Academic Organization

Anatomy and Cell Biology of the Hard Tissue

http://www.dent.niigata-u.ac.jp/anatomy1/




- Development and regeneration of dentin/pulp complex
- Epithelial mesenchymal interaction during tooth development
- The mechanism of tooth morphogenesis using gene-knock out mice
- The immune defense mechanism of dental pulp
- The role of extracellular matrix molecules during tooth development
- The mechanism of enamel organ morphogenesis
- Cell biology of biomineralization in hard tissue
- Cytochemistry and molecular biology of hard tissue formation and resorption
- Histochemical and molecular biological studies on regulation of bone metabolism
- Healing process of the bone-implant interface following placement of dental implants using mouse experimental models
- Macroscopic anatomical study on risk factors for complications during dental implant surgery in humans
- Carbohydrate metabolism during tooth development
- Macroscopic anatomical study on facial muscles and the surrounding tissues in human




Hayato OHSHIMAProfessorFirst Department of Oral Anatomy, Faculty of Dentistry
Hiroko IDA-YONEMOCHIAssociate ProfessorFirst Department of Oral Anatomy, Faculty of Dentistry
Kotaro SAITOAssistant ProfessorFirst Department of Oral Anatomy, Faculty of Dentistry
Mikako TANAKAResearch FellowFirst Department of Oral Anatomy, Faculty of Dentistry
Taisuke WATANABEResearch StudentFirst Department of Oral Anatomy, Faculty of Dentistry
Eri USHIMURAGraduate StudentFirst Department of Oral Anatomy, Faculty of Dentistry
Yuta SEINOGraduate StudentFirst Department of Oral Anatomy, Faculty of Dentistry
Sanako MAKISHIGraduate StudentFirst Department of Oral Anatomy, Faculty of Dentistry
Shin-ichi KENMOTSULab TechnicianFirst Department of Oral Anatomy, Faculty of Dentistry
Megumi SUGAISecretaryFirst Department of Oral Anatomy, Faculty of Dentistry





Ohshima H / Dental and Oral Biology, Anatomy / / Reference Module in Biomedical Sciences / / Academic Press / Massachusetts / 2014 /

Ohshima, H., Maeda, T., Maas, R. and Satokata, I. / Functional significance of Msx2 gene during tooth development. / Ishikawa, T., Takahashi, K., Maeda, T., Suda, H., Shimono, M. and Inoue, T. / Dentin/Pulp Complex, Proceeding of the International Conference on Dentin/Pulp Complex 2001 / / Quintessence Publishing Co. Ltd. / Tokyo / 2002 / 11 / 14 /

Ohshima, H. and Nakakura-Ohshima, K. / Functional significance of heat shock protein (Hsp) 25 during pulpal regeneration after cavity preparation and tooth replantation in rat molars. / / Proceeding, Program and Abstract of the 7th International Seminar for JSPS-NRCT Core University Program / / / / 2002 / 1 / 5 /

Honda MJ, Ohshima H / Stem cells in tooth development and regeneration / Singh SR / Stem cell, regenerative medicine and cancer / / Nova Science Publishers / Hauppauge NY / 2010 / 185 / 206 /



Ohshima H / Oral biosciences: The annual review 2016 / J Oral Biosci / 59 / 1 / 5 / 2017 / Online Journal

Saito K, Ohshima H / Differentiation capacity and maintenance of dental pulp stem/progenitor cells in the process of pulpal healing following tooth injuries / J Oral Biosci / 59 / 63 / 70 / 2017 / Online Journal

Sugawara S, Shigetani Y, Kenmotsu S, Okiji T, Ohshima H / Evaluation of a new mouse model for studying dental pulpal responses to GaAlAs laser irradiation / J Oral Biosci / 59 / 38 / 43 / 2017 / Online Journal

Makishi S, Saito K, Ohshima H / Osteopontin-deficiency disturbs direct osteogenesis in the process of achieving osseointegration following immediate placement of endosseous implants / Clin Implant Dent Relat Res / in press / / / 2016 / Online Journal

Ida-Yonemochi H, Yamada Y, Yoshikawa H, Seo K / Locally produced BDNF promotes sclerotic change in alveolar bone after nerve injury / PLoS One / 12 / e0169201 / / 2017 / Online Journal

Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H / Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers / Arch Oral Biol / in press / / / 2017 / Online Journal

Iwamoto T, Nakamura T, Ishikawa M, Yoshizaki K, Sugimoto A, Ida-Yonemochi H, Ohshima H, Saito M, Yamada Y, Fukumoto S / Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities / PLoS One / 12 / e0177557 / / 2017 / Online Journal

Ishikawa Y, Nakatomi M, Ida-Yonemochi H, Ohshima H / Quiescent adult stem cells in murine teeth are regulated by Shh signaling / Cell Tissue Res / in press / / / 2017 / Online Journal

Ohkura M, Ohkura N, Yoshiba N, Yoshiba K, Ida-Yonemochi H, Ohshima H, Saito I, Okiji T / Orthodontic force application upregulated pain-associated prostaglandin-I2/PGI2-receptor/TRPV1 pathway-related gene expression in rat molars / Odontology / in press / / / 2017 /

Seino Y, Takano Y, Ohshima H / The positional and ultrastructural changes in peripheral pulp capillaries correlate with the active phase of dentin deposit and mineralization in rat molars / J Oral Biosci / in press / / / 2017 /

Goto N, Fujimoto K, Fujii S, Ida-Yonemochi H, Ohshima H, Kawamoto T, Noshiro M, Shukunami C, Kozai K, Kato Y / Role of MSX1 in osteogenic differentiation of human dental pulp cells / Stem Cells Int / / 8035759 / / 2016 / Online Journal

Saitoh I, Sato M, Soda M, Inada E, Iwase Y, Murakami T, Ohshima H, Hayasaki H, Noguchi H / Tissue-specific stem cells obtained by reprogramming of non-obese diabetic (NOD) mouse-derived pancreatic cells confer insulin production in response to glucose / PLoS One / 11 / e0163580 / / 2016 / Online Journal

Takenaka S, Oda M, Domon H, Ohsumi T, Suzuki Y, Ohshima H, Yamamoto H, Terao Y, Noiri Y / Vizantin inhibits bacterial adhesion without affecting bacterial growth and causes Streptococcus mutans biofilm to detach by altering its internal architecture / Biochem Biophys Res Commun / 480 / 173 / 179 / 2016 / Online Journal

Li L, Tang Q, Nakamura T, Suh JG, Ohshima H, Jung HS / Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry / Sci Rep / 6 / 37828 / / 2016 / Online Journal

Otsu K, Ida-Yonemochi H, Fujiwara N, Harada H / The semaphorin 4D-RhoA-Akt signal cascade regulates enamel matrix secretion in coordination with cell polarization during ameloblast differentiation / J Bone Miner Res / 31 / 1943 / 1954 / 2016 / Online Journal

Ohshima H / Oral biosciences: The annual review 2015 / J Oral Biosci / 58 / 1 / 10 / 2016 / Online Journal

Nakatomi C, Nakatomi M, Saito K, Harada H, Ohshima H / Enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors / Arch Oral Biol / 60 / 1122 / 1130 / 2015 / Online Journal

Katsumi Y, Takagi R, Ohshima H / The occurrence rate and diameter of arteries traveling near the mandible and assessment of relative hemorrhage risk in implant surgery / Clin Implant Dent Relat Res / 18 / 1023 / 1033 / 2016 / Online Journal

Ida-Yonemochi H, Otsu K, Ohshima H, Harada H / The glycogen metabolism via Akt signalling is important for the secretion of enamel matrix in tooth development / Mech Dev / 139 / 18 / 30 / 2016 / Online Journal

Shigetani Y, Ohkura N, Yoshiba K, Ohshima H, Hosoya A, Yoshiba N, Okiji T / GaAlAs laser-induced pulp mineralization involves dentin matrix protein 1 and osteopontin expression / Oral Dis / 22 / 399 / 405 / 2016 / Online Journal

Saito K, Nakatomi M, Ida-Yonemochi H, Ohshima H / Osteopontin is essential for type I collagen secretion in reparative dentin / J Dent Res / 95 / 1034 / 1041 / 2016 / Online Journal

Kasahara N, Tanaka R, Hayashi T, Kenmotsu S, Ohshima H / The relationship of the maxillary sinus with the superior alveolar nerves and vessels as demonstrated by cone-beam CT combined with m-CT and histological analyses / Anat Rec (Hoboken) / 299 / 669 / 678 / 2016 / Online Journal

Morita W, Morimoto N, Ohshima H / Exploring metameric variation in human molars: a morphological study using morphometric mapping / J Anat / 229 / 343 / 355 / 2016 / Online Journal

Ohshima H / Oral Biosciences: The annual review 2014 / J Oral Biosci / 57 / 1 / 8 / 2015 / Online Journal

Shigetani Y, Yoshiba K, Takei E, Yoshiba N, Yamanaka Y, Ohshima H, Okiji T / Temporospatial localisation of dentine matrix protein 1 following direct pulp capping with calcium hydroxide in rat molars / Int Endod J / 48 / 573 / 581 / 2015 / Online Journal

Nakaki T, Saito K, Ida-Yonemochi H, Nakagawa E, Kenmotsu S, Ohshima H / Contribution of Donor and Host Mesenchyme to the Transplanted Tooth Germs / J Dent Res / 94 / 112 / 120 / 2015 / Online Journal

Watanabe T, Nakagawa E, Saito K, Ohshima H / Differences in healing patterns of the bone-implant interface between immediately and delayed placed titanium implants into the mouse maxilla / Clin Implant Dent Relat Res / 18 / 146 / 160 / 2016 / Online Journal

Ohsumi T, Takenaka S, Wakamatsu R, Sakaue Y, Ohshima H, Terao Y, Okiji T / Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development / PLoS One / 10 / e0116647 / / 2015 / Online Journal

Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H / The effects of enzymatically synthesized glycogen on the pulpal healing process of teeth with intentionally delayed replantation in mice / J Oral Biosci / 57 / 124 / 130 / 2015 / Online Journal

Saito K, Ida-Yonemochi H, Ushiki T, Ohshima H / Responses of pulp vasculature to cavity preparation in rat molars / J Oral Biosci / 57 / 157 / 164 / 2015 / Online Journal

Ohshima H / Oral Biosciences: The annual review 2013 / J Oral Biosci / 56 / 1 / 10 / 2014 / Online Journal

Saito K, Kenmotsu S, Nakatomi M, Ohshima H / Allogenic tooth transplantation inhibits the maintenance of dental pulp stem/progenitor cells in mice / Cell Tissue Res / 356 / 357 / 367 / 2014 / Online Journal

Ida-Yonemochi H, Nakatomi M, Ohshima H / Establishment of in vitro culture system for evaluating dentin-pulp complex regeneration with special reference to the differentiation capacity of BrdU label-retaining dental pulp cells / Histochem Cell Biol / 142 / 323 / 333 / 2014 / Online Journal

Maruyama S, Itagaki M, Ida-Yonemochi H, Kubota T, Yamazaki M, Abe T, Yoshie H, Cheng J, Saku T / Perlecan-enriched intercellular space of junctional epithelium provides primary infrastructure for leucocyte migration through squamous epithelial cells / Histochem Cell Biol / 142 / 297 / 305 / 2014 / Online Journal

Morita W, Yano W, Nagaoka T, Abe M, Nakatsukasa M / Size and shape variability in human molars during odontogenesis / J Dent Res / 93 / 275 / 280 / 2014 / Online Journal

Morita W, Yano W, Nagaoka T, Abe M, Ohshima H, Nakatsukasa M / Patterns of morphological variation in enamel-dentin junction and outer-enamel surface of human molars / J Anat / 224 / 669 / 680 / 2014 / Online Journal

Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H / Effects of a triple antibiotic solution on pulpal dynamics following intentionally delayed tooth replantation in mice / J. Endod / 40 / 1566 / 1572 / 2014 / Online Journal

Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H / Use of a triple antibiotic solution affects the healing process of intentionally delayed replanted teeth in mice / J Oral Biosci / 55 / 91 / 100 / 2013 / Online Journal

Nakatomi M, Hovorakova M, Gritli-Linde A, Blair H, MacArthur K, Peterka M, Lesot H, Peterkova R, Ruiz-Perez VL, Goodship J, Peters H / Evc regulates a symmetric response to Shh signaling in molar development / J Dent Res / 92 / 222 / 228 / 2013 / Online Journal

Ohshima H / Oral Biosciences: The annual review 2012 / J Oral Biosci / 55 / 1 / 5 / 2013 / Online Journal

Ida-Yonemochi H / Role of perlecan, a basement membrane-type heparan sulfate proteoglycan, in enamel organ morphogenesis / J Oral Biosci / 55 / 23 / 28 / 2013 / Online Journal

Nakatomi M, Hovorakova M, Gritli-Linde A, Blair H, MacArthur K, Peterka M, Lesot H, Peterkova R, Ruiz-Perez VL, Goodship J, Peters H / Evc regulates a symmetric response to Shh signaling in molar development / J Dent Res / 92 / 222 / 228 / 2013 / Online Journal

Nakatomi M, Ida-Yonemochi H, Ohshima H / Lymphoid enhancer-binding factor 1 expression precedes dentin sialophosphoprotein expression during rat odontoblast differentiation and regeneration / J Endod / 39 / 612 / 618 / 2013 / Online Journal

Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H / Use of a triple antibiotic solution affects the healing process of intentionally delayed replanted teeth in mice / J Oral Biosci / 55 / 91 / 100 / 2013 / Online Journal

Yamashita-Mikami E, Tanaka M, Sakurai N, Yamada K, Ohshima H, Nomura S, Ejiri S / Microstructural observation with microCT and histological analysis of human alveolar bone biopsy from a planned implant site: A case trial. / Open Dent J / 7 / 47 / 54 / 2013 / Online Journal

Ida-Yonemochi H, Harada H, Ohshima H, Saku T / Reciprocal expressions between α-dystroglycan and integrin β1, perlecan receptors, in the murine enamel organ development / Gene Expr Patterns / 13 / 293 / 302 / 2013 / Online Journal

Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Mishima Y, Sakuraba Y, Gondo Y, Takagi R, Ohshima H, Kominami R / Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors / Mech Dev / 130 / 482 / 492 / 2013 / Online Journal

Wakamatsu R, Takenaka S, Ohsumi T, Terao Y, Ohshima H, Okiji T / Penetration kinetics of four mouthrinses into Streptococcus mutans biofilms analyzed by direct time-lapse visualization / Clin Oral Investig / 18 / 625 / 634 / 2013 / Online Journal

Saito K, Nakatomi M, Ohshima H / Dynamics of BrdU label-retaining dental pulp cells during pulpal healing following cavity preparation in mice / J Endod / 39 / 1250 / 1255 / 2013 / Online Journal

Takenaka S, Ohshima H, Ohsumi T, Okiji T / Current and future strategies for the control of mature oral biofilms — Shift from a bacteria-targeting to a matrix-targeting approach / J Oral Biosci / 54 / 173 / 179 / 2012 / Online Journal

Shigetani Y, Suzuki H, Ohshima H, Yoshiba K, Yoshiba N, Okiji T / Odontoblast response to cavity preparation with Er:YAG laser in rat molars: an immunohistochemical study / Odontology / 101 / 186 / 192 / 2013 / Online Journal

Katsumi Y, Tanaka R, Hayashi T, Koga T, Takagi R, Ohshima H / Variation in arterial supply to the floor of the mouth and assessment of relative hemorrhage risk in implant surgery / Clin Oral Implants Res / 24 / 434 / 440 / 2013 / Online Journal

Yamashita-Mikami E, Tanaka M, Sakurai N, Arai Y, Matsuo A, Ohshima H, Nomura S, Ejiri S / Correlations between alveolar bone microstructure and bone turnover markers in pre- and post-menopausal women / Oral Surg Oral Med Oral Pathol Oral Radiol Endod / 115 / e12 / 119 / 2012 / Online Journal

Ali MN, Kobayashi T, Tanaka M, Ohshima H, Ejiri S, Saito C / Effects of intermittent parathyroid hormone treatment on new bone formation during distraction osteogenesis in the rat mandible / Oral Surg Oral Med Oral Pathol Oral Radiol Endod / 114 / e36 / e42 / 2012 / Online Journal

Sato T, Kenmotsu S, Nakakura-Ohshima K, Takahashi N, Ohshima H / Pulpal responses to antimicrobials in the infected dental pulp of rat molars / Arch Histol Cytol / 73 / 165 / 175 / 2010 / Online Journal

Quispe-Salcedo A, Ida-Yonemochi H, Nakatomi M, Ohshima H / Expression patterns of nestin and dentin sialoprotein in the process of dentinogenesis in mice / Biomed Res / 33 / 119 / 132 / 2012 / Online Journal

Ishikawa Y, Ida-Yonemochi H, Nakakura-Ohshima K, Ohshima H / The relationship between cell proliferation and differentiation and mapping of putative dental pulp stem cells during mouse molar development by chasing BrdU-labeling / Cell Tissue Res / 348 / 95 / 107 / 2012 / Online Journal

Ida-Yonemochi H, Maruyama S, Kobayashi T, Yamazaki M, Cheng J, Saku T / Loss of keratin 13 in oral carcinoma in-situ: a comparative study of protein and gene expression levels using paraffin sections / Modern Pathology / 25 / 784 / 794 / 2012 / Online Journal

Nakagawa E, Zhang Li, Shin JO, Kim EJ, Cho SW, Ohshima H, Chen Z, Jung HS / The novel expression of Oct3/4 and Bmi1 in the root development of mouse molars / Cell Tissue Res / 347 / 479 / 484 / 2012 / Online Journal

Ida-Yonemochi H, Nakatomi M, Harada H, Takata H, Baba O, Ohshima H / Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars / Dev Biol / 363 / 52 / 61 / 2012 / Online Journal

Nakagawa E, Zhang Li, Kim EJ, Shin JO, Cho SW, Ohshima H, Jung HS / The novel function of Oct3/4 in mouse tooth development / Histochem Cell Biol / 137 / 367 / 376 / 2012 / Online Journal

Ohshima H / Oral Biosciences: The annual review 2011 / J Oral Biosci / 54 / 1 / 4 / 2012 / Online Journal

Mutoh N, Nakatomi M, Ida-Yonemochi H, Nakagawa E, Tani-Ishii N, Ohshima H / Responses of BrdU label-retaining dental pulp cells to allogenic tooth transplantation into mouse maxilla / Histochem Cell Biol / 136 / 649 / 661 / 2011 / Online Journal

Ida-Yonemochi H, Satokata I, Ohshima H, Sato T, Yokoyama M, Yamada Y, Saku T / Morphogenetic roles of perlecan in the tooth enamel organ: an analysis of overexpression using transgenic mice / Matrix Biol / 30 / 379 / 388 / 2011 / Online Journal

Cai J, Mutoh N, Shin JO, Tani-Ishii N, Ohshima H, Cho SW, Jung HS / Wnt5a plays a crucial role in determining tooth size during murine tooth development / Cell Tissue Res / 345 / 367 / 377 / 2011 / Online Journal

Ida-Yonemochi H, Shahidul A, Saku T / Differential expression profiles between α-dystroglycan and integrin β1 in ameloblastoma: two possible perlecan signaling pathways for cellular growth and differentiation / Histopathology / 58 / 234 / 245 / 2011 / Online Journal

Saito K, Ishikawa Y, Nakakura-Ohshima K, Ida-Yonemochi H, Nakatomi M, Kenmotsu S, Ohshima H / Differentiation capacity of BrdU label-retaining dental pulp cells during pulpal healing following allogenic transplantation in mice / Biomed Res / 32 / 247 / 257 / 2011 / Online Journal

Tanaka R, Hayashi T, Ohshima H, Ida-Yonemochi H, Kenmotsu S, Ike M / CT anatomy of the anterior superior alveolar nerve canal: a macro and microscopic study / Oral Radiol / 27 / 93 / 97 / 2011 / Online Journal

Shigetani Y, Sasa N, Suzuki H, Okiji T, Ohshima H / GaAlAs laser irradiation induces active tertiary dentin formation following pulpal apoptosis and cell proliferation in rat molars / J Endod / 37 / 1086 / 1091 / 2011 / Online Journal

Saito K, Nakatomi M, Ida-Yonemochi H, Kenmotsu S, Ohshima H / The expression of GM-CSF and osteopontin in immunocompetent cells precedes the odontoblast differentiation following allogenic tooth transplantation in mice / J Histochem Cytochem / 59 / 518 / 529 / 2011 / Online Journal

Tanaka M, Yamashita E, Anwar RB, Yamada K, Ohshima H, Nomura S, Ejiri S / Radiological and histological studies of the mandibular cortex of ovariectomized monkeys / Oral Surg Oral Med Oral Pathol Oral Radiol Endod / 111 / 372 / 380 / 2011 / Online Journal

Alvarado CG, Maruyama S, Cheng J, Ida-Yonemochi H, Kobayashi T, Yamazaki M, Takagi R, Saku T / Nuclear translocation of β-catenin synchronized with loss of E-cadherin in oral epithelial dysplasia with a characteristic two-phase appearance / Histopathology / 59 / 283 / 291 / 2011 / Online Journal

Ahsan S, Yamazaki M, Maruyama S, Kobayashi T, Ida-Yonemochi H, Hasegawa M, Cheng J, Saku T / Differential expression of perlecan receptors, α-dystroglycan and integrin β1, before and after invasion of oral squamous cell carcinoma / J Oral Pathol Med / 40 / 552 / 559 / 2011 / Online Journal

Ohzeki K, Yokota R, Ohshima H / Developmental pattern of human milk teeth / Int J Oral-Medical Sci / 9 / 75 / 87 / 2010 / Online Journal

Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS / Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor / Gene Expr Patterns / 11 / 163 / 170 / 2010 / Online Journal

Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubüser A / Regulation of Tbx22 during facial and palatal development / Dev Dyn / 239 / 2860 / 2874 / 2010 / Online Journal

Handajani J, Haniastuti T, Ohshima H, Hoshino E / Survival of root canal pulp tissue after pulpitis / J LSTR Therapy / 9 / 1 / 6 / 2010 / Online Journal

Ida-Yonemochi H, Tanabe Y, Ono Y, Murata M, Saku T / Focal osteoporotic bone marrow defects associated with a cystic change of the maxilla: a possible histopathogenetic background of simple bone cyst / Oral Med Pathol / 15 / 35 / 38 / 2010 / Online Journal

Ida-Yonemochi H, Nakajima M, Saku T / Heparanase, heparan sulfate and perlecan distribution along with the vascular penetration during stellate reticulum retraction in the mouse enamel organ / Arch Oral Biol / 55 / 778 / 787 / 2010 / Online Journal

Ishikawa Y, Ida-Yonemochi H, Suzuki H, Nakakura-Ohshima K, Jung HS, HondaMJ, Ishii Y, Watanabe N, Ohshima H / Mapping of BrdU label-retaining cells in growing teeth and their regenerative capacity after injuries / Histochem Cell Biol / 134 / 227 / 241 / 2010 / Online Journal

Ida-Yonemochi H, Shahidul A, Saku T / Differential expression profiles between α-dystroglycan and integrin β1 in ameloblastoma: two possible perlecan signaling pathways for cellular growth and differentiation / Histopathology / 58 / 234 / 245 / 2010 / Online Journal

Kobayashi T, Maruyama S, Cheng J, Ida-Yonemochi H, Yagi M, Takagi R, Saku T / Histopathological varieties of oral carcinoma in-situ: its diagnosis aided by the immunohistochemistry for the concept of the second basal cell layer as the proliferating center of oral mucosal epithelia / Pathol Int / 60 / 156 / 166 / 2010 / Online Journal

Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A, Chen Y, Maas RL, Peters H / Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis / Dev Biol / 340 / 438 / 449 / 2010 / Online Journal

Unno H, Suzuki H, Nakakura-Ohshima K, Jung HS, Ohshima H / Pulpal regeneration following allogenic tooth transplantation into mouse maxilla / Anat Rec (Hoboken) / 292 / 570 / 579 / 2009 / Online Journal

Cho KW, Cai J, HY, Hosoya A, Ohshima H, Choi KY, Jung HS / ERK activation is involved in tooth development via FGF10 signaling / J Exp Zoolog B Mol Dev Evol / 312 / 901 / 911 / 2009 / Online Journal

Ali MN, Ejiri S, Kobayashi T, Anwar RB, Oda K, Ohshima H, Saito C / Histologic study of the cellular events during rat mandibular distraction osteogenesis / Oral Surg Oral Med Oral Pathol Oral Radiol Endod / 107 / 325 / 335 / 2009 / Online Journal

Ando Y, Honda MJ, Ohshima H, Tonomura A, Ohara T, Itaya T, Kagami H, Ueda M / The induction of dentin bridge-like structures by constructs of subcultured dental pulp-derived cells and porous HA/TCP in porcine teeth / Nagoya J Med Sci / 71 / 51 / 62 / 2009 / Online Journal

Cai J, Cho SW, Ishiyama M, Mikami M, Hosoya A, Kozawa Y, Ohshima H, Jung HS / Chick tooth induction revisited / J Exp Zoolog B Mol Dev Evol / 312B / 465 / 472 / 2009 / Online Journal

Nakatomi M / Ellis-van Creveld (EvC) syndrome: unusual oral defects in humans and Evc mutant mice / J Oral Biosci / 51 / 151 / 157 / 2009 / Online Journal

Swelam WM, Cheng J, Ida-Yonemochi H, Maruyama S, Saku T / Oral solitary fibrous tumor: a cytogenetic analysis of tumor cells in culture with literature review / Cancer Genet Cytogenet / 194 / 75 / 81 / 2009 / Online Journal

Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Mikami T, Alvarado CG, Shahidul AM, Maruyama S, Cheng J, Saku T / Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers / J Oral Pathol Med / 38 / 348 / 355 / 2009 / Online Journal

Ohshima H / Overview: developmental biology of Hertwig's epithelial root sheath (HERS) and tooth root formation / J Oral Biosci / 50 / 147 / 153 / 2008 / Online Journal

Takamori Y, Suzuki H, Nakakura-Ohshima K, Cai J, Cho SW, Jung HS, Ohshima H / Capacity of dental pulp differentiation in mouse molars as demonstrated by allogenic tooth transplantation / J Histochem Cytochem / 56 / 1075 / 1086 / 2008 / Online Journal

Harada M, Kenmotsu S, Nakasone N, Nakakura-Ohshima K, Ohshima H / Cell dynamics in the pulpal healing process following cavity preparation in rat molars / Histochem Cell Biol / 130 / 773 / 783 / 2008 / Online Journal

Kuratate M, Yoshiba K, Shigetani Y, Yoshiba N, Ohshima H, Okiji T / Immunohistochemical analysis of nestin, osteopontin, and proliferating cells in the reparative process of exposed dental pulp capped with mineral trioxide aggregate / J Endod / 34 / 970 / 974 / 2008 / Online Journal

Tsuneki M, Cheng J, Maruyama S, Ida-Yonemochi H, Nakajima M, Saku T / Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor / J Oral Pathol Med / 37 / 287 / 293 / 2008 / Online Journal

Tsuneki M, Cheng J, Yamazaki M, Maruyama S, Kobayashi T, Ida-Yonemochi H, Suzuki M, Saku T / Lateral periodontal cyst: a clinicopathological study of 23 cases and an immunohistochemical analysis of its characteristic epithelial plaques in the lining / Oral Med Pathol / 12 / 89 / 96 / 2008 / Online Journal

Suzuki H, Amizuka N, Oda K, Noda M, Ohshima H, Maeda T / Histological and elemental analyses of impaired bone mineralization in klotho- deficient mice / J Anat / 212 / 183 / 190 / 2008 / Online Journal

Suzuki H, Amizuka N, Oda K, Noda M, Ohshima H, Maeda T / Involvement of the klotho protein in dentin formation and mineralization / Anat Rec (Hoboken) / 291 / 183 / 190 / 2008 / Online Journal

Takahashi N, Ejiri S, Yanagisawa S, Ozawa H / Regulation of osteoclast polarization / Odontology / 95 / 1 / 9 / 2007 / Online Journal

Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H / Rat wct mutation induces a hypo-mineralization form of amelogenesis imperfecta and cyst formation in molar teeth / Cell Tissue Res / 330 / 97 / 109 / 2007 / Online Journal

Osawa M, Kenmotsu S, Masuyama T, Taniguchi K, Uchida T, Saito C, Ohshima H / Rat wct mutation prevents differentiation of maturation-stage ameloblasts resulting in hypo-mineralization in incisor teeth / Histochem Cell Biol / 128 / 189 / 193 / 2007 / Online Journal

Hasegawa T, Suzuki H, Yoshie H, Ohshima H / Influence of extended operation time and of occlusal force on determination of pulpal healing pattern in replanted mouse molars / Cell Tissue Res / 329 / 259 / 272 / 2007 / Online Journal

Cho SW, Lee HA, Cai J, Lee MJ, Ohshima H, Jung HS / The primary enamel knot determines the position of the first buccal cusp in developing mice molars. / Differentiation / 75 / 441 / 451 / 2007 / Online Journal

Cho KW, Cho SW, Oh CO, Ryu YK, Ohshima H, Jung HS / The effect of cortical activation on orthodontic tooth movement. / Oral Diseases / 13 / 314 / 319 / 2007 / Online Journal

Rezwana BA, Tanaka M, Kohno S, Ikegame M, Watanabe N, Ali MN, Ejiri S / Relationship between changes of alveolar bone and spinal osteoporosis. / J Dent Res / 86 / 52 / 57 / 2007 / Online Journal

Kim JY, Cha YG, Cho SW, Kim EJ, Lee MJ, Lee JM, Cai J, Ohshima H, Jung HS / Inhibition of apoptosis alters tooth shape and size: implications for macrodontia. / J Dent Res / 85 / 530 / 535 / 2006 / Online Journal

Kim E, Cho SW, Yang JY, Cai JL, Lee SJ, Ohshima H, Jung HS / Tooth survival and periodontal tissues healing of allo-transplanted teeth in the mice. / Oral Diseases / 12 / 395 / 401 / 2006 / Online Journal

Nakasone N, Yoshie H, Ohshima H / The relationship between the termination of cell proliferation and expression of heat-shock protein-25 in the rat developing tooth germ. / Eur J Oral Sci 114(4): 302-309, 2006. / 114 / 302 / 309 / 2006 / Online Journal

Kawagishi E, Nakakura-Ohshima K, Nomura S, Ohshima H / Pulpal responses to cavity preparation in aged rat molars. / Cell Tissue Res / 326 / 111 / 122 / 2006 / Online Journal

Ogawa R, Saito C, Jung HS, Ohshima H / Capacity of dental pulp differentiation after tooth transplantation. / Cell Tissue Res / 326 / 715 / 724 / 2006 / Online Journal

Ejiri S, Toyooka E, Tanaka M, Anwar RB, Kohno S / Histological and histomorphometrical changes in rat alveolar bone following antagonistic tooth extraction and/or ovariectomy. / Arch Oral Biol / 51 / 941 / 950 / 2006 / Online Journal

Suzuki H, Amizuka N, Noda M, Amano O, Maeda T / Histological and immunohistochemical changes in the submandibular gland in klotho-deficient mice. / Arch Histol Cytol / 69 / 119 / 128 / 2006 / Online Journal

Tsukamoto-Tanaka H, Ikegame M, Takagi R, Harada H, Ohshima H / Histochemical and immunocytochemical study on hard tissue formation in dental pulp during the healing process after tooth replantation in rat molars. / Cell Tissue Res / 325 / 219 / 229 / 2006 / Online Journal

Nakasone N, Yoshie H, Ohshima H / An immunohistochemical study of the expression of heat-shock protein-25 and cell proliferation in the dental pulp and enamel organ during odontogenesis in rat molars. / Arch Oral Biol / 51 / 378 / 386 / 2006 / Online Journal

Kajiya H, Ito M, Ohshima H, Kenmotsu S, Ries W, Benjamin I, Reddy S / RANK ligand expression in Heat shock factor-2 deficient mouse marrow stromal/preosteoblast cells. / J Cell Biochem / 97 / 1362 / 1369 / 2006 / Online Journal

Yokohama-Tamaki T, Ohshima H, Fujiwara N, Takada Y, Ichimori Y, Wakisaka S, Ohuchi H, Harada H / Cessation of Fgf-10 signaling leads to the transition from crown to root formation due to a defective dental epithelial stem cell compartment. / Development / 133 / 1359 / 1366 / 2006 / Online Journal

Stegaroiu R, Watanabe N, Tanaka M, Ejiri S, Nomura S, Miyakawa O / Peri-implant stress analysis in simulation models with or without trabecular bone structure. / Int J Prosthodont / 19 / 40 / 42 / 2006 / Online Journal

Harada H, Ichimori Y, Yokohama-Tamaki T, Ohshima H, Kawano S, Katsube K, Wakisaka S / Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling. / Biochem Biophys Res Commun / 340 / 611 / 616 / 2006 / Online Journal

Tate Y, Yoshiba K, Yoshiba N, Iwaku M, Okiji T, Ohshima H / Odontoblast responses to GaAlAs laser irradiation in rat molars: an experimental study using heat-shock protein-25-immunohistochemistry. / Eur J Oral Sci / 114 / 50 / 57 / 2006 / Online Journal

Ohshima H / Cell dynamics in the process of pulpal healing following tooth injuries. / J Hard Tissue Biol / 14 / 174 / 175 / 2005 / Online Journal

Suzuki H, Amizuka N, Oda K, Li M, Yoshie H, Ohshima H, Noda M, Maeda T / Histological evidences on altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. / Arch Histol Cytol / 68 / 371 / 381 / 2005 / Online Journal

Kawase T, Okuda K, Saito, Y, Amizuka N, Suzuki H, Yoshie H / Platelet-rich plasma (PRP) provides nucleus for mineralization in cultures of partially differentiated periodontal ligament cells. / In Vitro Cell Dev Biol Animal / 41 / 171 / 176 / 2005 / Online Journal

Okuda K, Tai H, Tanabe K, Suzuki H, Sato T, Kawase T, Saito Y, Wolff LF, Yoshie H / Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: a comparative controlled clinical study. / J Periodontol / 76 / 890 / 898 / 2005 / Online Journal

Masuyama T, Miyajima K, Ohshima H, Osawa M, Yokoi N, Oikawa T, Taniguchi K / A novel autosomal recessive mutation whitish chalk-like teeth (wct) resembling amelogenesis imperfecta maps to rat chromosome 14 corresponding to human 4q21. / Eur J Oral Sci / 113 / 451 / 456 / 2005 / Online Journal

Ohshima H, Nakasone N, Hashimoto E, Sakai H, Nakakura-Ohshima K, Harada H / The eternal tooth germ is formed at the apical end of continuously growing teeth. / Arch Oral Biol / 50 / 153 / 157 / 2005 / Online Journal

Ikegame M, Ejiri S, Ozawa H / Calcitonin-induced change in serum calcium levels and its relationship to osteoclast morphology and number of calcitonin receptors. / Bone / 35 / 27 / 33 / 2004 / Online Journal

Suzuki H, Amizuka N, Kii I, Kawano Y, Nozawa-Inoue K, Suzuki A, Yoshie H, Kudo A, Maeda T / Immunohistochemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development. / Anat Rec / 281A / 1264 / 1275 / 2004 / Online Journal

Asawa Y, Amizuka N, Hara K, Kobayashi M, Aita M, Li M, Kenmotsu S, Oda K, Akiyama Y, Ozawa H / Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats. / Bone / 35 / 870 / 880 / 2004 / Online Journal

Asawa Y, Aoki K, Ohya K, Ohshima H, Takano Y / Appearance of electron-dense segments: indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones. / J Electron Microsc / 53 / 423 / 433 / 2004 / Online Journal

Tazawa K, Hoshi K, Kawamoto S, Tanaka M, Ejiri S, Ozawa H / Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered. / J Bone Miner Metab / 22 / 524 / 529 / 2004 / Online Journal

Harada, H. and Ohshima, H. / New perspectives on tooth development and dental stem cell niche. / Arch. Histol. Cytol. / 67 / 1 / 11 / 2004 / Online Journal

Suzuki, T., Nomura, S., Maeda, T. and Ohshima, H. / An immunocytochemical study of pulpal responses to cavity preparation by laser ablation in rat molars by using antibodies to heat shock protein (Hsp) 25 and class II MHC antigen. / Cell Tissue Res. / 315 / 311 / 319 / 2004 / Online Journal

Hoshi, K., Ogata, N., Shimoaka, T, Terauchi, Y., Kadowaki, T., Kenmotsu, S., Chung, U-R., Ozawa, H., Nakamura, K. and Kawaguchi, H. / Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage. / J. Bone Miner. Res. / 19 / 214 / 223 / 2004 / Online Journal

Ohshima, H., Kenmotsu, S. and Harada, H. / Use of the term apical bud to refer to the apical end of the continuously growing tooth. / Arch. Comp. Biol. Tooth Enamel / 8 / 45 / 49 / 2003 / Online Journal

Nakakura-Ohshima, K., Watanabe, J., Kenmotsu, S., and Ohshima, H. / Possible role of immunocompetent cells and the expression of heat shock protein-25 in the process of pulpal regeneration after tooth injury in rat molars. / J. Electron Microsc. / 52 / 581 / 591 / 2003 / Online Journal

Shirakura, M., Fujii, N., Ohnishi, H., Taguchi, Y., Ohshima, H., Nomura, S. and Maeda, T. / Tissue response to titanium implantation in the rat maxilla, with special reference to the effects of surface conditions on bone formation. / Clin. Oral Implants Res. / 14 / 687 / 696 / 2003 / Online Journal

Ito, M., Ejiri, S., Jinnai, H., Ikeda, S., Nishida, A., Uesugi, K., Yagi, N., Tanaka, M. and Hayashi, K. / Bone structure and mineralization demonstrated using synchrotron radiation computed tomography (SR-CT) in animal models: Preliminary findings. / J. Bone Miner. Metab. / 21 / 287 / 293 / 2003 / Online Journal

Ito, M., Amizuka, N., Tanaka, S., Funatsu-Ozawa, Y., Kenmotsu, S., Oda, K., Nakajima, T. and Ozawa, H. / Ultrastructural and cytobiological studies on possible interactions between PTHrP-secreting tumor cells, stromal cells, and bone cells. / J. Bone. Miner. Metab. / 21 / 353 / 362 / 2003 / Online Journal

Shimomura, J., Ishibashi, O., Ikegame, M., Yoshizawa, T., Ejiri, S., Noda, T. and Kawashima, H. / Tensile stress induces a-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation. / J. Cell. Physiol. / 195 / 488 / 496 / 2003 / Online Journal

Takano, Y., Sakai, H., Watanabe, E., Ideguchi-Ohma, N., Jayawardena, C.K., Arai, K., Asawa, Y., Nakano, Y., Shuda, Y., Sakamoto, Y. and Terashima T. / Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum. / J. Electron Microsc. / 52 / 573 / 580 / 2003 / Online Journal

Tanaka, M., Toyooka, E., Kohno, S., Ozawa, H. and Ejiri, S. / Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy. / Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. / 95 / 495 / 502 / 2003 / Online Journal

Ohshima, H., Nakakura-Ohshima, K., Takeuchi, K., Hoshino, M., Takano, Y. and Maeda, T. / Pulpal regeneration after cavity preparation, with special reference to close spatio-relationships between odontoblasts and immunocompetent cells. / Microsc. Res. Tech. / 60 / 483 / 490 / 2003 / Online Journal

Tamura, H., Nakakura-Ohshima, K., Maeda, T. and Ohshima, H. / Different distribution of immunocompetent cells in the dentogingival junction during root formation in rat molars. / J. Periodontal Res. / 38 / 10 / 19 / 2003 / Online Journal

Fujii, N., Ohnishi, H., Shirakua, M., Nomura, S., Ohshima, H. and Maeda, T. / Regeneration of nerve fibres in the peri-implant epithelium incident to implantation in the rat maxilla as demonstrated by immunocytochemistry for protein gene product 9.5 (PGP 9.5) and calcitonin gene-related peptide (CGRP). / Clin. Oral Implants Res. / 14 / 240 / 247 / 2003 / Online Journal

Gong, L., Hoshi, K., Ejiri, S., Nakajima, T. and Ozawa, H. / Effects of YM175 on ectopic bones induced by rhBMP-2 in rats. / J. Bone Miner. Metab. / 21 / 5 / 11 / 2003 / Online Journal

Matin, K. Senpuku, H., Ozawa, H. and Ejiri, S. / Bone regeneration by recombinant human bone morphogenetic protein-2 (rhBMP-2) around immediate implants: A pilot study in rats. / Int. J. Oral Maxillofac. Implants / 18 / 39 / 45 / 2003 / Online Journal

Ohshima, H., Nakakura-Ohshima, K. and Maeda, T. / Expression of heat-shock protein 25 immunoreactivity in the dental pulp and enamel organ during odontogenesis in the rat molar. / Connect. Tissue Res. / 43 / 220 / 223 / 2002 / Online Journal

Yamamoto, H., Kawano, Y., Nozawa-Inoue, K., Aita, M., Miki, Y., Sasaki, J. and Maeda, T. / The expression of copper, zinc superoxide dismutase (Cu/Zn-SOD) in the rat submandibular gland. / Biomed. Res. / 23 / 85 / 90 / 2002 / Online Journal

Kawamoto, S., Ejiri, S., Hoshi, K., Nagaoka, E. and Ozawa, H. / Immunolocalization of osteoclast differentiation factor in rat periodontium. / Arch. Oral Biol. / 47 / 55 / 58 / 2002 / Online Journal

Kawamoto, S., Ejiri, S., Hoshi, K., Nagaoka, E. and Ozawa, H. / Effects of estrogen deficiency on osteoclastgenesis in rat periodontium. / Arch. Oral Biol. / 47 / 67 / 73 / 2002 / Online Journal

Tanaka, M., Ejiri, S., Toyooka, E., Kohno, S. and Ozawa, H. / Effects of ovariectomy on trabecular structures of rat alveolar bone. / J. Periodontal Res. / 37 / 161 / 165 / 2002 / Online Journal

Irie, K., Takeishi, H., Truga, E., Sakakura, Y., Ozawa, H., Ejiri, S. and Yajima, T. / Changes of osteopontin distribution and matrix mineralization during remodeling in experimental bone formation. / Acta Histochem. / 35 / 113 / 118 / 2002 / Online Journal

Yoshiba, K., Yoshiba, N., Ejiri, S., Iwaku, M. and Ozawa, H. / Odontblast processes in human dentin revealed by fluorescence labeling and transmission electron microscopy. / Histochem. Cell Biol. / 118 / 205 / 212 / 2002 / Online Journal

Saito, Y., Yoshizawa, T., Takizawa, F., Ikegame, M., Ishibashi, O., Okuda, K., Hara, K., Ishibashi, K., Obinata, M. and Kawashima, H. / A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. / J. Cell Sci. / 115 / 4191 / 4200 / 2002 / Online Journal






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