Academic Organization

Biochemistry






- Brain regulation of appetite

We are examining how appetite is controlled in the hypothalamus.

- Various neuronal receptors are expressed in oral cancer. We are examining the role of these receptors.
- Mechanisms regulating the function of brain is studied.
- Molecular mechanisms regulation saliva secretion is studied.
- PTHrP)has two localization signals. Analysis of the interaction of the signal peptide with the protein conducting channel of the endoplasmic reticulum is performed.




Miho TERUNUMAProfessordepartment of oral biochemistry, faculty of dentistry
Yoshihiro AMAYAAssociate professordepartment of oral biochemistry, faculty of dentistry
Sari KISHIKAWAAssistant Professordepartment of oral biochemistry, faculty of dentistry
Fumiko HARADAAssistant Professor





Miho Terunuma, Menelas N Pangalos, Stephen J. Moss / Functional modulation of GABAB receptors by protein kinases and receptor trafficking. / Thomas Blackburn / GABAb Receptor Pharmacology: A Tribute to Norman Bowery / / Advance in Pharmacology / / 2010 / 113 / 22 /



Allograft inflammatory factor 1 is a regulator of transcytosis in M cells.Nat Commun. / Nat Commun. / 8 / 14509 / / 2017 / https://www.ncbi.nlm.nih.gov/pubmed/28224999 /

Evolutionary well-conserved region in the signal peptide of parathyroid hormone-related protein is critical for its dual localization through the regulation of ER translocation. / J Biochem / 159 / 393 / 406 / 2016 / https://www.ncbi.nlm.nih.gov/pubmed/26538570 /

A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons. / J Neurosci. / 36 / 3106 / 3114 / 2016 / https://www.ncbi.nlm.nih.gov/pubmed/26985023 /

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. / Proc Natl Acad Sci U S A. / 112(48) / 14805 / 14810 / 2015 / https://www.ncbi.nlm.nih.gov/pubmed/26627235 /

Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. / Neuropharmacology. / 88 / 74 / 81 / 2015 / https://www.ncbi.nlm.nih.gov/pubmed/25261019 /

Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. / PLoS One / 9 / e108294 / / 2014 / https://www.ncbi.nlm.nih.gov/pubmed/25244033 /

Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by γ-aminobutyric type B receptors. / J Biol Chem. / 289(42) / 28808 / 28815 / 2014 / https://www.ncbi.nlm.nih.gov/pubmed/25172509 /

Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. / Proc Natl Acad Sci U S A. / 111(19) / 7132 / 7137 / 2014 / https://www.ncbi.nlm.nih.gov/pubmed/24778259 /

Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. / J Neurosci. / 34(3) / 804 / 816 / 2014 / https://www.ncbi.nlm.nih.gov/pubmed/24431439 /

The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. / J Neurosci. / 33(39) / 15567 / 15577 / 2013 / https://www.ncbi.nlm.nih.gov/pubmed/24068823 /

Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. / / / / / 2013 / https://www.ncbi.nlm.nih.gov/pubmed/23616535 /

Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. / Neuron. / 73(5) / 978 / 989 / 2012 / https://www.ncbi.nlm.nih.gov/pubmed/22405207 /

Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans. / Int J Mol Sci. / 13 / 15475 / 15495 / 2012 / https://www.ncbi.nlm.nih.gov/pubmed/23203137 /

Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. / Dev Cell. / 21(4) / 655 / 68 / 2011 / https://www.ncbi.nlm.nih.gov/pubmed/21944720 /

The dynamic modulation of GABA(A) receptor trafficking and its role in regulating the plasticity of inhibitory synapses. / Physiol Rev. / 91(3) / 1009 / 1022 / 2011 / https://www.ncbi.nlm.nih.gov/pubmed/21742794 /

Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a Src kinase dependent pathway. / Glia. / 59(7) / 1084 / 1093 / 2011 / https://www.ncbi.nlm.nih.gov/pubmed/21544869 /

Functional modulation of GABAB receptors by protein kinases and receptor trafficking. / Adv Pharmacol. / 58 / 13 / 122 / 2010 / https://www.ncbi.nlm.nih.gov/pubmed/20655480 /

Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. / Proc Natl Acad Sci U S A. / 107(31) / 13918 / 13923 / 2010 / https://www.ncbi.nlm.nih.gov/pubmed/20643948 /

Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling. / J Neurosci. / 29(50) / 15796 / 15809 / 2009 / https://www.ncbi.nlm.nih.gov/pubmed/20016095 /

Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. / Proc Natl Acad Sci U S A. / 106(47) / 20039 / 2044 / 2009 / https://www.ncbi.nlm.nih.gov/pubmed/19903874 /

Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. / Proc Natl Acad Sci U S A. / 106(35) / 15037 / 15042 / 2009 / https://www.ncbi.nlm.nih.gov/pubmed/19706442 /

The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons. / J Biol Chem. / 283(36) / 24641 / 24648 / 2008 / https://www.ncbi.nlm.nih.gov/pubmed/18579521 /

Cleavage of the ER-targeting signal sequence of parathyroid hormone-related protein is cell-type-specific and regulated in Cis by its nuclear localization signal. / J Biochem / 143 / 569 / 579 / 2008 / https://www.ncbi.nlm.nih.gov/pubmed/18211921 /

Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. / J Neurosci. / 28(2) / 376 / 384 / 2008 / https://www.ncbi.nlm.nih.gov/pubmed/18184780 /

Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. / J Neurosci. / 27951) / 14012 / 14022 / 2007 / https://www.ncbi.nlm.nih.gov/pubmed/18094240 /

mGluR5 stimulates gliotransmission in the nucleus accumbens. / Proc Natl Acad Sci U S A. / 104(6) / 1995 / 2000 / 2007 / https://www.ncbi.nlm.nih.gov/pubmed/17259307 /

Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. / Neuron. / 53(2) / 233 / 247 / 2007 / https://www.ncbi.nlm.nih.gov/pubmed/17224405 /

Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein--implications in the phospho-modulation of the GABAA receptor. / Adv Enzyme Regul. / 46 / 203 / 222 / 2006 / https://www.ncbi.nlm.nih.gov/pubmed/16854455 /

PRIP, a novel Ins(1,4,5)P3 binding protein, functional significance in Ca2+ signaling and extension to neuroscience and beyond. / Mol Cells. / 20(3) / 305 / 314 / 2005 / https://www.ncbi.nlm.nih.gov/pubmed/16404143 /

Direct interaction of N-ethylmaleimide-sensitive factor with GABA(A) receptor beta subunits. / Mol Cell Neurosci. / 30(2) / 197 / 206 / 2005 / https://www.ncbi.nlm.nih.gov/pubmed/16095914 /

Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension. Retarded secretion and proteasomal degradation. / FEBS J. / 272 / 1704 / 1717 / 2005 / https://www.ncbi.nlm.nih.gov/pubmed/15794757 /

GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. / J Neurosci. / 24(32) / 7074 / 7084 / 2004 / https://www.ncbi.nlm.nih.gov/pubmed/15306641 /

Tissue-nonspecific alkaline phosphatase with an Asp(289)-->Val mutation fails to reach the cell surface and undergoes proteasome-mediated degradation. / J Biochem / 134 / 63 / 70 / 2003 / https://www.ncbi.nlm.nih.gov/pubmed/12944372 /

Purification and characterization of multiple forms of rat liver xanthine oxidoreductase expressed in baculovirus-insect cell system. / J Biochem / 132 / 597 / 606 / 2002 / https://www.ncbi.nlm.nih.gov/pubmed/12359075 /

Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha. / J Biol Chem. / 276(21) / 17908 / 17913 / 2001 / https://www.ncbi.nlm.nih.gov/pubmed/11278544 /






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