., Hamada, S. and Kawabata, S. / Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. / Biochem. Biophys. Res. Commun. / 390 / 155 / 160 / 2009 /

Terao, Y., Isoda, R., Murakami, J. Hamada, S. and Kawabata, S. / Molecular and biological characterization of novel gtf regulation-associated genes in Streptococcus mutans. / Oral Microbiol. Immunol. / 24 / 211 / 217 / 2009 /

Nakata, M., K_ller, T. , Moritz, K., Ribardo, D., Jonas, L., McIver, K. S., Sumitomo, T., Terao, Y., Kawabata, S., Podbielski, A. and Kreikemeyer, B. / Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. / Infect. Immun. / 77 / 32 / 44 / 2009 /

Yamaguchi, M., Terao, Y., Hamada, S. and Kawabata, S. / PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis. / J. Biol. Chem. / 283 / 36272 / 36279 / 2008 /

Okamoto, S., Terao, Y., Hasuike, K., Hamada, S. and Kawabata, S. / A novel streptococcal leucine zipper protein (Lzp) that binds to binds to human immunoglobulins. / Biochem. Biophys. Res. Commun. / 377 / 1128 / 1134 / 2008 /

Terao, Y., Mori, Y., Yamaguchi, M., Shimizu, Y., Ooe, K., Hamada, S. and Kawabata S. / Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. / J. Biol. Chem. / 283 / 6253 / 6260 / 2008 /

Kunitomo, E., Terao, Y., Okamoto, S., Rikimaru, T., Hamada, S. and Kawabata, S. / Molecular and biological characterization of histidine triad protein in group A streptococci. / Microbes Infect. / 10 / 414 / 423 / 2008 /

Okamoto, S., Terao, Y., Tamura, Y., Hamada, S. and Kawabata, S. / Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes. / FEMS Microbiol. Lett. / 281 / 73 / 80 / 2008 /

IItsuki ,Y., Saeki, M., Nakahara, H., Egusa, H., Irie, Y., Terao, Y., Kawabata, S., Yatani, H. and Kamisaki, H. / Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. / FEBS Lett. / 582 / 2365 / 2370 / 2008 /

Saeki, M., Irie, Y. Ni, L. Itsuki, Y. Terao, Y., Kawabata, S. and Kamisaki Y. / Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation. / J. Biol. Chem. / 282 / 11786 / 11794 / 2007 /

Okamaoto, S., Terao, Y., Kaminishi, H., Hamada, S. and Kawabata S. / Induction of immune responses by streptococcal water-insoluble alpha-glucans. / J. Dent. Res. / 86 / 242 / 248 / 2007 /

Yamaguchi, M., Terao, Y., Ogawa, T., Takahashi, T., Hamada, S. and Kawabata S. / Role of Streptococcus sanguinis sortase A in bacterial colonization. / Microb. Infect. / 8 / 2791 / 2796 / 2006 /

Terao, Y., Yamaguchi, M., Hamada, S. and Kawabata, S. / Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. / J. Biol. Chem. / 281 / 14215 / 14223 / 2006 /

Terao, Y., Okamoto, S., Kataoka, K., Hamada, S. and Kawabata, S. / Protective immunity against Streptococcus pyogenes challenge in mice after immunization with fibronectin-binding protein. / J. Infect. Dis. / 192 / 2081 / 2091 / 2005 /

Yoshida, M., Saeki, M., Itsuki, Y., Irie, Y., Terao, Y., Kawabata, S., Hamada, S., Niwa, H. and Kamisaki, Y. / Search for calcineurin B binding proteins by yeast two-hybrid system. / J. Pharma. Sci. / 97 / 217 / 217 / 2005 /

Okamoto, S., Tamura, Y., Terao, Y., Hamada, S. and Kawabata, S. / Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice. / Vaccine / 23 / 4852 / 4859 / 2005 /

Kaito, C., Kurokawa, K., Matsumoto, M., Terao, Y., Kawabata, S., Hamada, S. and Sekimizu, K. / Silkworm-pathogenic bacteria infection model for identification of novel virulence genes. / Mol. Microbiol. / 56 / 934 / 944 / 2005 /

Okamoto, S., Kawabata, S., Terao, Y., Fujitaka, H., Okuno, Y. and Hamada, S. / Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal invasive bacterial-viral superinfection. / Infect. Immun. / 72 / 6068 / 6075 / 2004 /

Terao, Y., Kawabata, S., Nakata, M., Nakagawa, I. and Hamada, S. / Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes associated with isolates from toxic shock-like syndrome patients. / J. Biol. Chem. / 277 / 47428 / 47435 / 2002 /

Kawabata, S., Tamura, Y., Murakami, J., Terao, Y., Nakagawa, I. and Hamada, S. / A novel, anchorless streptococcal surface protein. / Biochem. Biophys. Research. / 296 / 1329 / 1333 / 2002 /

Murakami, J., Kawabata, S., Terao, Y., Kikuchi, K., Totsuka, K., Tamaru, A., Katsukawa, C., Moriya, K., Nakagawa, I., Morisaki, I. and Hamada, S. / Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan from 1994 to 1999. / Epidemiol. Infect. / 128 / 397 / 404 / 2002 /

Terao, Y., Kawabata, S., Kunitomo, E., Nakagawa, I. and Hamada, S. / A novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in the adhesion to epithelial cells. / Infect. Immun. / 70 / 993 / 997 / 2002 /

Terao, Y., Kawabata, S., Kunitomo, E., Murakami, J., Nakagawa, I. and Hamada, S. / Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. / Mol. Microbiol. / 42 / 75 / 86 / 2001 /

Kawabata, S., Kunitomo, E., Terao, Y., Nakagawa, I., Kikuchi, K., Totsuka, K. and Hamada, S. / Systemic and mucosal immunization with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge. / Infect Immun. / 69 / 924 / 930 / 2001 /

Kawabata, S., Terao, Y., Nakagawa, I. and Hamada, S. / Molecular cloning, sequence, and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene. / Oral Microbiol. Immunol. / 15 / 56 / 62 / 2000 /

Kawabata, S., Terao, Y., Fujiwara, T., Nakagawa, I. and Hamada, S. / Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G and serum immunoglobulin G antibodies in mice. / Infect. Immun. / 67 / 5863 / 5868 / 1999 /

Fujiwara, T., Terao, Y., Hoshino, T., Kawabata, S., Ooshima, T., Sobue, S., Kimura, S. and Hamada, S. / Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans. / FEMS Microbiol. Lett. / 161 / 331 / 336 / 1998 /

Kawabata, S., Terao, Y., Andoh, A. and Hamada, S. / Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii. / FEMS Microbiol. Lett. / 156 / 211 / 216 / 1997 /

Terao, Y., Kawabata, S., Kunitomo, E., Naklagawa, I. and Hamada, S. / Immunization of mice with streptococcal fibronectin binding protein. / Streptococci and Streptococcal Diseases: Entering the new Millennium, Securacopy / / 451 / 453 / 2000 /

Kawabata, S., Murakami, J., Terao, Y., Naklagawa, I. and Hamada, S. / Distribution of Streptococcus pyogenes superantigens is associated with clinical status. / Streptococci and Streptococcal Diseases: Entering the new Millennium, Securacopy / / 175 / 178 / 2000 /

Minami, T., Fujiwara, T., Terao, Y., Kawabata, S., Ooshima, T. and Hamada, S. / In vitro recombination of sucrose-dependent cellular adherence of Streptococcus mutans. / Streptococci and Streptococcal Diseases: Entering the new Millennium, Securacopy / / 915 / 917 / 2000 /

Terao Y / The virulence factors and pathogenic mechanisms on Streptococcus pyogenes. / J. Oral Bioscience / 54 / 96 / 100 / 2012 /

Terao Y / Possible mechanisms related to development of severe Streptococcus pyogenes infections. / J. Oral Bioscience / 50 / 89 / 97 / 2008 /

Oda, M., Imagawa, H., Kato, R., Yabiku, K., Yoshikawa, T., Takemoto, T., Takahashi, H., Yamamoto, H., Nishizawa, M., Sakurai, J., Nagahama, M. / Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis. / J. Enz. Inhib. Med. Chem. / 54 / 231 / 131 / 2013 /

Nagahama, M., Oda, M., Kobayashi, K., Ochi, S., Takagishi, T., Shibutani, M., Sakurai, J. / A recombinant carboxy-terminal domain of alpha-toxin protects mice against Clostridium perfringens. / Microbiol. Immunol. / 57 / 340 / 345 / 2013 /

Yamamoto, H., Oda, M., Nakano, M., Watanabe, N., Yabiku, K., Shibutani, M., Nakanishi, T., Suenaga, M., Inoue, M., Imagawa, H., Nagahama, M., Matsunaga, Y., Himeno, S., Setsu, K., Sakurai, J., Nishizawa, M. / Concise Synthesis of a Probe Molecule Enabling Analysis and Imaging of Vizantin. / Chem. Pharm. Bull. / 61 / 452 / 459 / 2013 /

Tsurumura, T., Tsumori, Y., Qiu, H., Oda, M., Sakurai, J., Nagahama, M., Tsuge, H. / Arginine ADP-ribosylation Mechanism Based on Structural Snapshots of Iota-toxin and Actin Complex. / Proc. Natl. Acad. Sci. U S A. / 110 / 4267 / 4372 / 2013 /

Oda, M., Fujita, A., Okui, K., Miyamoto, K., Shibutani, M., Takagishi, T., Kobayashi, K., Nagahama, M. / Bacillus cereus sphingomyelinase recognizes ganglioside GM3. / Biochem. Biophys. Res. Commun. / 431 / 164 / 168 / 2013 /

Yamamoto, H., Oda, M., Nakano, M., Watanabe, N., Yabiku, K., Shibutani, M., Inoue, M., Imagawa, H., Nagahama, M., Himeno, S., Setsu, K., Sakurai, J., Nishizawa, M. / Development of Vizantin, a safe immunostimulant, based on the structure-activity relationship of Treharose-6,6'-Dicorynomycolate. / J. Med. Chem. / 56 / 381 / 385 / 2013 /

Fatmawati, N.N.D., Sakaguchi, Y., Suzuki, T., Oda, M., Shimizu, K., Yamamoto, Y., Sakurai, J., Matsushita, O., Oguma, K.: / Phospholipase C produced by Clostridium botulinum types C and D: comparison of gene, enzymatic, and biological activities with those of Clostridium perfringens alpha-toxin. / Acta Med. Okayama / 67 / 9 / 18 / 2013 /

Oda, M., Kabura, M., Takagishi, T., Suzue, A., Tominaga, K., Urano, S., Nagahama, M., Kobayashi, K., Furukawa, K., Furukawa, K., Sakurai, J. / Oda, M., Kabura, M., Takagishi, T., Suzue, A., Tominaga, K., Urano, S., Nagahama, M., Kobayashi, K., Furukawa, K., Furukawa, K., Sakurai, J. / J. Biol. Chem. / 287 / 33070 / 33079 / 2012 /

Oda, M., Shiihara, R., Ohmae, Y., Kabura, M., Takagishi, T, Kobayashi, K., Nagahama, M., Inoue, M., Abe, T., Setsu, K., Sakurai, J. / Clostridium perfringens alpha-toxin induces the release of IL-8 through a dual pathway via TrkA in A549 cells. / Biophys. Biochim. Acta - Molecular Basis of Disease / 1822 / 1581 / 1589 / 2012 /

Oda, M., Hashimoto, M., Takahashi, M., Ohmae, Y., Seike, S., Kato, R., Fujita, A., Tsuge, H., Nagahama, M., Ochi, S., Sasahara, T., Hayashi, S., Hirai, Y., Sakurai, J. / Role of Sphingomyelinase in Infectious Diseases Caused by Bacillus cereus. / PLoS one / 7 / e38054 / / 2012 /

Oda, M., Takahashi, M., Tsuge, H., Nagahama, M., Sakurai, J. / Role of side-edge site of sphingomyelinase from Bacillus cereus. / Biochem. Biophys. Res. Commun. / 422 / 128 / 132 / 2012 /

Nagahama, M., Umezaki, M., Tashiro, R., Oda, M., Kobayashi, K., Shibutani, M., Takagishi, T., Ishidoh, K., Fukuda, M., Sakurai, J. / Intracellular trafficking of Clostridium perfringens iota-toxin b. / Infect. Immun. / 80 / 3410 / 3416 / 2012 /

Imagawa, H., Saijo, H., Yamaguchi, H., Maekawa, K., Kurisaki, T., Yamamoto, H., Nishizawa, M., Oda, M., Kabura, M., Nagahama, M., Sakurai, J., Kubo, M., Nakai, M., Makino, K., Ogata, M., Takahashi, H., Fukuyama, Y. / Syntheses of Structurally-simplified and Fluorescently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 cells. / Bioorg. Med. Chem. Lett. / 22 / 2089 / 2093 / 2012 /

Inubushi, T., Kamemura, N., Oda, M., Sakurai, J., Nakaya, Y., Harada, N., Suenaga, M., Matsunaga, Y., Ishidoh, K., Katunuma, N. / L-tryptophan suppresses rise in blood glucose and preserves insulin secretion in type-2 diabetes mellitus rats. / J. Nutr. Sci. Vitaminol. / 58 / 415 / 422 / 2012 /

Nagahama, M., Umezaki, M., Oda, M., Kobayashi, K., Tone, S., Suda, T., Ishidoh, K., Sakurai, J. / Clostridium perfringens iota-b induces rapid cell necrosis. / Infect. Immun. / 79 / 4353 / 4360 / 2011 /

Nagahama, M., Itohayashi, Y., Hara, H., Higashihara, M., Fukatani, Y., Takagishi, T., Oda, M., Kobayashi, K., Nakagawa, I., Sakurai, J. / Cellular vacuolation induced by Clostridium perfringens epsilon-toxin. / FEBS J. / 278 / 3395 / 3407 / 2011 /

Oda, M., Saito, Y., Morimune, Y., Nagahama, M., Sakurai, J. / Induction of neurite-outgrowth in PC12 cells by alpha-toxin from Clostridium perfringens. / Biochem. Biophys. Res. Commun. / 411 / 241 / 246 / 2011 /

Nagahama M., Ohkubo, A., Oda, M., Kobayashi, K., Amimoto, K., Miyamoto, K., Sakurai, J. / Clostridium perfringens TpeL glycosylates the Rac and Ras subfamily proteins. / Infect. Immun. / 79 / 905 / 910 / 2011 /

Imagawa, H., Oda, M., Takemoto, T., Yamauchi, R., Yoshikawa, T., Yamamoto, H., Nishizawa, M., Takahashi, H., Hashimoto, M., Yabiku, K., Nagahama, M., Sakurai, J. / Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors. / Bioorg. Med. Chem. Lett. / 20 / 3868 / 3871 / 2010 /

Oda, M., Takahashi, M., Matsuno, T., Uoo, K., Nagahama, M., Sakurai, J. / Hemolysis induced byBacillus cereus sphingomyelinase. / Biophys. Biochim. Acta - Biomembranes / 1798 / 1073 / 1080 / 2010 /

Ishidoh, K., Kamemura, N., Imagawa, T., Oda, M., Sakurai, J., Katunuma, N. / Quinolinate phosphoribosyl transferase, a key enzyme in de novo NAD+ synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3. / Biophys. Biochim. Acta - Molecular Cell Research / 1803 / 527 / 533 / 2010 /

Nagahama, M., Hagiyama, T., Kojima, T., Aoyanagi, K., Takahashi, C., Oda, M., Sakaguchi, Y., Oguma, K., Sakurai, J. / Binding and internalization of Clostridium botulinum C2 toxin. / Infect. Immun. / 77 / 5139 / 5148 / 2009 /

Tumurkhuu, G., Koide, N., Dagvadorj, J., Noman, A., Khuda, I., Naiki, Y., Komatsu, T., Yoshida, T., Oda, M., Nagahama, M., Sakurai, J., Yokochi, T. / The inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation. / Int. J. Med. Microbiol. / 299 / 554 / 564 / 2009 /

Oda M, Kihara A, Yoshioka H, Saito Y, Watanabe N, Uoo K, Higashihara M, Nagahama M, Koide N, Yokochi T, Sakurai J. / Effect of erythromycin on biological activities induced by Clostridium perfringensalpha-toxin. / J. Pharmacol. Exp. Ther. / 327 / 934 / 940 / 2008 /

Tsuge, H. , Nagahama, M., Oda, M., Iwamoto, S., Utsunomiya, H., Marquez, V. E., Katunuma, N., Nishizawa, M., Sakurai, J. / Structural basis of actin recognition and arginine ADP-ribosylation byClostridium perfringens iota-toxin. / Proc. Natl. Acad. Sci. U S A. / 105 / 7399 / 7404 / 2008 /

Oda, M., Matsuno, T., Shiihara, R., Ochi, S., Yamauchi, R., Imagawa, H., Nagahama, M., Nishizawa, M., Sakurai, J. / The relationship between the metabolism of sphingomyelin species and hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin. / J. Lipid Res. / 49 / 1039 / 1047 / 2008 /

Nagahama, M., Kihara, A., Kintoh, H., Oda, M., Sakurai, J. / Involvement of tumor necrosis factor-a inClostridium perfringens beta-toxin-induced plasma extravasation in mice. / Br. J. Pharmacol. / 153 / 1296 / 1302 / 2008 /

Kobayashi, K., Nagahama , M., Ohkubo, N., Kojima, T., Shirai, H., Iwamoto, S., Oda, M., Sakurai, J. / Role of Ca2+-binding motif in cytotoxity induced by Clostridium perfringens iota-toxin. / Microb. Pathog. / 44 / 265 / 270 / 2008 /

Nagahama, M., Otsuka, A., Oda, M., Singh, R., Zyta, Z., Imagawa, H., Nishizawa, M., Sakurai, J. / Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane damaging action ofClostridium perfringens alpha-toxin toward liposomes. / Biochim. Biophys. Acta-Biomembranes / 1768 / 2940 / 2945 / 2007 /

Ago, H., Oda, M., Takahashi, M., Tsuge, H., Ochi, S., Katsunuma, N., Miyano, M., Sakurai, J. / Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. / J. Biol. Chem. / 281 / 16157 / 16167 / 2006 /

Oda, M., Ikari, S., Matsuno, T., Morimune, Y., Nagahama, M., Sakurai, J. / The signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils. / Infect. Immun. / 74 / 2876 / 2886 / 2006 /

Zhai, H., Nakade, K., Oda, M., Mitsumoto, Y., Akagi, M., Sakurai, J., Fukuyama, Y. / Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinase (ERK1/2). / Eur. J. Pharmacol. / 516 / 112 / 117 / 2005 /

Ochi, S., Oda, M., Matsuda, H., Ikari, S., Sakurai, J. / Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythromycin. / J. Biol. Chem. / 279 / 12181 / 12189 / 2004 /

Ochi, S., Oda, M., Nagahama, M., Sakurai, J. / Clostridium perfringens alpha-toxin induced hemolysis of horse erythrocytes is dependent on Ca2+ uptake. / Biochim. Biophys. Acta - Biomembranes / 1613 / 79 / 86 / 2003 /

Ochi, S., Miyawaki, T., Matsuda, H., Oda, M., Nagahama, M., Sakurai, J. / Clostridium perfringens alpha-toxin induces rabbit neutrophil adhension. / Microbiology (UK) / 148 / 237 / 245 / 2002 /

Aoki-Nonaka, Y., Nakajima, T., Miyauchi, S., Miyazawa, H., Yamada, H., Domon, H., Tabeta, K., Yamazaki, K. / Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis. / J. Periodontal Res. / 49 / 69 / 76 / 2014 /

Miyazawa, H., Tabeta, K., Miyauchi, S., Aoki-Nonaka, Y., Domon, H., Honda, T., Nakajima, T., Yamazaki, K. / Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice. / Lipids Health Dis. / 11 / 121 / / 2012 /

Miyazawa, H., Honda, T., Miyauchi, S., Domon, H., Okui, T., Nakajima, T., Tabeta, K., Yamazaki, K. / Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration. / Clin. Chim. Acta, / 413 / 154 / 159 / 2012 /

Liang, S., Krauss, J.L., Domon, H., McIntosh, M. L., Hosur, K.B., Qu, H., Li, F., Tzekou, A., Lambris, J.D., Hajishengallis, G. / The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. / J. Immunol. / 186 / 869 / 877 / 2011 /

Takahashi, N., Honda, T., Domon, H., Nakajima, T., Tabeta, K., Yamazaki, K. / Interleukin-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. / J. Periodontal Res. / 45 / 512 / 519 / 2011 /

Nakajima, T., Honda, T., Domon, H., Okui, T., Kajita, K., Ito, H., Takahashi, N., Maekawa, T., Tabeta, K., Yamazaki, K. / Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. / J. Periodontal Res. / 45 / 116 / 122 / 2010 /

Liang, S., Hosur, K.B., Domon, H., Hajishengallis, G. / Periodontal inflammation and bone loss in aged mice. / J. Periodontal Res. / 45 / 574 / 578 / 2010 /

Wang, M., Krauss, J.L., Domon, H., Hosur, K.B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J.D., Hajishengallis G. / Microbial hijacking of complement-toll-like receptor crosstalk. / Sci. Signal. / 3 / ra11 / / 2010 /

Wang, M., Liang, S., Hosur, K.B., Domon, H., Yoshimura, F., Amano, A., Hajishengallis, G. / Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis. / Oral Microbiol. Immunol. / 24 / 478 / 484 / 2009 /

Liang, S., Domon, H., Hosur, K.B., Wang, M., Hajishengallis, G. / Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. / Mech. Ageing Dev. / 130 / 538 / 546 / 2009 /

Domon, H., Takahashi, N., Honda, T., Nakajima, T., Tabeta, K., Abiko, Y., Yamazaki, K. / Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. / Clin. Chim. Acta / 401 / 134 / 140 / 2009 /

Honda, T., Aoki, Y., Takahashi, N., Maekawa, T., Nakajima, T., Ito, H., Tabeta, K., Okui, T., Kajita, K., Domon, H., Yamazaki, K. / Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. / Clin. Chim. Acta / 395 / 137 / 141 / 2008 /

Domon, H., Honda, T., Oda, T., Yoshie, H., Yamazaki, K. / Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis. / J. Leukoc. Biol. / 83 / 672 / 679 / 2008 /

Kajita, K., Honda, T., Amanuma, R., Domon, H., Okui, T., Ito, H., Yoshie, H., Tabeta, K., Nakajima, T., Yamazaki, K. / Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis. / Oral Microbiol. Immunol. / 22 / 398 / 402 / 2007 /

Yamazaki, K., Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., Kudoh, C., Takashiba, S., Kokeguchi, S., Nishimura, F., Kodama, M., Aizawa, Y., Oda, H. / Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. / Clin. Exp. Immunol. / 149 / 445 / 452 / 2007 /

Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., Yamazaki, K. / Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. / Clin. Exp. Immunol. / 144 / 35 / 40 / 2006 /

Ito, H., Honda, T., Domon, H., Oda, T., Okui, T., Amanuma, R., Nakajima, T., Yamazaki, K. / Gene expression analysis of the CD4+ T-cell clones derived from gingival tissues of periodontitis patients. / Oral Microbiol. Immunol. / 20 / 382 / 386 / 2005 /






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