Academic Organization

Oral Pathology

http://www.dent.niigata-u.ac.jp/patho/patho.html




- Structure and function of basement membrane type heparan sulfate proteoglycan
- Stromal remodeling in the process of proliferation, invasion and metastasis of tumor cells.
- Epidemiologic and molecular pathologic study on salivary gland tumors.
- Tooth development failure and metabolism of extracellular matrix molecules
- Intraepithelial stroma: its existence and function for tissue nutrition and migration of inflammatory cells
- Pathogenesis of odontogenic tumors and cysts
- Clinical and molecular pathologic study on recurrent superficail carcinomas of the oral mucosa
- Oral cytology: its clinical significance and accuracy




Manabu YAMAZAKIAssociate professorOral pathology
Yoshimasa SUMITAGraduate studentOral pathology
Yuki TAKAHASHITechnitianOral pathology
Satoshi MARUYAMALecturerOral pathology
Tatsuya ABÉResidentOral pathology





Izumi, K., Ono, Y., Saku, T / Cheilitis granulomatosa / Hashimoto, K / Electron Microscopic Atlas of Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 22 / 23 /

Izumi, K., Saku, T / Lichen planus / Hashimoto, K / Electron Microscopic Atlas of Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 24 / 25 /

Saku, T / Sjogren's syndrome / Hashimoto, K / Electron Microscopic Atlas of Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 54 / 55 /

Izumi, K., Saku, T / Odontogenic myxoma / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 64 / 65 /

Izumi, K., Saku, T / Cherubism / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 92 / 93 /

Saku, T / Granular cell tumor / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 100 / 101 /

Hamamoto, N., Ono, Y., Saku, T / Squamous cell carcinoma / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 112 / 113 /

Izumi, K., Saku, T / Leiomyosarcoma / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 124 / 125 /

Saku, T / Burkitt's lymphoma / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 136 / 137 /

Izumi, K., Saku, T / Basal cell adenoma / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 150 / 151 /

Cheng J., Saku, T / Adenoid cystic carcinoma / Hashimoto, K / Electron Microscopic Atlasof Oral Disease / / Nagasue Shoten / Kyoto / 1998 / 154 / 155 /

Saku T, Cheng J, Komiyama K, Kohgo T, Tanaka Y, Izumo T, Hasegawa H, Ishida T, Ogawa I, Takata T, Semba I, Yamamoto H / Guidelines for Histopatholgoical Diagnosis of Borderline Malignancies of the Oral Mucosa / / / / Yamazaki Publishing Inc., Ltd / Niigata / 2005 / 1 / 27 /

Saku, T / Oral CIS Catalog / / Oral Carcinoma in-situ(JSOP) Catalog histopathological variations / / Sunashobo Publishing.co.Ltd / Tokyo / 2007 / 1 / 91 /

The Working Committee for New Histopathological Criteria for Borderline Malignancies of the Oral Mucosa, the Japanese Society of Oral Pathology (JSOP) (including Saku T, Cheng J) / Oral CIS Catalog / / histopathological variations (electronic edition) / / / Tokyo / 2013 / 1 / 96 /

Saku T / The Department of Medical Research (Upper Myanmar) the 15th Anniversary Magazine. / / International Colloaboration towards Prevention of Oral Cancer: My Twenty Years Experience up to the Myanmar Project / / / Myanmar / 2015 / 209 / 214 /



Tomizawa, M., Yonomochi, H., Kohno, m., Noda, Tadashi / Unilateral delayed eruption ofmaxillary first molars: four case reports / American Academy of Pediatric Dentistry / 51 / 53 / 56 / 1998 /

Hao, N., Yonomochi, H., Saku, T / Melanotic Neuroectodermal tumor of infancy arising in themandible / Oral Medicine & Patholgy / 37 / 119 / 119 / 1998 /

Oda, Y., Cheng, J.,Saku, T / Chondrosarcoma of the temporomandibular joint / Oral Medicine & Patholgy / 29 / 118 / 118 / 1998 /

Munakata, R., Yonemochi, H., Taira, S., Saku, T / Malignant fibrous histiocytoma of the mandible / Oral Medicine & Patholgy / 20 / 117 / 117 / 1998 /

Munakata, R., Cheng, J., Nakajima, T., Saku, T / Spindle cell carcinoma of the gingiva / Journal of Oral Pathology & Medicine / 3 / 180 / 184 / 1998 /

Izumi, K., Nakajima, T., Maeda, T., Cheng, J., Saku, T / Adenosquamous carcinoma of tongue / Oral Surgery Oral Medicine Oral Pathology / 3 / 178 / 184 / 1998 /

Okuda, k., Murata, M., Sugimoto, M., Saito, Y., Kabasawa, Y., Yoshie, H., Saku, T., Hara, K / TGF-β1 influences early gingival wound healing in rats: an immunohistochemical evaluationof stromal remodelling by extracellular matrix molecules and PCNA. /

Journal of Oral Pathology & Medicine / 3 / 463 / 469 / 1998 /

Yonemochi, H., Noda, T., Saku, T / Pericoronal hamartomatous lesions in the opercula ofteeth delayed in eruption: an immunohistochemical study of extracellar matrix / Journal of Oral Pathology & Medicine / 27 / 441 / 452 / 1998 /

Iri_. T., Cheng, J., Kimura, S., Munakata, R., Taira, S., Saku, T / Intracellular transportof basement memmbrane-type heparan sulphate proteoglycan in adenoid cystic carcinoma cells of salivary gland origin: an immunoelectron microscopic study / Virchows Archiv / 65 / 41 / 48 / 1998 / Online Journal

Naito, Y., Kimura, S., Yoshizawa, M., Ohtake, K., Nakajima, T., Saku, T / Effects of theanticancer drug cocktail UFT on metastatic potentials of squamous cell carcinoma (O-1N) ina hamster model / Oral Oncology / 34 / 326 / 331 / 1998 / Online Journal

Ono, Y., Nakajima, T., Saku, T / Vascular invasion of O-1N, hamster squamous cell carcinoma with high potential of lymph node metastasis: Ultrastrucutural comparison between lymphatics and blood vessels / Pathology International / 27 / 254 / 264 / 1998 /

Saku, T / Basement membrane proteoglycan / Glycoword, Glycoforum / 433 / / / 1998 / Online Journal

Fujimori, Y., Cheng, J., Yonemochi, H., Kaji, M., Takagi, R., Saku, T / Desmoplastic ameloblastoma of the maxilla: Its difficulty in differential diagnosis by biopsy / Oral Medicine & Pathology / 34 / 104 / 104 / 1999 /

Hao, N., Cheng, J., Imai, N., Takagi, R., Saku, T / Mucous retention cysts in cervical lymph nodes metastasized by mucoepidermoid carcinoma of the buccal mucosa / Oral Medicine & Pathology / 40 / 103 / 104 / 1999 /

Tomizawa, M., Kohno, M., Noda, T., Suzuki, M / Three cases of palatal polyps in infants / International Journal of Paediatric Dentistry / 28 / 213 / 217 / 1999 / Online Journal

Tanaka, Y., Ishikura, Y., Tomizawa, M., Noda, T., Naito, Y / Radicular cyst associated with upper primary canine resulting in malposition of the permanent successor / Pediatric Dental Journal / 9 / 111 / 115 / 1999 /

Hayashi, T., Ito, J., Kato, T., Hinoki, A., Taira, S., Saku, T / Intracortical hemangioma of the mandible / Dentomaxillofacial Radiology / 20 / 127 / 129 / 1999 /

Iaumi, K., Nakajima, T., Maeda, T., Irie, T., Murata, M., Saku, T / Polypoid mass of the gingiva / Oral Surgery Oral Medicine Oral Pathology Endodontics and Dental Radiology / 60 / 117 / 121 / 1999 /

Ida-Yonemochi, H., Noda, T., Ono, Y., Saku, T / Xanthomatous lesion of the gingiva: A possible cause of delayed tooth eruption / Oral Medicine & Pathology / 4 / 79 / 84 / 1999 / Online Journal

Takata, T., Kudo, Y., Zhao, M., Ogawa, I., Miyaushi, M., Sato, S., Cheng, J., Nikai H / Reduced expression of p27Kip1 protein in relation to salivary adenoid cystic carcioma metastasis / Cancer / 66 / 929 / 935 / 1999 /

Yonemochi, H., Noda, T., Shimokawa, H., Saku, T / Immunohistochemical localization of extracellular matrix molecules in complex odontoma. / Dentistry in Japan / 35 / 13 / 19 / 1999 /

Toyoshima, K., Kimura, S., Cheng, J., Oda, Y., Mori, K. J., Saku, T / High-molecular-weight fibronectin synthesized by adenoid cystic carcinoma cells of salivary gland origin / Japanese Journal of Cancer Research / 90 / 308 / 319 / 1999 /

Hoshina, Y., Hamamoto, Y., Suzuki, I., Nakajima, T., Ida-Yonemochi, H., Saku, T. / Melanotic neuroectodermal tumor of infancy in the mandible / Oral Surgery Oral Medicine Oral Pathology Endodontics and Dental Radiology / 89 / 594 / 599 / 2000 /

Kimura, S., Cheng, J., Ida, H., Hao, N., Fujimori, Y., Saku, T / Perlecan (heparan sulfate proteoglycan) gene expression reflected in the characteristic histological architecture of salivary adenoid cystic carcinoma / Virchows Archiv / 2 / 122 / 128 / 2000 / Online Journal

Fujimori, Y., Cheng, J., Suzuki, M., Takagi, R., Saku, T / Histologic evaluation of incisional biopsy samples of pleomorphic adenomas of the palate: a technical guideline for successful pathologic diagnosis / Oral Medicine & Pathology / 5 / 25 / 28 / 2000 /

Murata, M., Cheng, J., Horino, K., Hara, K., Shimokawa, H., Saku, T / Enamel proteins and extracellular matrix molecules are co-localized in the pseudocystic stromal space of adenomatoid odontogenic tumor / Journal of Oral Pathology & Medicine / 29 / 483 / 490 / 2000 / Online Journal

Niimi, K.,Yoshizawa, M.,Nakajima, T., Saku, T / Vascular invasion in squamous cell carcinomas of human oral mucosa / Oral Oncology / 37 / 357 / 364 / 2001 / Online Journal

Sabit,H.,Tsuneyama,K.,Shimonishi,T.,Harada,K.,Cheng,J.,Ida,H.,Saku,T.,Saito,K.,Nakayama,Y / Enhanced expression of basement-membrane-type heparan sulfate proteoglycan in tumor fibro-myxoid stroma of intrahepatic cholangiocarcinoma / Pathology International / 51 / 240 / 256 / 2001 /

Ida-Yonemochi, H., Ikarashi, T., Nagata, M., Hoshina, H., Takagi, R. and Saku, T / The basement membrane-type heparan sulfate proteoglycan (perlecan) in ameloblastomas: its intercelluar localization in stellate reticulum-like foci and biosynthesis by tumor cells in culture. / / 441 / 165 / 173 / 2002 /

Ida-Yonemochi, H., Noda, T., Shimokawa, H. and Saku, T / Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas / Journal of Oral Pathology & Medicine / 31 / 361 / 373 / 2002 /

Ida-Yonemochi, H. and Saku, T / No developmental failure of cultured tooth germs from osteopetrotic (op/op) mice / Journal of Oral Pathology & Medicine / 31 / 374 / 378 / 2002 /

Oda, Y., Cheng, J., Nakajima, T. and Saku, T / Expression of adhesion molecules in the vascular invasionn process of O-1N, hamster squamous cell carcinoma with high potential of lymph node metastasis / Oral Medicine & Pathology / 7 / 9 / 18 / 2002 /

Frierson, HF., El-Naggar, AK., Welsh, JB., Sapinoso, LM., Su, AI., Cheng, J., Saku, T., Moskaluk, CA. and Hampton, GM / Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma / American Journal of Pathology / 161 / 1315 / 1323 / 2002 /

Ohtaké, S., Cheng, J., Ida, H., Suzuki, M., Ohshiro, K., Zhang, W. and Saku, T. / Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry / Journal of Oral Pathology & Medicine / 31 / 590 / 597 / 2002 /

Jen kai Yu., Cheng, J., Maruyama, S., Hayashi, T., Suzuki, I., Shingaki, S. and Saku, T / Mucoepidermoid carcinoma in children: Report of a case and review of literature / Oral Medicine & Pathology, / 7 / 27 / 31 / 2002 /

Hayashi, T., Ito, J., Katura, K., Honma, S., Shingaki, S., Ikarashi, T. and Saku, T / Malignant melamoma of mandibular gingiva; the usefulness of fat-saturated MRI / Dentomaxillofacial Radiology / 31 / 151 / 153 / 2002 / Online Journal

Maruyama, S., Hao, N., Cheng, J., Horino, K., Ohnishi, M., Fukushi, M., Fujii, M. and Saku, T / Castleman' s disease of the buccal mucosa: Report of a case and review of the literature of head and neck cases / Oral Surgery Oral Medcine Oral Pathology Oral Radiolgy and Endodontic / 93 / 305 / 310 / 2002 /

Maruyama, S., Cheng, J., Inoue, T., Takagi, R. and Saku, T / Sebaceous lymphadenoma of the lip: Report of a case of minor salivary gland origin / Journal of Oral Pathology & Medicine / 31 / 242 / 243 / 2002 / Online Journal

Noguchi, M., Tomizawa, M., Suzuki, M. and Noda, T / Impacted supernumerary tooth developed under palatal polyp / International Journal of Paediatric Dentistry / 12 / 281 / 285 / 2002 /

Saku, T., Cheng, J., Jen, K. Y., Tokunaga, M., Liu, A. R., Wu, L., Lu, Y., Zhou, Z., Li, Y., Li, R., Ouyang, J, Yang, L., Yu, S., Lou, T., Wang, S., Lin, D., Rao, H., Lin, H., Sderk, P., Chen, Z., Cai, C., Kim, H., hong, S. / Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asian area: a clinicopathologic study of 160 cases. / Archives of Pathology / 47 / 45 / 51 / 2003 /

Ito, M., Izumi, N, Cheng, J., Sakai, H., Shingaki, S., Nakajima, T., Oda, K. and Saku, T. / Jaw bone remodeling at the invasion front of gingival squamous cell carcinoma / Journal of Oral Pathology & Medicine / 32 / 10 / 17 / 2003 /

Jen, K. Y., Cheng, J., Li, J., Wu, L., Li, Y., Yu, S., Lin H., Chen, Z., Gurtsevitch, V. and Saku T. / Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas. / International Journal of Cancer / 105 / 654 / 660 / 2003 / Online Journal

Ida-Yonemochi H, Ishibashi O, Sakai H, Saku T / Recruitment of osteoclasts in the mandible of osteopetrotic (op/op) mice. / European Journal of Oral Sciences / 112 / 148 / 155 / 2004 /

Maruya S, Kurotaki H, Wada R, Saku T, Shinkawa H, Yagihashi S / Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma / Modern Pathology / 17 / 637 / 645 / 2004 /

Wu LY, Cheng J, Lu Y, Zhou ZY, Saku T / Epstein-Barr virus infection in benign lymphoepithelial lesions with malignant transformation of salivary gl / Chinese Journal of Stomatology / 39 / 291 / 293 / 2004 /

Wu LY, Cheng J, Lu Y, Zhou ZY, Saku T / Epstein-Barr virus infection in lymphoepithelial carcinoma of salivary glands in Sichuan Chinese / Sichuan Medical Journal / 35 / 506 / 507 / 2004 /

Jen KY, Cheng J, Takagi R, Tanaka R, Hayashi T, Saku T / Central hemangioma of the maxilla: report of a case with an exophytic growth / Oral Oncology Extra / 40 / 88 / 90 / 2004 / Online Journal

Swelam W, Ida-Yonemochi H, Maruyama S, Ikarashi T, Fukuda J, Takagi R, Hayashi T, Saku T / Solitary fibrous tumor of the lower lip involving minor salivary gland components: report of a case and review of the literature of salivary gland cases / Oral Oncology Extra / 40 / 107 / 112 / 2004 / Online Journal

Metwaly H, Cheng J, Suzuki M, Takata Y, Saitoh C, Hayashi T, Saku T / Benign lymphoepithelial lesion of minor salivary gland: report of a case involving the palatal mucosa / Oral Oncology Extra / 40 / 113 / 116 / 2004 / Online Journal

Angiogenesis in mucous retention cyst: a human in vivo-like model of endothelial cell differentiation in mucous substrate / Journal of Oral Pathology & Medicine / 34 / 30 / 38 / 2005 / http://www.blackwell-synergy.com/doi/full/10.1111/j.1600-0714.2004.00282.x /

Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity / Journal of Oral Pathology & Medicine / 34 / 59 / 61 / 2005 / http://www.blackwell-synergy.com/doi/full/10.1111/j.1600-0714.2004.00230.x /

Syafriadi M, Cheng J, Jen KY, Ida-Yonemochi H, Suzuki M, Saku T / Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells / Journal of Oral Pathology & Medicine / 34 / 140 / 149 / 2005 / Online Journal

Jen KY, Higuchi M, Cheng J, Li J, Wu LY, Li YF, Lin HL, Chen Z, Gurtsevitch V, Fujii M, Saku T / Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas / Virus Genes / 30 / 223 / 235 / 2005 / Online Journal

Ida-Yonemochi H, Ohshiro K, Swelam W, Metwaly H, Saku T / Perlcan, a basement membrane-type heparan sulfate proteoglycan, in the enamel organ: its intraepithelial localization in the stellate reticulum / Journal of Histochemistry & Cytochemistry / 53 / 763 / 772 / 2005 / Online Journal

Swelam W, Ida-Yonemochi H, Maruyama S, Ohshiro K, Cheng J, Saku T: / Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. / Virchows Archiv / 446 / 653 / 662 / 2005 / Online Journal

Yamada A, Fukumoto E, Kamasaki Y, Ida-Yonemochi H, Saku T, Fujiwara T, Fukumoto S / GD3 synthase gene found expressed in denta epitheliu and shown to regulate cell proliferation. / Archives of Oral Biology / 50 / 393 / 399 / 2005 / Online Journal

Metwaly H, Cheng J, Maruya S, Ohshiro K, Suzuki I, Hoshina Y, Saku T / Establishmen and characterization of new cell lines derived from melanoti neuroectodermal tumor of infancy arising in the mandible / Pathology International, / 55 / 331 / 342 / 2005 / Online Journal

Fukumoto S, Miner JH, Ida H, Fukumoto E, Yuasa K, Miyazaki H, Hoffman MP, Yamada Y / Laminin α5 is required for dental epithelium growth and polarity and the development of tooth bud and shape / Jouna of Biological Chemistry / 281 / 5008 / 5016 / 2005 / Online Journal

Utunomiya H, Tilakaratne WM, Ohshiro K, Maruyama S, Suzuki M, Ida-Yonemochi H, Cheng J, Saku T / Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization / Journal of Oral Pathology & Medicine / 34 / 498 / 507 / 2005 / Online Journal

Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S / Oral submucous fibrosis: review on aetiology and pathogenesis / Oral Oncology / 42 / 561 / 568 / 2006 / Online Journal

Ida-Yonemochi H, Saku T / Perlcan, a heparan sulfate proteoglycan, is a major constituent of the intraepithelial stroma functioning in tooth morphogenesis / Journal of Oral Biosciences / 48 / 233 / 243 / 2006 / Online Journal

Kundu S, Cheng J,Maruyama S, Suzuki M, Kawashima H, Saku T / Lymphatic involvement in the histopathogenesis of mucous retention cyst / Pathology Research and practice / 203 / 89 / 97 / 2007 / Online Journal

Sawair F, Al-Mutwake A, Al-Eryani K, Al-Surhy A, Maruyama S, Cheng J, Al-Sharabi A, Saku T / High relative frequency of oral squamous cell carcinoma in Yemen: Qat and tobacco shewing as its aetiological background / International Journal of Environmental Health Resarch / 17 / 185 / 195 / 2007 / Online Journal

Hara H, Oyama T, Saku T / Fine needle aspiration cytology of basal cell adenoma of the salivary gland. / Act Cytologica / 51 / 685 / 691 / 2007 /

Sawair F, Cheng J, Hao N, Maruyama S, Hoshina H, Takagi R, Koyama J, Hayashi T, Saku T / Periosteal osteosarcoma of the jaw bones: a clinicopathological review. / Oral Medicine & Pathology / 12 / 3 / 10 / 2007 / Online Journal

Maruyama S, Cheng J, Zhou XJ, Chen WT, Zhang ZY, Li J, Saku T / FGF7/KGF Enhances proliferation but suppresses invasion of adenoid cystic carcinoma cells. / Oral Oncology / 12 / 243 / 250 / 2008 /

Tsuneki M, Cheng J, Maruyama S, Ida-Yonemochi H, Nakajima M, Saku T / Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor. / Oral Medicine & Pathology / 12 / 89 / 96 / 2008 / Online Journal

Kurokawa A, Nagata M, Kitamura N, Noman AA, Ohnishi M, Ohyama T, Kobayashi T, Shingaki S, Takagi R / Diagnostic value of integrin α3, β4, and β5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma. / Cancer / 112 / 1272 / 1281 / 2008 / Online Journal

Tsuneki M, Cheng J, Maruyama S, Ida-Yonemochi H, Nakajima M, Saku T / Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor / Journal of Oral pathology & Medicine / 37 / 287 / 293 / 2008 / Online Journal

Saito M, Nishiyama S, Maruyama S, Oda Y, Saku T, Hayashi T / Adenoid cystic carcinoma of sublingual glamd involving the submandibular duct. / Dentomaxillofacial Radiology / 37 / 421 / 424 / 2008 / Online Journal

Kubota T, Itagaki M, Morozumi T, Maruyama S, Nakasone N, Shimizu T, Saku T, Yoshie H / A case report of multiple-drug-induced gingival overgrowth with TIMP-3 over-expression. / Oral Medicine & Pathology / 12 / 141 / 148 / 2008 / Online Journal

Sawair FA, Cheng J, Yamazaki M, Al-Eryani K, Khraisat A, Ono Y, kito K, Ono K, Takagi R, Saku T / Epithelioid hemangioendothelioma of the tongue: a report of solitary and multiple lesions in two young children / Oral Medicine & Pathology / 13 / 15 / 20 / 2008 / Online Journal

Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Mikami T, Alvarado C, Ahsan S, Maruyama S, Cheng J, Saku T / Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers. / Journal of Oral pathology & Medicine / 38 / 348 / 355 / 2009 / Online Journal

Wu L, Cheng J, Maruyama S, Yamazaki M, Tsuneki M, Lu Y, He Z, Zheng Y, Zhou Z, Saku T / Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases. / . Human Pathology / 40 / 683 / 692 / 2009 / Online Journal

Maruyama S, Cheng J, Yamazaki M, Liu A, Saku T / Keratinocyte growth fasctor colocalized with perlecan at the site of capsular invasion and vascular involvement in salivary pleomorphic adenomas, / Journal of Oral pathology & Medicine / 38 / 377 / 385 / 2009 / Online Journal

Swelam WM, Cheng J, Ida-Yonemochi H, Maruyama S, Saku T / Oral solitary fibrous tumor : a cytogenetic analysis of tumor cells in sulture with literature review. / Cancer, Genetics and Cyrogenetics / 194 / 75 / 81 / 2009 /

Munakara R, Sawair FA, Cheng J, Saku T / Gingival metastasis of ovarian carcinoma: report of a case and review of the literature / Oral & Maxillofacial Surgery / 38 / 1123 / 1126 / 2009 /

Tilakaratne WM, Jayasooriya PR, Tennakoon MPB, Saku T / Epithelial salivary tumors in Sri Lanka: A retrospective study of 713 cases / Oral Surgely Oral MedicineOral Pathology Oral Radiology Endod / 108 / 90 / 98 / 2009 /

Al-Eryani K, Sawair FA, Maruyama S, Watanabe M, Kawahara R, Yokobayashi T, Kobayashi T, Kundu S, Syafriadi M, Cheng J, Saku T / Nerve sheath myxoma of tha tongue: report of a case and revirw of the literature / Oral Medicine & Pathology / 13 / 105 / 110 / 2009 /

Abe M, Maruyama S, Yamazaki M, Kobayashi T, Al-Eryani K, Ahsan M, Tsuneki M, Syafriadi M, Swelam W, Yamazaki M, Mikami T, Alvarado C, Ahsan S, Maruyama S, Saku T, Cheng J / The absence of significant mutation events of the p53 gene in the only two salivary gland tumors possessiong radiation-related development risks, mucoepidermoid carcinoma and Warthin tumor / Oral Medicine & Pathology / 13 / 151 / 158 / 2009 /

Sawair FA, Ryalat S, Shayyab M, Saku T / The unstimulated salivary flow rate in a Jordanian healthy adult population. / Journal of Clinical Medicine Resarch / 1 / 219 / 225 / 2009 /

Sawair FA, Shayyab MH, Al-Rabab'ad MA, Saku T / Prevalence and clinical characteristics of tori and jaw exostoses in a teaching hospital in Jordan / Saudi Medical Journal / 30 / 1557 / 1562 / 2009 /

Maruyama S, Cheng J, Yamazaki M, Zhou XJ, Zhang ZY, He RG, Saku T / Metastasis-associated genes in salivary adenoid cystic carcinoma and oral squamous cell carcinoma: a differential DNA chip analysis between metastic and nonmetastatic cell systems / Cancer, Genetics and Cyrogenetics / 194 / 75 / 81 / 2009 /

Metwaly H, Maruyama S, Cheng J, Hoshina H, Takagi R, Hayashi T, Saku T: / Central neurilemoma of the mandible: report of a case and review of the literature. / Oral Medicine & Pathology, / 15 / 29 / 33 / 2010 /

Ida-Yonemochi H, Tanebe Y, Ono Y, Murata M, Saku T: / Focal osteoporotic bone marrow defects associated with a cystic change of the maxilla: a possible histopathogenetic background of simple bone cyst / Oral Medicine & Pathology, / 15 / 35 / 38 / 2010 /

Kobayashi T, Maruyama S, Cheng J, Ida-Yonemochi H, Yagi M,Takagi R, Saku T: / Histopathological varieties of oral carcinoma in-situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia. / Pathology International, / 60 / 154 / 164 / 2010 /

Tsuneki M, Yamazaki M, Cheng J, Maruyama S, Kobayashi T, Saku T: / Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology. / Histopathology / 57 / 806 / 813 / 2010 /

Sami MM, Saito M, Muramatsu S, Mikami T, Kikuchi H, Saku T: / A computer-aided distinction method of borderline grades of oral cancer. / IEICE (The Institute of Electoronics, Information and Communication Engineers) Transactions Fundamentals / E93 / 1544 / 1552 / 2010 /

Ida-Yonemochi H, Nakajima M, Saku T: / Heparanase, heparin sulfate and perlecan distribution along with the vascular penetration during stellate reticulum retraction in the mouse enamel organ / Archives of Oral Biology / 55 / 778 / 787 / 2010 /

Oo HN, Myint YY, Maung CN, Oo PS, Cheng J, Maruyama S, Yamazaki M, Yagi M, Sawair FA, Saku T: / Oral cancer in Myanmar: a preliminary survey based on hospital-based cancer registries. / ournal of Oral Pathology and Medicine, / 40 / 20 / 26 / 2011 / Online Journal

Ida-Yonemochi H, Ahsan MS, Saku T: / Differential expression profiles between α-dystoroglycan and integrin β1 in ameloblastoma: two possible perlecan signalling pathways for cellular growth and differentiation. / Histopathology / 58 / 234 / 245 / 2011 / Online Journal

Katsura K, Maruyama S, Suzuki M, Saku T, Takagi R, Hayashi T: / A case of desmoplastic ameloblastoma arising in the maxillary alveolus: the origin and time-course changes in the early stage of tumour development observed on dental radiographs. / Dentomaxillofacial Radiology / 40 / 126 / 129 / 2011 / Online Journal

Ahsan MS, Maruyama S, Cheng J, Al-Eryani K, Yamazaki M, Hasegawa M, Tsuneki M, Saku T: / Acetic acid treatment for wrinkle-free oral mucosal epithelia in paraffin section preparation. / Microscopy Reseach and techniqu / 74 / 475 / 482 / 2011 / Online Journal

Ahsan MS, Yamazaki M, Maruyama S, Kobayashi T, Ida-Yonemochi H, Cheng J, Hasegawa M, Adeola HA, Saku T: / Differential expression of perlecan receptors, α-dystroglycan and integrin β1, before and after invasion of oral squamous cell carcinoma. / Journal of Oral Pathology & Medicine / 40 / 552 / 559 / 2011 / Online Journal

Sho T, Tadasuke T, Sato T, Kondo T, Cheng J, Saku T, Asaka M, Hatakeyama S: / TRIM29 negatively regulates p53 via inhibition of Tip60 / Biochemica et Biophysica Acta / 1813 / 1245 / 1253 / 2011 / Online Journal

Funayama A, Cheng J, Maruyama S, Yamazaki M, Kobayashi T, Syafriadi M, Kundu S, Shingaki S, Saito C, Saku T: / Enhanced expressions of podoplanin in oral carcinoma in-situ and squamous cell carcinoma. / Pathobiology / 78 / 171 / 180 / 2011 / Online Journal

Hasegawa M, Cheng J, Maruyama S, Yamazaki M, Iida A, Takagi R, Tanaka R, Hayashi T, Saito C, Saku T: / Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: Report of a case and its etiological background. / International Journal of Oral & Maxillofacial Surgery / 40 / 647 / 650 / 2011 / Online Journal

Kuyama K, Sun Y, Fukui K, Maruyama S, Ochiai E, Fukumoto M, Ikeda N, Kondoh T, Iwadate K, Takagi R, Saku T, Yamamoto H: / Tumor mimicking actinomycosis of the upper lip: report of two cases. / Oral Medicine & Pathology / 15 / 95 / 99 / 2011 / Online Journal

Alvarado CG, Maruyama S, Cheng J, Ida-Yonemochi H, Kobayashi T, Yamazaki M, Takagi R, Saku T: / Nuclear translocation of β-catenin synchronized with loss of E-cadherin in oral epithelial dysplasia with a characteristic two-phase appearence. / Histopathology / 59 / 283 / 291 / 2011 / Online Journal

Hasegawa M, Cheng J, Maruyama S, Yamazaki M, Saku T: / Sialadenitis as a possible risk factor for salivary gland cancer. / International Journal of Oral Maxillofacial Surgery / 40 / 1449 / 1450 / 2011 / Online Journal

Abu Eid R, Sawair F, Landini G, Saku T: / Age and the architecture of oral mucosa. / AGE, Journal of American Aging Association. / 34 / 651 / 658 / 2011 / Online Journal

Ida-Yonemochi H, Satokata I, Ohshima H, Sato T, Yokoyama M, Yamada Y, Saku T: / Morphogenetic roles of perlecan in the tooth enamel organ: an analysis of overexpression using transgenic mice. / Matrix Biology / 30 / 379 / 388 / 2011 / Online Journal

Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura KI, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, Arai T, Takubo K: / Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. / Journal of Oral Pathology and Medicine / 41 / 372 / 378 / 2012 / Online Journal

Ida-Yonemochi H, Maruyama S, Kobayashi T, Yamazaki M, Cheng J, Saku T: / Loss of keratin 13 in oral carcinoma in-situ: a comparative study of protein and gene expression levels using paraffin sections. / Modern Pathology / 25 / 784 / 794 / 2012 / Online Journal

Tsuneki M, Maruyama S, Yamazaki M, Cheng J, Saku T: / Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures. / Pathology Research and Practice / 208 / 140 / 148 / 2012 / Online Journal

Saito M, Kobyashi T, Takagi R, Saku T: / Clinicopathological distinction of two categories of oral squamous cell carcinoma of the tongue: de novo vs. sequential types. / Oral Medicine & Pathology / 16 / 81 / 88 / 2012 / Online Journal

Funayama A, Maruyama S, Yamazaki M, Al-Eryani K, Shingaki S, Saito C, Cheng J, Saku T: / Intraepithelially entrapped blood vessels in oral carcinoma in-situ. / Virchows Archiv / 460 / 473 / 480 / 2012 / Online Journal

Tsuneki M, Maruyama S, Yamazaki M, Abé T, Adeola HA, Cheng J, Nishiyama H, Hasyashi T, Kobayashi T, Takagi R, Funayama A, Saito C, Saku T: / Inflammatory histopathogenesis of nasopalatine duct cyst: a clinicopathological study of 41 cases. / Oral Diseases / 19 / 415 / 424 / 2012 / Online Journal

Kobayashi T, Maruyama S, Cheng J, Takagi R, Saito C, Saku T: / Keratin-10-positive orthokeratotic dysplasia: a new leukoplakia-type precancerous entity of the oral mucosa. / Histopathology / 61 / 910 / 920 / 2012 / Online Journal

Metwaly H, Maruyama S, Yamazaki M, Tsuneki M, Abé T, Jen KY, Cheng J, Saku T: / Parenchymal-stromal swithing for extracellular matrix production on invasion of oral squamous cell carcinoma. / Human Pathology / 43 / 1973 / 1981 / 2012 / Online Journal

Tsuneki M, Maruyama S, Yamazaki M, Essa A, Abé T, Babkair HA, Ahsan MS, Cheng J, Saku T: / Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation. / Virchows Archiv / 462 / 297 / 305 / 2012 / Online Journal

Arashiyama T, Kodama Y, Kobayashi T, Hoshina H, Takagi R, Hayashi T, Cheng J, Saku T: / Ghost cell ocontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. / Oral Surgery Oral Medicine Oral Pathology Oral Radiology / 114 / e35 / e40 / 2012 / Online Journal

Metwaly H, Cheng J, Maruyama S, Yamazaki M, Essa A, Abé T, Babkair H, Hoshina H, Takagi R, Hayashi T, Saku T: / Central neurofibroma of the mandible: Report of a case and review of the literature. / Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology / 43 / 1973 / 1981 / 2012 / Online Journal

Tomita T, Kubota T, Nakasone N, Morozumi T, Abe D, Maruyama S, Shimizu T, Horimizu M, Saku T, Yoshie H: / Gene and protein localisation of tumour necrosis factor (TNF)-α converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth. / Archives of Oral Biology / 58 / 1014 / 1020 / 2013 / Online Journal

Al-Eryani K, Cheng J, Abé T, Yamazaki M, Maruyama S, Tsuneki M, Essa A, Babkair H, Saku T: / Hemophagocytosis-mediated keratinization in oral carcinoma in-situ and squamous cell carcinoma: a possible histopathogenesis of keratin pearls / Journal of Cellular Physiology / 228 / 1977 / 1988 / 2013 / Online Journal

Tsuneki M, Maruyama S, Yamazaki M, Xu B, Essa A, Abé T, Babkair H, Cheng J, Yamamoto T, Saku T: / Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells. / Biochemical and Biophysical Research Communication / 434 / 124 / 130 / 2013 / Online Journal

Ida-Yonemochi H, Harada H, Ohshima H, Saku T: / Reciprocal expressions between α-dystroglycan and integrin β1, perlecan receptors, in the murine enamel organ development. / Gene Expression Patterns / 13 / 293 / 304 / 2013 / Online Journal

Tsuneki M, Yamazaki M, Maruyama S, Cheng J, Saku T: / Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma. / Laboratory Investigation / 462 / 297 / 305 / 2013 / Online Journal

Kuyama K, Fukui K, Ochiai E, Maruyama S, Iwadate K, Saku T, Yamamoto H: / Identification of the Actinomycete 16S rRNA gene by polymerase chain reaction in oral inflammatory lesions. / Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology / 116 / 485 / 791 / 2013 / Online Journal

Abé T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, Shingaki S, Kobayashi T, Hayashi T, Cheng J, Saku T: / Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry / Human Pathology / 45 / 110 / 118 / 2013 / Online Journal

Sohda M, Misumi Y, Tashiro K, Yamazaki M, Saku T, Oda K / Identification of a soluble isoform of human IL-17RA generated by alternative splicing / Cytokine, / 64 / 642 / 645 / 2013 / Online Journal

Metwaly H, Abdel-Moniem ME, Saku T / Vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in oral lichen planus: An immunohistochemical study for the correlation between vascular and lymphocytic reactions / Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology / 26 / 390 / 396 / 2014 / Online Journal

The Working Committee for New Histopathological Criteria for Borderline Malignancies of the Oral Mucosa, the Japanese Society of Oral Pathology (JSOP) (including Saku T, Cheng J). / Carcinoma in-situ of the oral mucosa: its pathological diagnostic concept based on the recognition of histological varieties proposed in the JSOP Oral CIS Catalog / Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology / 26 / 397 / 406 / 2014 / Online Journal

Maruyama S, Itagaki M, Ida-Yonemochi H, Kubota T, Yamazaki M, Abé T, Yoshie H, Cheng J, Saku T / Perlecan-enriched intercellular space of junctional epithelium provides primary infrastructure for leucocyte migration through squamous epithelial cells / Histochemistry and Cell Biology / 142 / 297 / 305 / 2014 / Online Journal

Maruyama S, Shimazu Y, Kudo T, Sato K, Yamazaki M, Abé T, Babkair H, Cheng J, Aoba T, Saku T / Three-dimensional visualization of perlecan-rich neoplastic stroma induced concurrently with the invasion of oral squamous cell carcinoma / Journal of Oral Pathology and Medicine / 43 / 627 / 636 / 2014 / Online Journal

Essa AAM, Yamazaki M, Maruyama S, Abé T, Babkair H, Cheng J, Saku T / Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages / Journal of Oral Pathology and Medicine / 43 / 778 / 784 / 2014 / Online Journal

Kubota T, Maruyama S, Abe D, Tomita T, Morozumi T, Nakasone N, Saku T, Yoshie H / Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues / Archives of Oral Biology / 59 / 586 / 594 / 2014 / Online Journal

Miyota S, Kobayashi T, Abé T, Miyajima H, Nagata M, Hoshina H, Kobayashi T, Takagi R, Saku T: / Intraoperative assessment of surgical margins of oral squamous cell carcinoma using frozen sections: a practical clinicopathological management for recurrences. / Biomed Research International / 26 / 390 / 396 / 2014 / Online Journal

Yamazaki M, Maruyama S, Abé T, Essa A, Babkair H, Cheng J, Saku T / MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells. / Laboratory Investigation, / 94 / 1260 / 1272 / 2014 / Online Journal

Abé T, Maruyama S, Babkair H, Yamazaki M, Cheng J, Saku T / Simultaneous immunolocalization of desmoglein 3 and IgG4 in oral pemphigus vulgaris: IgG4 predominant autoantibodies in its pathogenesis. / Journal of Oral Pathology and Medicine, / 44 / 850 / 856 / 2015 / Online Journal

Yamazaki M, Maruyama S, Abé T, Babkair H, Fujita H, Takagi R, Koyama J, Hayashi T, Cheng J, Saku T / Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature. / Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, / 111 / e12 / e18 / 2014 / Online Journal

Koyama T, Kobayashi T, Maruyama S, Abé T, Kodama Y, Hoshina H, Takagi R, Hayashi T, Saku T / Radiation-induced undifferentiated high-grade pleomorphic sarcoma (malignant fibrous histiocytoma) of the mandible: report of a case arising in the background of long-standing osteomyelitis with a review of the literature. / Pathology - Research and Practice / 210 / 1123 / 1129 / 2014 / Online Journal

Al-Eryani K, Cheng J, Abé T, Maruyama S, Yamazaki M, Babkair H, Essa A, Saku T / Protease-activated receptor-2 modulates proliferation and invasion of oral squamous cell carcinoma cells. / Human Pathology / 46 / 991 / 999 / 2015 / Online Journal

Maruyama S, Yamazaki M, Abé T, Babkair H, Cheng J, Saku T / Paradental cyst is an inclusion cyst of the junctional/sulcular epithelium of the gingiva: histopathological and immunohistochemical confirmation for its pathogenesis / Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, / 120 / 227 / 237 / 2015 / Online Journal

Dhanuthai K, Rojanawatsirivej S, Somkotra T, Shin H, Hong S, Darling M, Khalili M, Thosaporn W, Rattana-arpha P, Saku T / Geriatric oral lesions: A multicentric study. / Geriatrics & Gerontology International / 16 / 237 / 243 / 2016 / Online Journal

Mikami T, Maruyama S, Abé T, Kobayashi T, Yamazaki M, Funayama A, Shingaki S, Kobayashi T, Cheng J, Saku T / Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in-situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration. / Virchows Archiv / 466 / 559 / 569 / 2016 / Online Journal

Tsuneki M, Madri JA, Saku T / Cell-extracellular interactions in oral tumorigenesis: the roles of podoplanin and CD44 and modulation of the Hippo pathway. / Journal of Oral Biosciences / 57 / 45 / 53 / 2016 / Online Journal

Hasegawa M, Cheng J, Maruyama S, Yamazaki M, Abé T, Babkair H, Saito C, Saku T / Differential immunohistochemical expression profiles of perlecan-binding growth factors in epithelial dysplasia, carcinoma in-situ, and squamous cell carcinoma of the oral mucosa / Pathology - Research and Practice / 212 / 426 / 436 / 2016 / Online Journal

Essa AAM, Yamazaki M, SMaruyama S, Abé T, Babkair H, Raghib AM, Megahed EMED, Cheng J, Saku T / Tumor-associated macrophages are recruited and differentiated in the neoplastic stroma of oral squamous cell carcinoma. / Pathology / 48 / 219 / 227 / 2016 / Online Journal

Babkair H, Yamazaki M, Uddin MS, Maruyama S, Abé T, Essa A, Sumita Y, Ahsan MS, Swelam W, Cheng J, Saku T / Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma. / Human Pathology / 57 / 51 / 60 / 2016 / Online Journal

Shingaki M, Nikkuni Y, Katsura K, Ikeda N, Maruyama S, Takagi R, Hasashi T / Clinical significance of intraoral strain elastography for diagnosing early stage tongue carcinoma: a preliminary study. / Oral Radiology / / / / / Online Journal

Hara Y, Ikeda N, Takagi R, Horino K, Iida A, Nishiyama H, Hayashi T, Cheng J, Saku T / Basaloid squamous cell carcinoma of the uvula: report of a case and review of the literature. / Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology / 28 / 234 / 238 / 2016 / Online Journal

Hara H, Misawa T, Ishii E, Nakagawa M, Koshiishi S, Amemiya K, Oyama T, Tomonaga K, Cheng J, Tanaka A, Saku T / Differential diagnosis of well-differentiated squamous cell carcinoma from non-neoplastic oral mucosal lesions: new cytopathologic evaluation method dependent on keratinization-related parameters but not nuclear atypism. / Diagnostic Cytopathology / 45 / 406 / 417 / 2017 / Online Journal

Abé T, Maruyama S, Yamazaki M, Xu B, Babkair H, Sumita Y, Cheng J, Yamamoto T, Saku T / Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion. / Experimental and Molecullar Pathology / 102 / 327 / 336 / 2017 / Online Journal

Nezu A, Kubota T, Maruyama S, Nagata M, Nohno K, Morizumi T, Yoshie H / Expression of neprilysin in periodontitis-affected gingival tissues /  Archives of Oral Biology / 79 / 35 / 41 / 2017 / Online Journal






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